Human Gene TATDN2 (ENST00000287652.8) from GENCODE V44
  Description: Putative deoxyribonuclease (By similarity). (from UniProt Q93075)
Gencode Transcript: ENST00000287652.8
Gencode Gene: ENSG00000157014.11
Transcript (Including UTRs)
   Position: hg38 chr3:10,248,023-10,281,216 Size: 33,194 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg38 chr3:10,249,201-10,279,025 Size: 29,825 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:10,248,023-10,281,216)mRNA (may differ from genome)Protein (761 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
HPRDLynxMGIneXtProtPubMedReactome
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: TATD2_HUMAN
DESCRIPTION: RecName: Full=Putative deoxyribonuclease TATDN2; EC=3.1.21.-;
FUNCTION: Putative deoxyribonuclease (By similarity).
COFACTOR: Binds 2 divalent metal cations per subunit (By similarity).
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the TatD DNase family.
SEQUENCE CAUTION: Sequence=BAA13208.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.38 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 80.28 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -494.901051-0.471 Picture PostScript Text
3' UTR -694.202005-0.346 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018228 - DNase_TatD-rel_CS
IPR001130 - TatD_family

Pfam Domains:
PF01026 - TatD related DNase

ModBase Predicted Comparative 3D Structure on Q93075
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004518 nuclease activity
GO:0004536 deoxyribonuclease activity
GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters
GO:0046872 metal ion binding

Biological Process:
GO:0006308 DNA catabolic process
GO:0036498 IRE1-mediated unfolded protein response
GO:0090305 nucleic acid phosphodiester bond hydrolysis

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0016607 nuclear speck


-  Descriptions from all associated GenBank mRNAs
  D86972 - Homo sapiens mRNA for KIAA0218 gene.
AK289794 - Homo sapiens cDNA FLJ76748 complete cds, highly similar to Homo sapiens TatD DNase domain containing 2 (TATDN2), mRNA.
DQ571531 - Homo sapiens piRNA piR-31643, complete sequence.
JD508521 - Sequence 489545 from Patent EP1572962.
BC090935 - Homo sapiens TatD DNase domain containing 2, mRNA (cDNA clone MGC:104979 IMAGE:3064714), complete cds.
JD560332 - Sequence 541356 from Patent EP1572962.
BC101776 - Homo sapiens TatD DNase domain containing 2, mRNA (cDNA clone MGC:126825 IMAGE:8069282), complete cds.
BC101770 - Homo sapiens TatD DNase domain containing 2, mRNA (cDNA clone MGC:126819 IMAGE:8069276), complete cds.
JD061152 - Sequence 42176 from Patent EP1572962.
AB383807 - Synthetic construct DNA, clone: pF1KSDA0218, Homo sapiens TATDN2 gene for TatD DNase domain-containing deoxyribonuclease 2, complete cds, without stop codon, in Flexi system.
DQ588061 - Homo sapiens piRNA piR-55173, complete sequence.
EU789553 - Homo sapiens clone TATDN2-T1 TATDN2/GHRLOS fusion mRNA, complete sequence.
EU789554 - Homo sapiens clone TATDN2-T2 TATDN2/GHRLOS fusion mRNA, complete sequence.
DQ596381 - Homo sapiens piRNA piR-34447, complete sequence.
DQ575373 - Homo sapiens piRNA piR-43485, complete sequence.
DQ584136 - Homo sapiens piRNA piR-51248, complete sequence.
DQ573723 - Homo sapiens piRNA piR-41835, complete sequence.
DQ572137 - Homo sapiens piRNA piR-40249, complete sequence.
DQ575202 - Homo sapiens piRNA piR-43314, complete sequence.
DQ593741 - Homo sapiens piRNA piR-33853, complete sequence.
DQ571166 - Homo sapiens piRNA piR-31278, complete sequence.
DQ596273 - Homo sapiens piRNA piR-34339, complete sequence.
DQ570943 - Homo sapiens piRNA piR-31055, complete sequence.
DQ586656 - Homo sapiens piRNA piR-53768, complete sequence.
DQ586657 - Homo sapiens piRNA piR-53769, complete sequence.
DQ590453 - Homo sapiens piRNA piR-57565, complete sequence.
DQ575623 - Homo sapiens piRNA piR-43735, complete sequence.
DQ588764 - Homo sapiens piRNA piR-55876, complete sequence.
DQ571266 - Homo sapiens piRNA piR-31378, complete sequence.
DQ588207 - Homo sapiens piRNA piR-55319, complete sequence.
DQ574446 - Homo sapiens piRNA piR-42558, complete sequence.
AK311203 - Homo sapiens cDNA, FLJ18245.
DQ577121 - Homo sapiens piRNA piR-45233, complete sequence.
DQ585176 - Homo sapiens piRNA piR-52288, complete sequence.
DQ585387 - Homo sapiens piRNA piR-52499, complete sequence.
JD383124 - Sequence 364148 from Patent EP1572962.
JD466256 - Sequence 447280 from Patent EP1572962.
DQ571190 - Homo sapiens piRNA piR-31302, complete sequence.
DQ571191 - Homo sapiens piRNA piR-31303, complete sequence.
DQ571192 - Homo sapiens piRNA piR-31304, complete sequence.
JD361523 - Sequence 342547 from Patent EP1572962.
JD357644 - Sequence 338668 from Patent EP1572962.
JD514697 - Sequence 495721 from Patent EP1572962.
JD545104 - Sequence 526128 from Patent EP1572962.
JD220679 - Sequence 201703 from Patent EP1572962.
JD215385 - Sequence 196409 from Patent EP1572962.
EU789547 - Homo sapiens clone UIS520-CAGE ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
EU789548 - Homo sapiens clone UIS512-CAGE ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
EU789549 - Homo sapiens clone UIS508-CAGE ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
EU789550 - Homo sapiens clone UIS506-CAGE ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
EU789551 - Homo sapiens clone UIS502-CAGE ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
EU789552 - Homo sapiens clone UIS500-CAGE ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
JD237820 - Sequence 218844 from Patent EP1572962.
JD349032 - Sequence 330056 from Patent EP1572962.
JD482532 - Sequence 463556 from Patent EP1572962.
JD219319 - Sequence 200343 from Patent EP1572962.
JD043994 - Sequence 25018 from Patent EP1572962.
JD066575 - Sequence 47599 from Patent EP1572962.
DQ591352 - Homo sapiens piRNA piR-58464, complete sequence.
JD039910 - Sequence 20934 from Patent EP1572962.
JD375556 - Sequence 356580 from Patent EP1572962.
JD500907 - Sequence 481931 from Patent EP1572962.
JD473497 - Sequence 454521 from Patent EP1572962.
JD103497 - Sequence 84521 from Patent EP1572962.
JD330291 - Sequence 311315 from Patent EP1572962.
JD379518 - Sequence 360542 from Patent EP1572962.
JD449411 - Sequence 430435 from Patent EP1572962.
JD561710 - Sequence 542734 from Patent EP1572962.
JD128544 - Sequence 109568 from Patent EP1572962.
JD391385 - Sequence 372409 from Patent EP1572962.
JD276616 - Sequence 257640 from Patent EP1572962.
JD276617 - Sequence 257641 from Patent EP1572962.
JD100178 - Sequence 81202 from Patent EP1572962.
JD300637 - Sequence 281661 from Patent EP1572962.
JD220846 - Sequence 201870 from Patent EP1572962.
JD496134 - Sequence 477158 from Patent EP1572962.
JD331820 - Sequence 312844 from Patent EP1572962.
JD350535 - Sequence 331559 from Patent EP1572962.
JD555412 - Sequence 536436 from Patent EP1572962.
DQ589761 - Homo sapiens piRNA piR-56873, complete sequence.
JD492332 - Sequence 473356 from Patent EP1572962.
JD435308 - Sequence 416332 from Patent EP1572962.
JD226917 - Sequence 207941 from Patent EP1572962.
JD528618 - Sequence 509642 from Patent EP1572962.
JD418310 - Sequence 399334 from Patent EP1572962.
EU789528 - Homo sapiens clone 5RLM-RACE-I ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
EU789529 - Homo sapiens clone 5RLM-RACE-II ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
EU789530 - Homo sapiens clone 5RLM-RACE-III ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
EU789538 - Homo sapiens clone E-UIS927 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
EU789534 - Homo sapiens clone A-UIS935 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
EU789535 - Homo sapiens clone B-UIS933 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
EU789536 - Homo sapiens clone C-UIS930 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
EU789537 - Homo sapiens clone D-UIS928 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
EU789539 - Homo sapiens clone F-UIS925 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
EU789540 - Homo sapiens clone G-UIS324 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
EU789541 - Homo sapiens clone H-UIS334 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
EU789542 - Homo sapiens clone I-UIS520 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
EU789543 - Homo sapiens clone J-UIS526 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
EU789544 - Homo sapiens clone K-UIS529 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
EU789545 - Homo sapiens clone L-UIS502 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
EU789546 - Homo sapiens clone M-UIS510 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.
JD049810 - Sequence 30834 from Patent EP1572962.
JD093465 - Sequence 74489 from Patent EP1572962.
JD184060 - Sequence 165084 from Patent EP1572962.
JD154523 - Sequence 135547 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q93075 (Reactome details) participates in the following event(s):

R-HSA-381038 XBP1(S) activates chaperone genes
R-HSA-381070 IRE1alpha activates chaperones
R-HSA-381119 Unfolded Protein Response (UPR)
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: D86972, ENST00000287652.1, ENST00000287652.2, ENST00000287652.3, ENST00000287652.4, ENST00000287652.5, ENST00000287652.6, ENST00000287652.7, KIAA0218, Q3MIL9, Q5BKU0, Q93075, TATD2_HUMAN, uc011atr.1, uc011atr.2, uc011atr.3
UCSC ID: ENST00000287652.8
RefSeq Accession: NM_014760
Protein: Q93075 (aka TATD2_HUMAN or TAT2_HUMAN)
CCDS: CCDS33698.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.