Human Gene TP53AIP1 (ENST00000458238.6) from GENCODE V44
Description: Homo sapiens tumor protein p53 regulated apoptosis inducing protein 1 (TP53AIP1), transcript variant 2, mRNA. (from RefSeq NM_001195195) RefSeq Summary (NM_001195195): This gene is specifically expressed in the thymus, and encodes a protein that is localized to the mitochondrion. The expression of this gene is inducible by p53, and it is thought to play an important role in mediating p53-dependent apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]. Gencode Transcript: ENST00000458238.6 Gencode Gene: ENSG00000120471.16 Transcript (Including UTRs) Position: hg38 chr11:128,934,731-128,942,927 Size: 8,197 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr11:128,935,037-128,937,818 Size: 2,782 Coding Exon Count: 3
ID:TPIP1_HUMAN DESCRIPTION: RecName: Full=p53-regulated apoptosis-inducing protein 1; Short=p53AIP1; FUNCTION: May play an important role in mediating p53/TP53- dependent apoptosis. SUBCELLULAR LOCATION: Mitochondrion. TISSUE SPECIFICITY: Only found to be expressed in thymus. INDUCTION: By p53/TP53.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q9HCN2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary