Human Gene ADAM2 (ENST00000521880.5) from GENCODE V44
Description: Homo sapiens ADAM metallopeptidase domain 2 (ADAM2), transcript variant 3, mRNA. (from RefSeq NM_001278114) RefSeq Summary (NM_001278114): This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded protein is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]. Gencode Transcript: ENST00000521880.5 Gencode Gene: ENSG00000104755.16 Transcript (Including UTRs) Position: hg38 chr8:39,744,031-39,838,227 Size: 94,197 Total Exon Count: 20 Strand: - Coding Region Position: hg38 chr8:39,744,860-39,838,185 Size: 93,326 Coding Exon Count: 19
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF08516 - ADAM cysteine-rich PF00200 - Disintegrin PF01562 - Reprolysin family propeptide PF01421 - Reprolysin (M12B) family zinc metalloprotease
ModBase Predicted Comparative 3D Structure on B4DWY7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
