Human Gene BTN3A3 (ENST00000361232.7) from GENCODE V44
Description: Homo sapiens butyrophilin subfamily 3 member A3 (BTN3A3), transcript variant 2, mRNA. (from RefSeq NM_197974) RefSeq Summary (NM_197974): The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A3) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]. Gencode Transcript: ENST00000361232.7 Gencode Gene: ENSG00000111801.16 Transcript (Including UTRs) Position: hg38 chr6:26,440,488-26,452,815 Size: 12,328 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr6:26,443,998-26,452,411 Size: 8,414 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00478
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0002250 adaptive immune response GO:0002376 immune system process GO:0002456 T cell mediated immunity