Human Gene NUDT14 (ENST00000392568.7) from GENCODE V44
Description: Homo sapiens nudix hydrolase 14 (NUDT14), transcript variant 1, mRNA. (from RefSeq NM_177533) RefSeq Summary (NM_177533): The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]. Gencode Transcript: ENST00000392568.7 Gencode Gene: ENSG00000183828.15 Transcript (Including UTRs) Position: hg38 chr14:105,172,939-105,181,312 Size: 8,374 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr14:105,173,021-105,181,209 Size: 8,189 Coding Exon Count: 5
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95848
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein O95848 (Reactome details) participates in the following event(s):
R-HSA-6810464 NUDT14 hydrolyses UDP-Glc to G1P and UMP R-HSA-480985 Synthesis of dolichyl-phosphate-glucose R-HSA-446219 Synthesis of substrates in N-glycan biosythesis R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
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