Human Gene HS6ST2 (ENST00000521489.5) from GENCODE V44
Description: Homo sapiens heparan sulfate 6-O-sulfotransferase 2 (HS6ST2), transcript variant L, mRNA. (from RefSeq NM_001077188) RefSeq Summary (NM_001077188): Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migration. This gene encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate to HS. Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific structures and functions. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000521489.5 Gencode Gene: ENSG00000171004.19 Transcript (Including UTRs) Position: hg38 chrX:132,627,970-132,961,395 Size: 333,426 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chrX:132,628,223-132,958,602 Size: 330,380 Coding Exon Count: 5
ID:H6ST2_HUMAN DESCRIPTION: RecName: Full=Heparan-sulfate 6-O-sulfotransferase 2; Short=HS6ST-2; EC=2.8.2.-; FUNCTION: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. CATALYTIC ACTIVITY: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate. SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Potential). SIMILARITY: Belongs to the sulfotransferase 6 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96MM7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
