Human Gene SYT16 (ENST00000555409.1) from GENCODE V44
  Description: May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent. (from UniProt Q17RD7)
Gencode Transcript: ENST00000555409.1
Gencode Gene: ENSG00000139973.18
Transcript (Including UTRs)
   Position: hg38 chr14:61,995,834-62,101,713 Size: 105,880 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr14:61,996,020-62,080,903 Size: 84,884 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:61,995,834-62,101,713)mRNA (may differ from genome)Protein (383 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
HPRDLynxMalacardsMGIneXtProtPubMed
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: SYT16_HUMAN
DESCRIPTION: RecName: Full=Synaptotagmin-16; AltName: Full=Chr14Syt; AltName: Full=Synaptotagmin 14-like protein; AltName: Full=Synaptotagmin XIV-related protein;
FUNCTION: May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.
SUBUNIT: Homodimer. Can also form heterodimers (By similarity).
TISSUE SPECIFICITY: Expressed in brain.
SIMILARITY: Belongs to the synaptotagmin family.
SIMILARITY: Contains 2 C2 domains.
SEQUENCE CAUTION: Sequence=CAE85114.1; Type=Erroneous termination; Positions=72; Note=Translated as Gln;

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.01 RPKM in Testis
Total median expression: 6.79 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -34.80186-0.187 Picture PostScript Text
3' UTR -514.101881-0.273 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000008 - C2_Ca-dep
IPR008973 - C2_Ca/lipid-bd_dom_CaLB
IPR018029 - C2_membr_targeting

Pfam Domains:
PF00168 - C2 domain

ModBase Predicted Comparative 3D Structure on Q17RD7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0019905 syntaxin binding
GO:0030276 clathrin binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0005544 calcium-dependent phospholipid binding

Biological Process:
GO:0006887 exocytosis
GO:0006906 vesicle fusion
GO:0017158 regulation of calcium ion-dependent exocytosis
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter

Cellular Component:
GO:0005886 plasma membrane


-  Descriptions from all associated GenBank mRNAs
  AK302919 - Homo sapiens cDNA FLJ60997 complete cds, highly similar to Homo sapiens synaptotagmin XVI (SYT16), mRNA.
AJ617628 - Homo sapiens mRNA for synaptotagmin 16 (SYT16 gene), splice variant 1.
BC117363 - Homo sapiens synaptotagmin XVI, mRNA (cDNA clone MGC:150972 IMAGE:40125914), complete cds.
BC143598 - Homo sapiens synaptotagmin XVI, mRNA (cDNA clone MGC:177127 IMAGE:9052110), complete cds.
HQ258344 - Synthetic construct Homo sapiens clone IMAGE:100072653 synaptotagmin XVI (SYT16) gene, encodes complete protein.
KJ899723 - Synthetic construct Homo sapiens clone ccsbBroadEn_09117 SYT16 gene, encodes complete protein.
AB102949 - Homo sapiens syt14r mRNA for synaptotagmin XIV-related protein Strep14, complete cds.
JD530880 - Sequence 511904 from Patent EP1572962.
BC040924 - Homo sapiens synaptotagmin XVI, mRNA (cDNA clone IMAGE:5767986), complete cds.
JD535956 - Sequence 516980 from Patent EP1572962.
JD094185 - Sequence 75209 from Patent EP1572962.
JD530748 - Sequence 511772 from Patent EP1572962.
JD332663 - Sequence 313687 from Patent EP1572962.
KJ903361 - Synthetic construct Homo sapiens clone ccsbBroadEn_12755 SYT16 gene, encodes complete protein.
AJ303367 - Homo sapiens partial mRNA for synaptotagmin 16 (SYT16 gene).
JD539479 - Sequence 520503 from Patent EP1572962.
JD171608 - Sequence 152632 from Patent EP1572962.
JD196776 - Sequence 177800 from Patent EP1572962.
JD323621 - Sequence 304645 from Patent EP1572962.
JD437842 - Sequence 418866 from Patent EP1572962.
JD219382 - Sequence 200406 from Patent EP1572962.
JD201351 - Sequence 182375 from Patent EP1572962.
JD207025 - Sequence 188049 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AJ617628, B7ZL60, C9J8I3, Q17RD7, Q707N2, Q7Z441, Q8IUU0, Q9BQR8, STREP14, SYT14L, SYT14R, SYT16_HUMAN, uc010tse.1, uc010tse.2
UCSC ID: ENST00000555409.1
RefSeq Accession: NM_001367656
Protein: Q17RD7 (aka SYT16_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.