Human Gene CASP7 (ENST00000369321.6) from GENCODE V44
Description: Homo sapiens caspase 7 (CASP7), transcript variant f, mRNA. (from RefSeq NM_001267057) RefSeq Summary (NM_001267057): This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]. Gencode Transcript: ENST00000369321.6 Gencode Gene: ENSG00000165806.21 Transcript (Including UTRs) Position: hg38 chr10:113,679,669-113,730,907 Size: 51,239 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr10:113,679,755-113,729,540 Size: 49,786 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
