Human Gene TJP3 (ENST00000587686.1) from GENCODE V44
Description: Interacts with occludin, claudins and ZO-1. Interacts with INADL (By similarity). Interacts with UBN1. Interacts with FASLG. (from UniProt O95049) RefSeq Summary (NM_001267561): The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012]. Gencode Transcript: ENST00000587686.1 Gencode Gene: ENSG00000105289.15 Transcript (Including UTRs) Position: hg38 chr19:3,728,376-3,750,813 Size: 22,438 Total Exon Count: 20 Strand: + Coding Region Position: hg38 chr19:3,728,376-3,750,684 Size: 22,309 Coding Exon Count: 20
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95049
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
