Human Gene HAUS3 (ENST00000506763.5) from GENCODE V44
Description: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. (from UniProt Q68CZ6) RefSeq Summary (NM_001303143): This gene encodes a component of the HAUS augmin-like protein complex, which plays a key role in cytokinesis and mitosis. Disruption of the encoded protein causes mitotic defects resulting from fragmentation of centrosomes and microtubule destabilization. This gene shares its 5' exons with some transcripts from overlapping GeneID: 353497, which encodes a DNA polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]. Gencode Transcript: ENST00000506763.5 Gencode Gene: ENSG00000214367.10 Transcript (Including UTRs) Position: hg38 chr4:2,227,464-2,242,121 Size: 14,658 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr4:2,228,411-2,240,946 Size: 12,536 Coding Exon Count: 4
ID:HAUS3_HUMAN DESCRIPTION: RecName: Full=HAUS augmin-like complex subunit 3; FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. SUBUNIT: Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. SIMILARITY: Belongs to the HAUS3 family. SEQUENCE CAUTION: Sequence=AAB97010.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH03648.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH03648.1; Type=Frameshift; Positions=12; Sequence=AAH25356.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q68CZ6
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK303673 - Homo sapiens cDNA FLJ61029 complete cds, highly similar to DNA polymerase nu (EC 2.7.7.7). AK293948 - Homo sapiens cDNA FLJ52073 complete cds. CR749640 - Homo sapiens mRNA; cDNA DKFZp686I1868 (from clone DKFZp686I1868). BC025356 - Homo sapiens chromosome 4 open reading frame 15, mRNA (cDNA clone MGC:39444 IMAGE:4906369), complete cds. AF040964 - Homo sapiens unknown protein IT1 mRNA, partial cds. BC003648 - Homo sapiens chromosome 4 open reading frame 15, mRNA (cDNA clone MGC:4701 IMAGE:3534250), complete cds. KJ904867 - Synthetic construct Homo sapiens clone ccsbBroadEn_14261 HAUS3 gene, encodes complete protein. AK056134 - Homo sapiens cDNA FLJ31572 fis, clone NT2RI2001731, weakly similar to INTRACELLULAR PROTEIN TRANSPORT PROTEIN USO1. CU678556 - Synthetic construct Homo sapiens gateway clone IMAGE:100020281 5' read C4orf15 mRNA. JD325784 - Sequence 306808 from Patent EP1572962. JD431662 - Sequence 412686 from Patent EP1572962. JD393458 - Sequence 374482 from Patent EP1572962. JD439800 - Sequence 420824 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q68CZ6 (Reactome details) participates in the following event(s):
R-HSA-380272 Plk1-mediated phosphorylation of Nlp R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome R-HSA-380294 Loss of C-Nap-1 from centrosomes R-HSA-380311 Recruitment of Plk1 to centrosomes R-HSA-380455 Recruitment of CDK11p58 to the centrosomes R-HSA-380303 Dissociation of Phospho-Nlp from the centrosome R-HSA-5626220 C2CD3 binds the mother centriole R-HSA-380508 Translocation of NuMA to the centrosomes R-HSA-2574845 AJUBA binds centrosome-associated AURKA R-HSA-8853405 TPX2 binds AURKA at centrosomes R-HSA-3000319 BORA binds PLK1 and AURKA R-HSA-2574840 AJUBA facilitates AURKA autophosphorylation R-HSA-3000310 AURKA phosphorylates PLK1 R-HSA-5626223 C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole R-HSA-5626681 Recruitment of transition zone proteins R-HSA-5626227 CP110 and CEP97 dissociate from the centriole R-HSA-380316 Association of NuMA with microtubules R-HSA-8853419 TPX2 promotes AURKA autophosphorylation R-HSA-5626228 The distal appendage proteins recruit TTBK2 R-HSA-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body R-HSA-5626699 MARK4 binds ODF2 in the centriole R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-8854518 AURKA Activation by TPX2 R-HSA-380287 Centrosome maturation R-HSA-5617833 Cilium Assembly R-HSA-68877 Mitotic Prometaphase R-HSA-69275 G2/M Transition R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-68886 M Phase R-HSA-453274 Mitotic G2-G2/M phases R-HSA-69278 Cell Cycle (Mitotic) R-HSA-1640170 Cell Cycle
US Server
