Human Gene GRAMD1A (ENST00000317991.10) from GENCODE V44
  Description: Homo sapiens GRAM domain containing 1A (GRAMD1A), transcript variant 1, mRNA. (from RefSeq NM_020895)
Gencode Transcript: ENST00000317991.10
Gencode Gene: ENSG00000089351.15
Transcript (Including UTRs)
   Position: hg38 chr19:35,000,323-35,026,469 Size: 26,147 Total Exon Count: 20 Strand: +
Coding Region
   Position: hg38 chr19:35,000,479-35,026,141 Size: 25,663 Coding Exon Count: 20 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:35,000,323-35,026,469)mRNA (may differ from genome)Protein (724 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDMGIneXtProtPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GRM1A_HUMAN
DESCRIPTION: RecName: Full=GRAM domain-containing protein 1A;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Contains 1 GRAM domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 71.24 RPKM in Whole Blood
Total median expression: 1082.23 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -89.40156-0.573 Picture PostScript Text
3' UTR -134.60328-0.410 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004182 - GRAM

Pfam Domains:
PF02893 - GRAM domain

ModBase Predicted Comparative 3D Structure on Q96CP6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF207616 - JP 2014500723-A/15119: Polycomb-Associated Non-Coding RNAs.
MA443193 - JP 2018138019-A/15119: Polycomb-Associated Non-Coding RNAs.
AK097215 - Homo sapiens cDNA FLJ39896 fis, clone SPLEN2016972.
AK074864 - Homo sapiens cDNA FLJ90383 fis, clone NT2RP2005163.
BC014077 - Homo sapiens GRAM domain containing 1A, mRNA (cDNA clone MGC:20455 IMAGE:4126671), complete cds.
JD399639 - Sequence 380663 from Patent EP1572962.
AK074914 - Homo sapiens cDNA FLJ90433 fis, clone NT2RP3000721.
AB384616 - Synthetic construct DNA, clone: pF1KA1533, Homo sapiens GRAMD1A gene for GRAM domain-containing protein 1A, complete cds, without stop codon, in Flexi system.
JD176830 - Sequence 157854 from Patent EP1572962.
JD037193 - Sequence 18217 from Patent EP1572962.
LF367460 - JP 2014500723-A/174963: Polycomb-Associated Non-Coding RNAs.
MA603037 - JP 2018138019-A/174963: Polycomb-Associated Non-Coding RNAs.
JD532142 - Sequence 513166 from Patent EP1572962.
JD189948 - Sequence 170972 from Patent EP1572962.
JD112207 - Sequence 93231 from Patent EP1572962.
JD170522 - Sequence 151546 from Patent EP1572962.
LF367459 - JP 2014500723-A/174962: Polycomb-Associated Non-Coding RNAs.
MA603036 - JP 2018138019-A/174962: Polycomb-Associated Non-Coding RNAs.
JD150266 - Sequence 131290 from Patent EP1572962.
JD230681 - Sequence 211705 from Patent EP1572962.
JD054609 - Sequence 35633 from Patent EP1572962.
AB040966 - Homo sapiens mRNA for KIAA1533 protein, partial cds.
CU680766 - Synthetic construct Homo sapiens gateway clone IMAGE:100018388 5' read GRAMD1A mRNA.
AK074827 - Homo sapiens cDNA FLJ90346 fis, clone NT2RP2002976.
LF367458 - JP 2014500723-A/174961: Polycomb-Associated Non-Coding RNAs.
MA603035 - JP 2018138019-A/174961: Polycomb-Associated Non-Coding RNAs.
LF367457 - JP 2014500723-A/174960: Polycomb-Associated Non-Coding RNAs.
MA603034 - JP 2018138019-A/174960: Polycomb-Associated Non-Coding RNAs.
LF367456 - JP 2014500723-A/174959: Polycomb-Associated Non-Coding RNAs.
MA603033 - JP 2018138019-A/174959: Polycomb-Associated Non-Coding RNAs.
LF367454 - JP 2014500723-A/174957: Polycomb-Associated Non-Coding RNAs.
MA603031 - JP 2018138019-A/174957: Polycomb-Associated Non-Coding RNAs.
LF367453 - JP 2014500723-A/174956: Polycomb-Associated Non-Coding RNAs.
MA603030 - JP 2018138019-A/174956: Polycomb-Associated Non-Coding RNAs.
AK026064 - Homo sapiens cDNA: FLJ22411 fis, clone HRC08456.
BC041618 - Homo sapiens GRAM domain containing 1A, mRNA (cDNA clone IMAGE:5921205).
LF367452 - JP 2014500723-A/174955: Polycomb-Associated Non-Coding RNAs.
MA603029 - JP 2018138019-A/174955: Polycomb-Associated Non-Coding RNAs.
LF367451 - JP 2014500723-A/174954: Polycomb-Associated Non-Coding RNAs.
MA603028 - JP 2018138019-A/174954: Polycomb-Associated Non-Coding RNAs.
LF367450 - JP 2014500723-A/174953: Polycomb-Associated Non-Coding RNAs.
MA603027 - JP 2018138019-A/174953: Polycomb-Associated Non-Coding RNAs.
AK093555 - Homo sapiens cDNA FLJ36236 fis, clone THYMU2001357.
JD100353 - Sequence 81377 from Patent EP1572962.
JD355036 - Sequence 336060 from Patent EP1572962.
JD189845 - Sequence 170869 from Patent EP1572962.
JD135233 - Sequence 116257 from Patent EP1572962.
JD534661 - Sequence 515685 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NKY7, ENST00000317991.1, ENST00000317991.2, ENST00000317991.3, ENST00000317991.4, ENST00000317991.5, ENST00000317991.6, ENST00000317991.7, ENST00000317991.8, ENST00000317991.9, GRM1A_HUMAN, KIAA1533, NM_020895, Q8NC77, Q96CP6, Q9P1Z5, uc010xse.1, uc010xse.2, uc010xse.3
UCSC ID: ENST00000317991.10
RefSeq Accession: NM_020895
Protein: Q96CP6 (aka GRM1A_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.