Human Gene EZH1 (ENST00000590078.5) from GENCODE V44
Description: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. (from UniProt Q92800) RefSeq Summary (NM_001991): EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009]. Gencode Transcript: ENST00000590078.5 Gencode Gene: ENSG00000108799.13 Transcript (Including UTRs) Position: hg38 chr17:42,702,385-42,745,037 Size: 42,653 Total Exon Count: 20 Strand: - Coding Region Position: hg38 chr17:42,702,532-42,727,670 Size: 25,139 Coding Exon Count: 18
ID:EZH1_HUMAN DESCRIPTION: RecName: Full=Histone-lysine N-methyltransferase EZH1; EC=2.1.1.43; AltName: Full=ENX-2; AltName: Full=Enhancer of zeste homolog 1; FUNCTION: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SUBUNIT: Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. The PRC2/EED-EZH1 is less abundant than the PRC2/EED-EZH2 complex, has weak methyltransferase activity and compacts chromatin in the absence of the methyltransferase cofactor S-adenosyl-L-methionine (SAM). SUBCELLULAR LOCATION: Nucleus. Note=Colocalizes with trimethylated 'Lys-27' of histone H3. SIMILARITY: Belongs to the histone-lysine methyltransferase family. EZ subfamily. SIMILARITY: Contains 1 CXC domain. SIMILARITY: Contains 1 SET domain. SEQUENCE CAUTION: Sequence=BAA20842.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF11616 - WD repeat binding protein EZH2 PF00856 - SET domain
ModBase Predicted Comparative 3D Structure on Q92800
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
