Human Gene ARHGAP22 (ENST00000435790.6) from GENCODE V44
Description: Homo sapiens Rho GTPase activating protein 22 (ARHGAP22), transcript variant 10, mRNA. (from RefSeq NM_001347738) RefSeq Summary (NM_001256025): This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. Gencode Transcript: ENST00000435790.6 Gencode Gene: ENSG00000128805.15 Transcript (Including UTRs) Position: hg38 chr10:48,446,242-48,652,616 Size: 206,375 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr10:48,446,391-48,652,285 Size: 205,895 Coding Exon Count: 10
ID:RHG22_HUMAN DESCRIPTION: RecName: Full=Rho GTPase-activating protein 22; AltName: Full=Rho-type GTPase-activating protein 22; FUNCTION: Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). SUBUNIT: Interacts with VEZF1 (By similarity). INTERACTION: O00555:CACNA1A; NbExp=2; IntAct=EBI-3866859, EBI-766279; SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Mainly cytoplasmic. Some fraction is nuclear (By similarity). SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 Rho-GAP domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z5H3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
