Human Gene ZNF721 (ENST00000506646.5) from GENCODE V44
  Description: zinc finger protein 721 (from HGNC ZNF721)
Gencode Transcript: ENST00000506646.5
Gencode Gene: ENSG00000182903.16
Transcript (Including UTRs)
   Position: hg38 chr4:426,789-474,142 Size: 47,354 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr4:435,816-473,983 Size: 38,168 Coding Exon Count: 6 

Page IndexSequence and LinksPrimersCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:426,789-474,142)mRNA (may differ from genome)Protein (132 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
LynxMalacardsMGIPubMedUniProtKB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.57 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 238.28 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -48.20159-0.303 Picture PostScript Text
3' UTR -72.70377-0.193 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box

Pfam Domains:
PF01352 - KRAB box

ModBase Predicted Comparative 3D Structure on B4E159
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
      
      
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005622 intracellular


-  Descriptions from all associated GenBank mRNAs
  BC036795 - Homo sapiens, clone IMAGE:5590487, mRNA.
AK024359 - Homo sapiens cDNA FLJ14297 fis, clone PLACE1008941.
BC098116 - Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 11 (pseudogene), mRNA (cDNA clone IMAGE:40024290).
BC098259 - Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 11 (pseudogene), mRNA (cDNA clone IMAGE:40024295).
BC098291 - Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 11 (pseudogene), mRNA (cDNA clone IMAGE:40024296), containing frame-shift errors.
BC099730 - Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 11 (pseudogene), mRNA (cDNA clone IMAGE:40024298).
BC105084 - Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 11 (pseudogene), mRNA (cDNA clone IMAGE:8144087).
BC112069 - Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 11 (pseudogene), mRNA (cDNA clone IMAGE:8327537).
BC143677 - Homo sapiens cDNA clone IMAGE:9052191.
AK303674 - Homo sapiens cDNA FLJ57767 complete cds, moderately similar to Zinc finger protein 141.
AL834155 - Homo sapiens mRNA; cDNA DKFZp761O0611 (from clone DKFZp761O0611).
AK128499 - Homo sapiens cDNA FLJ46649 fis, clone TRACH3004424, moderately similar to Zinc finger protein 91.
BC060316 - Homo sapiens cDNA clone IMAGE:3882186, partial cds.
BC065035 - Homo sapiens cDNA clone IMAGE:6171511, partial cds.
JD435224 - Sequence 416248 from Patent EP1572962.
JD102297 - Sequence 83321 from Patent EP1572962.
JD392731 - Sequence 373755 from Patent EP1572962.
BC040413 - Homo sapiens, clone IMAGE:5186165, mRNA.
JD516749 - Sequence 497773 from Patent EP1572962.
JD288829 - Sequence 269853 from Patent EP1572962.
JD163772 - Sequence 144796 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK303674, B4E159, B4E159_HUMAN, ENST00000506646.1, ENST00000506646.2, ENST00000506646.3, ENST00000506646.4, uc011buv.1, uc011buv.2, uc011buv.3
UCSC ID: ENST00000506646.5
RefSeq Accession: NR_002451
Protein: B4E159

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.