Human Gene MPIG6B (ENST00000375805.6) from GENCODE V44
Description: Homo sapiens megakaryocyte and platelet inhibitory receptor G6b (MPIG6B), transcript variant 3, mRNA. (from RefSeq NM_138273) RefSeq Summary (NM_138273): This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000375805.6 Gencode Gene: ENSG00000204420.10 Transcript (Including UTRs) Position: hg38 chr6:31,723,370-31,725,074 Size: 1,705 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr6:31,723,384-31,725,074 Size: 1,691 Coding Exon Count: 5
ID:G6B_HUMAN DESCRIPTION: RecName: Full=Protein G6b; Flags: Precursor; FUNCTION: Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. Appears to operate in a calcium-independent manner. Isoform B is a putative inhibitory receptor. Isoform A may be its activating counterpart. SUBUNIT: Interacts with PTPN6 and PTPN11. Binds to heparin. SUBCELLULAR LOCATION: Isoform E: Endoplasmic reticulum. Golgi apparatus. SUBCELLULAR LOCATION: Isoform D: Endoplasmic reticulum. Golgi apparatus. SUBCELLULAR LOCATION: Isoform B: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform A: Cell membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Expressed in a restricted set of hematopoietic cell lines including the erythroleukemia cell line K-562 and the T-cell leukemia cell lines MOLT-4 and Jurkat. Not detected in the monocyte-like cell line U-937, the B-cell-like cell line Raji, the fibroblast cell lines TK and HeLa, or the natural killer cell lines NKL, NK 62 and YT. Expressed in platelets. PTM: All isoforms are N-glycosylated. PTM: Isoform E is O-glycosylated.
ModBase Predicted Comparative 3D Structure on O95866
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC113719 - Homo sapiens chromosome 6 open reading frame 25, mRNA (cDNA clone MGC:142279 IMAGE:8322771), complete cds. BC113721 - Homo sapiens chromosome 6 open reading frame 25, mRNA (cDNA clone MGC:142281 IMAGE:8322773), complete cds. BC143850 - Homo sapiens chromosome 6 open reading frame 25, mRNA (cDNA clone MGC:177383 IMAGE:9052366), complete cds. AK092392 - Homo sapiens cDNA FLJ35073 fis, clone PLACE6000630. AX747518 - Sequence 1043 from Patent EP1308459. HQ258117 - Synthetic construct Homo sapiens clone IMAGE:100072426 chromosome 6 open reading frame 25 (C6orf25), transcript variant 7 (C6orf25) gene, encodes complete protein. KJ899646 - Synthetic construct Homo sapiens clone ccsbBroadEn_09040 C6orf25 gene, encodes complete protein. BC111842 - Synthetic construct Homo sapiens clone IMAGE:40080852, MGC:133406 C6orf25 protein (C6orf25) mRNA, encodes complete protein. AB464091 - Synthetic construct DNA, clone: pF1KB7202, Homo sapiens G6B gene for Protein G6b, without stop codon, in Flexi system. AJ292259 - Homo sapiens mRNA for G6b-A protein (G6B gene), isoform A. AJ292260 - Homo sapiens mRNA for G6b-B protein (G6B gene), isoform B. AJ292261 - Homo sapiens mRNA for G6b-C protein (G6B gene), isoform C. AJ292262 - Homo sapiens mRNA for G6b-D protein (G6B gene), isoform D. AJ292263 - Homo sapiens mRNA for G6b-E protein (G6B gene), isoform E. AJ292264 - Homo sapiens mRNA for G6b-F protein (G6B gene), isoform F. AJ292265 - Homo sapiens mRNA for G6b-G protein (G6B gene), isoform G. JD077087 - Sequence 58111 from Patent EP1572962. JD065116 - Sequence 46140 from Patent EP1572962. JD138606 - Sequence 119630 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O95866 (Reactome details) participates in the following event(s):