Human Gene TCP11 (ENST00000373974.8) from GENCODE V44
  Description: Homo sapiens t-complex 11 (TCP11), transcript variant 4, mRNA. (from RefSeq NM_001261818)
Gencode Transcript: ENST00000373974.8
Gencode Gene: ENSG00000124678.20
Transcript (Including UTRs)
   Position: hg38 chr6:35,118,135-35,141,371 Size: 23,237 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg38 chr6:35,118,269-35,141,229 Size: 22,961 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:35,118,135-35,141,371)mRNA (may differ from genome)Protein (470 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TCP11_HUMAN
DESCRIPTION: RecName: Full=T-complex protein 11 homolog;
FUNCTION: May play an important role in sperm function and fertility.
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
TISSUE SPECIFICITY: Expressed only in fertile adult testis.
SIMILARITY: Belongs to the TCP11 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 214.63 RPKM in Testis
Total median expression: 217.95 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -60.50142-0.426 Picture PostScript Text
3' UTR -45.00134-0.336 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008862 - Tcp11

Pfam Domains:
PF05794 - T-complex protein 11

ModBase Predicted Comparative 3D Structure on Q8WWU5
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0007275 multicellular organism development
GO:0007283 spermatogenesis
GO:0010737 protein kinase A signaling
GO:0030154 cell differentiation
GO:0043949 regulation of cAMP-mediated signaling
GO:1902490 regulation of sperm capacitation

Cellular Component:
GO:0001669 acrosomal vesicle
GO:0005929 cilium
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle
GO:0031514 motile cilium
GO:0036126 sperm flagellum
GO:0042995 cell projection
GO:0097225 sperm midpiece


-  Descriptions from all associated GenBank mRNAs
  AF260330 - Homo sapiens tcp11-like protein mRNA, partial cds.
AF269223 - Homo sapiens TCP11 (TCP11) mRNA, complete cds.
AY069943 - Homo sapiens TCP11b protein mRNA, complete cds.
AF536532 - Homo sapiens isoform TCP11c (TCP11) mRNA, complete cds; alternatively spliced.
AF536533 - Homo sapiens isoform TCP11d (TCP11) mRNA, complete cds; alternatively spliced.
HM005635 - Homo sapiens clone HTL-S-222n testis secretory sperm-binding protein Li 222n mRNA, complete cds.
AK057234 - Homo sapiens cDNA FLJ32672 fis, clone TESTI1000131, highly similar to Homo sapiens t-complex 11(TCP11), mRNA.
AK098590 - Homo sapiens cDNA FLJ25724 fis, clone TST05461, highly similar to Homo sapiens TCP11 (TCP11) mRNA.
AK302456 - Homo sapiens cDNA FLJ53244 complete cds, highly similar to Homo sapiens t-complex 11(TCP11), mRNA.
BC040003 - Homo sapiens t-complex 11 homolog (mouse), mRNA (cDNA clone MGC:48765 IMAGE:5741923), complete cds.
BC033729 - Homo sapiens t-complex 11 homolog (mouse), mRNA (cDNA clone MGC:45047 IMAGE:5167179), complete cds.
BC090050 - Homo sapiens t-complex 11 homolog (mouse), mRNA (cDNA clone MGC:111103 IMAGE:30387768), complete cds.
BC048418 - Homo sapiens t-complex 11 homolog (mouse), mRNA (cDNA clone MGC:57154 IMAGE:5298037), complete cds.
AK316403 - Homo sapiens cDNA, FLJ79302 complete cds, highly similar to Homo sapiens t-complex 11(TCP11), mRNA.
AK301778 - Homo sapiens cDNA FLJ55797 complete cds, highly similar to Homo sapiens t-complex 11(TCP11), mRNA.
AK302375 - Homo sapiens cDNA FLJ56011 complete cds, highly similar to Homo sapiens t-complex 11(TCP11), mRNA.
AK301975 - Homo sapiens cDNA FLJ58782 complete cds, highly similar to Homo sapiens t-complex 11(TCP11), mRNA.
AK302022 - Homo sapiens cDNA FLJ56171 complete cds, highly similar to Homo sapiens t-complex 11(TCP11), mRNA.
AK315078 - Homo sapiens cDNA, FLJ96033, Homo sapiens t-complex 11 (mouse) (TCP11), mRNA.
JD384871 - Sequence 365895 from Patent EP1572962.
JD438419 - Sequence 419443 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RCE9, B3KQ27, ENST00000373974.1, ENST00000373974.2, ENST00000373974.3, ENST00000373974.4, ENST00000373974.5, ENST00000373974.6, ENST00000373974.7, NM_001261818, Q8NF85, Q8WWU5, Q9NQZ9, Q9NR39, TCP11_HUMAN, uc011dsw.1, uc011dsw.2, uc011dsw.3
UCSC ID: ENST00000373974.8
RefSeq Accession: NM_001261818
Protein: Q8WWU5 (aka TCP11_HUMAN)
CCDS: CCDS59016.1, CCDS59017.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.