Human Gene SLC47A1 (ENST00000436810.6) from GENCODE V44
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt E7EX57)
RefSeq Summary (NM_018242): This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000436810.6
Gencode Gene: ENSG00000142494.13
Transcript (Including UTRs)
   Position: hg38 chr17:19,533,828-19,577,611 Size: 43,784 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg38 chr17:19,533,940-19,577,336 Size: 43,397 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:19,533,828-19,577,611)mRNA (may differ from genome)Protein (443 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
LynxMGIPubMedUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: E7EX57_HUMAN
DESCRIPTION: SubName: Full=Multidrug and toxin extrusion protein 1;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 59.33 RPKM in Adrenal Gland
Total median expression: 227.34 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -47.00112-0.420 Picture PostScript Text
3' UTR -77.90275-0.283 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002528 - MATE

Pfam Domains:
PF01554 - MatE

ModBase Predicted Comparative 3D Structure on E7EX57
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0015238 drug transmembrane transporter activity
GO:0015297 antiporter activity

Biological Process:
GO:0006855 drug transmembrane transport
GO:0055085 transmembrane transport

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK310270 - Homo sapiens cDNA, FLJ17312.
AK301854 - Homo sapiens cDNA FLJ51767 complete cds.
AK222625 - Homo sapiens mRNA for hypothetical protein FLJ10847 variant, clone: CBL03007.
AK302620 - Homo sapiens cDNA FLJ58865 complete cds.
AK001709 - Homo sapiens cDNA FLJ10847 fis, clone NT2RP4001379.
BC022390 - Homo sapiens cDNA clone IMAGE:4610447, with apparent retained intron.
JD409394 - Sequence 390418 from Patent EP1572962.
AK225360 - Homo sapiens mRNA for hypothetical protein LOC55244 variant, clone: HEP13329.
BC010661 - Homo sapiens solute carrier family 47, member 1, mRNA (cDNA clone MGC:8805 IMAGE:3874616), complete cds.
BC058882 - Homo sapiens solute carrier family 47, member 1, mRNA (cDNA clone MGC:64822 IMAGE:5188651), complete cds.
BC050592 - Homo sapiens solute carrier family 47, member 1, mRNA (cDNA clone IMAGE:5186314), partial cds.
JD409384 - Sequence 390408 from Patent EP1572962.
CU691318 - Synthetic construct Homo sapiens gateway clone IMAGE:100021670 5' read SLC47A1 mRNA.
KJ902795 - Synthetic construct Homo sapiens clone ccsbBroadEn_12189 SLC47A1 gene, encodes complete protein.
KJ894166 - Synthetic construct Homo sapiens clone ccsbBroadEn_03560 SLC47A1 gene, encodes complete protein.
KR709712 - Synthetic construct Homo sapiens clone CCSBHm_00005316 SLC47A1 (SLC47A1) mRNA, encodes complete protein.
KR709713 - Synthetic construct Homo sapiens clone CCSBHm_00005317 SLC47A1 (SLC47A1) mRNA, encodes complete protein.
KR709714 - Synthetic construct Homo sapiens clone CCSBHm_00005318 SLC47A1 (SLC47A1) mRNA, encodes complete protein.
KR709715 - Synthetic construct Homo sapiens clone CCSBHm_00005319 SLC47A1 (SLC47A1) mRNA, encodes complete protein.
AK293196 - Homo sapiens cDNA FLJ55387 complete cds.
AK304647 - Homo sapiens cDNA FLJ51200 complete cds.
AK298254 - Homo sapiens cDNA FLJ51020 complete cds.
JD288199 - Sequence 269223 from Patent EP1572962.
JD046584 - Sequence 27608 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK301854, E7EX57, E7EX57_HUMAN, ENST00000436810.1, ENST00000436810.2, ENST00000436810.3, ENST00000436810.4, ENST00000436810.5, uc010vyz.1, uc010vyz.2
UCSC ID: ENST00000436810.6
RefSeq Accession: NM_018242
Protein: E7EX57

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.