Human Gene PTPRB (ENST00000550857.5) from GENCODE V44
Description: Homo sapiens protein tyrosine phosphatase receptor type B (PTPRB), transcript variant 3, mRNA. (from RefSeq NM_001206971) RefSeq Summary (NM_001206971): The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]. Gencode Transcript: ENST00000550857.5 Gencode Gene: ENSG00000127329.16 Transcript (Including UTRs) Position: hg38 chr12:70,521,403-70,609,843 Size: 88,441 Total Exon Count: 31 Strand: - Coding Region Position: hg38 chr12:70,521,489-70,609,814 Size: 88,326 Coding Exon Count: 31
ID:PTPRB_HUMAN DESCRIPTION: RecName: Full=Receptor-type tyrosine-protein phosphatase beta; Short=Protein-tyrosine phosphatase beta; Short=R-PTP-beta; EC=3.1.3.48; AltName: Full=Vascular endothelial protein tyrosine phosphatase; Short=VE-PTP; Flags: Precursor; FUNCTION: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity). CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. SUBUNIT: Monomer. Interacts with TEK. Interacts via fibronectin type-III 17 domain with CDH5 (By similarity). INTERACTION: P04626:ERBB2; NbExp=2; IntAct=EBI-1265766, EBI-641062; P10912:GHR; NbExp=3; IntAct=EBI-1265766, EBI-286316; Q02763:TEK; NbExp=3; IntAct=EBI-1265766, EBI-2257090; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). INDUCTION: Up-regulated by hypoxia. SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. SIMILARITY: Contains 17 fibronectin type-III domains. SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P23467
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
