Human Gene PCDHA7 (ENST00000356878.5) from GENCODE V44
Description: Homo sapiens protocadherin alpha 7 (PCDHA7), transcript variant 2, mRNA. (from RefSeq NM_031852) RefSeq Summary (NM_031852): This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000356878.5 Gencode Gene: ENSG00000204963.6 Transcript (Including UTRs) Position: hg38 chr5:140,834,248-140,837,169 Size: 2,922 Total Exon Count: 1 Strand: + Coding Region Position: hg38 chr5:140,834,384-140,836,753 Size: 2,370 Coding Exon Count: 1
ID:PCDA7_HUMAN DESCRIPTION: RecName: Full=Protocadherin alpha-7; Short=PCDH-alpha-7; Flags: Precursor; FUNCTION: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (By similarity). SIMILARITY: Contains 6 cadherin domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UN72
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
