Human Gene IMPA1 (ENST00000449740.6) from GENCODE V44
Description: Homo sapiens inositol monophosphatase 1 (IMPA1), transcript variant 2, mRNA. (from RefSeq NM_001144878) RefSeq Summary (NM_001144878): This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]. Gencode Transcript: ENST00000449740.6 Gencode Gene: ENSG00000133731.10 Transcript (Including UTRs) Position: hg38 chr8:81,659,262-81,686,283 Size: 27,022 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr8:81,659,351-81,685,915 Size: 26,565 Coding Exon Count: 9
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P29218
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC008381 - Homo sapiens inositol(myo)-1(or 4)-monophosphatase 1, mRNA (cDNA clone MGC:12464 IMAGE:3682305), complete cds. AF042729 - Homo sapiens lithium-sensitive myo-inositol monophosphatase A1 (IMPA1) mRNA, complete cds. BC009565 - Homo sapiens inositol(myo)-1(or 4)-monophosphatase 1, mRNA (cDNA clone MGC:12163 IMAGE:3682657), complete cds. AK297078 - Homo sapiens cDNA FLJ58981 complete cds, highly similar to Inositol monophosphatase (EC 3.1.3.25). JD206668 - Sequence 187692 from Patent EP1572962. AK300750 - Homo sapiens cDNA FLJ54837 complete cds, highly similar to Inositol monophosphatase (EC 3.1.3.25). JD252691 - Sequence 233715 from Patent EP1572962. JD491729 - Sequence 472753 from Patent EP1572962. JD243059 - Sequence 224083 from Patent EP1572962. HM005407 - Homo sapiens clone HTL-T-94 testicular tissue protein Li 94 mRNA, complete cds. X66922 - H.sapiens mRNA for myo-insositol monophosphatase. KJ905810 - Synthetic construct Homo sapiens clone ccsbBroadEn_15480 IMPA1 gene, encodes complete protein. AK312823 - Homo sapiens cDNA, FLJ93260, Homo sapiens inositol(myo)-1(or 4)-monophosphatase 1 (IMPA1), mRNA. HQ447127 - Synthetic construct Homo sapiens clone IMAGE:100070415; CCSB006214_04 inositol(myo)-1(or 4)-monophosphatase 1 (IMPA1) gene, encodes complete protein. KJ891472 - Synthetic construct Homo sapiens clone ccsbBroadEn_00866 IMPA1 gene, encodes complete protein. CU679403 - Synthetic construct Homo sapiens gateway clone IMAGE:100016955 5' read IMPA1 mRNA. JD368602 - Sequence 349626 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00562 - Inositol phosphate metabolism hsa01100 - Metabolic pathways hsa04070 - Phosphatidylinositol signaling system
Reactome (by CSHL, EBI, and GO)
Protein P29218 (Reactome details) participates in the following event(s):
R-HSA-1855211 I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol R-HSA-1855154 I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol R-HSA-1855210 I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1483249 Inositol phosphate metabolism R-HSA-1430728 Metabolism