Human Gene ST8SIA5 (ENST00000538168.5) from GENCODE V44
Description: Homo sapiens ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 (ST8SIA5), transcript variant 1, mRNA. (from RefSeq NM_001307986) RefSeq Summary (NM_001307986): The protein encoded by this gene is a type II membrane protein that may be present in the Golgi apparatus. The encoded protein, which is a member of glycosyltransferase family 29, may be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, and GT3 from GD1a, GT1b, GM1b, and GD3, respectively. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000538168.5 Gencode Gene: ENSG00000101638.14 Transcript (Including UTRs) Position: hg38 chr18:46,667,821-46,756,809 Size: 88,989 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr18:46,680,042-46,756,508 Size: 76,467 Coding Exon Count: 8
ID:SIA8E_HUMAN DESCRIPTION: RecName: Full=Alpha-2,8-sialyltransferase 8E; EC=2.4.99.-; AltName: Full=Sialyltransferase 8E; Short=SIAT8-E; AltName: Full=Sialytransferase St8Sia V; Short=ST8SiaV; FUNCTION: May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively. PATHWAY: Protein modification; protein glycosylation. SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein (Potential). TISSUE SPECIFICITY: Expressed in fetal and adult brain, adult heart and skeletal muscle. SIMILARITY: Belongs to the glycosyltransferase 29 family. WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST8SIA5"; WEB RESOURCE: Name=Functional Glycomics Gateway - GTase; Note=ST8Sia V; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_640";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00777 - Glycosyltransferase family 29 (sialyltransferase)
ModBase Predicted Comparative 3D Structure on O15466
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0005975 carbohydrate metabolic process GO:0006486 protein glycosylation GO:0006688 glycosphingolipid biosynthetic process GO:0097503 sialylation
AK090499 - Homo sapiens cDNA FLJ33180 fis, clone ADRGL2003638. AX746482 - Sequence 7 from Patent EP1308459. AK054755 - Homo sapiens cDNA FLJ30193 fis, clone BRACE2001340. JD372299 - Sequence 353323 from Patent EP1572962. JD276473 - Sequence 257497 from Patent EP1572962. JD467283 - Sequence 448307 from Patent EP1572962. JD480727 - Sequence 461751 from Patent EP1572962. JD374197 - Sequence 355221 from Patent EP1572962. JD230706 - Sequence 211730 from Patent EP1572962. JD339012 - Sequence 320036 from Patent EP1572962. JD114406 - Sequence 95430 from Patent EP1572962. JD355369 - Sequence 336393 from Patent EP1572962. AK095045 - Homo sapiens cDNA FLJ37726 fis, clone BRHIP2019819. JD103727 - Sequence 84751 from Patent EP1572962. JD282850 - Sequence 263874 from Patent EP1572962. JD126741 - Sequence 107765 from Patent EP1572962. JD276298 - Sequence 257322 from Patent EP1572962. JD518845 - Sequence 499869 from Patent EP1572962. JD352906 - Sequence 333930 from Patent EP1572962. JD318067 - Sequence 299091 from Patent EP1572962. JD072879 - Sequence 53903 from Patent EP1572962. JD070637 - Sequence 51661 from Patent EP1572962. JD535474 - Sequence 516498 from Patent EP1572962. JD355680 - Sequence 336704 from Patent EP1572962. JD503013 - Sequence 484037 from Patent EP1572962. JD267235 - Sequence 248259 from Patent EP1572962. JD152964 - Sequence 133988 from Patent EP1572962. JD133276 - Sequence 114300 from Patent EP1572962. JD416680 - Sequence 397704 from Patent EP1572962. JD321219 - Sequence 302243 from Patent EP1572962. JD281406 - Sequence 262430 from Patent EP1572962. JD491995 - Sequence 473019 from Patent EP1572962. JD160759 - Sequence 141783 from Patent EP1572962. JD562375 - Sequence 543399 from Patent EP1572962. JD353676 - Sequence 334700 from Patent EP1572962. JD342928 - Sequence 323952 from Patent EP1572962. JD528964 - Sequence 509988 from Patent EP1572962. JD171551 - Sequence 152575 from Patent EP1572962. JD360036 - Sequence 341060 from Patent EP1572962. JD049444 - Sequence 30468 from Patent EP1572962. JD064897 - Sequence 45921 from Patent EP1572962. JD471173 - Sequence 452197 from Patent EP1572962. JD518556 - Sequence 499580 from Patent EP1572962. JD502409 - Sequence 483433 from Patent EP1572962. JD085256 - Sequence 66280 from Patent EP1572962. JD057100 - Sequence 38124 from Patent EP1572962. JD526470 - Sequence 507494 from Patent EP1572962. JD213472 - Sequence 194496 from Patent EP1572962. JD341579 - Sequence 322603 from Patent EP1572962. AK094273 - Homo sapiens cDNA FLJ36954 fis, clone BRACE2005800, highly similar to Alpha-2,8-sialyltransferase 8E (EC 2.4.99.-). AK056270 - Homo sapiens cDNA FLJ31708 fis, clone NT2RI2006271, highly similar to Alpha-2,8-sialyltransferase 8E (EC 2.4.99.-). AK130126 - Homo sapiens cDNA FLJ26616 fis, clone MPB06888, highly similar to Homo sapiens sialyltransferase 8E (alpha-2, 8-polysialyltransferase) (SIAT8E). JD521864 - Sequence 502888 from Patent EP1572962. U91641 - Human alpha2,8-sialyltransferase mRNA, complete cds. BC108910 - Homo sapiens ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5, mRNA (cDNA clone MGC:119670 IMAGE:40011279), complete cds. BC108911 - Homo sapiens ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5, mRNA (cDNA clone MGC:119671 IMAGE:40011281), complete cds. JD317866 - Sequence 298890 from Patent EP1572962. JD438200 - Sequence 419224 from Patent EP1572962. JD453026 - Sequence 434050 from Patent EP1572962. AK293608 - Homo sapiens cDNA FLJ60231 complete cds, highly similar to Alpha-2,8-sialyltransferase 8E (EC 2.4.99.-). JD189069 - Sequence 170093 from Patent EP1572962. JD542445 - Sequence 523469 from Patent EP1572962. JD460417 - Sequence 441441 from Patent EP1572962. JD492585 - Sequence 473609 from Patent EP1572962. JD483155 - Sequence 464179 from Patent EP1572962. JD241469 - Sequence 222493 from Patent EP1572962. JD552028 - Sequence 533052 from Patent EP1572962. JD327120 - Sequence 308144 from Patent EP1572962. AK298881 - Homo sapiens cDNA FLJ52727 complete cds, highly similar to Alpha-2,8-sialyltransferase 8E (EC 2.4.99.-). JD525556 - Sequence 506580 from Patent EP1572962. JD467153 - Sequence 448177 from Patent EP1572962. JD405752 - Sequence 386776 from Patent EP1572962. JD482984 - Sequence 464008 from Patent EP1572962. JD408306 - Sequence 389330 from Patent EP1572962. KJ893706 - Synthetic construct Homo sapiens clone ccsbBroadEn_03100 ST8SIA5 gene, encodes complete protein. CR457037 - Homo sapiens full open reading frame cDNA clone RZPDo834C0218D for gene SIAT8E, sialyltransferase 8E (alpha-2, 8-polysialyltransferase); complete cds, incl. stopcodon. AK310764 - Homo sapiens cDNA, FLJ17806. JD461217 - Sequence 442241 from Patent EP1572962. JD393205 - Sequence 374229 from Patent EP1572962. JD044913 - Sequence 25937 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00604 - Glycosphingolipid biosynthesis - ganglio series hsa01100 - Metabolic pathways
Reactome (by CSHL, EBI, and GO)
Protein O15466 (Reactome details) participates in the following event(s):
R-HSA-4084978 ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues R-HSA-4085001 Sialic acid metabolism R-HSA-446219 Synthesis of substrates in N-glycan biosythesis R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins