Human Gene KLRF2 (ENST00000535540.1) from GENCODE V44
  Description: Homo sapiens killer cell lectin like receptor F2 (KLRF2), mRNA. (from RefSeq NM_001190765)
Gencode Transcript: ENST00000535540.1
Gencode Gene: ENSG00000256797.1
Transcript (Including UTRs)
   Position: hg38 chr12:9,881,489-9,895,833 Size: 14,345 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr12:9,881,596-9,895,833 Size: 14,238 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:9,881,489-9,895,833)mRNA (may differ from genome)Protein (207 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMGIneXtProtOMIMPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KLRF2_HUMAN
DESCRIPTION: RecName: Full=Killer cell lectin-like receptor subfamily F member 2; Short=Lectin-like receptor F2; AltName: Full=Activating coreceptor NKp65;
FUNCTION: C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A.
SUBUNIT: Homodimer; non disulfide-linked. Interacts with CLEC2A.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein.
PTM: N-glycosylated.
SIMILARITY: Contains 1 C-type lectin domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KLRF2
Diseases sorted by gene-association score: glaucoma 1, open angle, e (1)

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.91 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 1.76 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.70107-0.137 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001304 - C-type_lectin
IPR016186 - C-type_lectin-like
IPR016187 - C-type_lectin_fold

Pfam Domains:
PF00059 - Lectin C-type domain

ModBase Predicted Comparative 3D Structure on D3W0D1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
      
      
    WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0042803 protein homodimerization activity

Biological Process:
GO:0043320 natural killer cell degranulation
GO:0050663 cytokine secretion

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  GQ398770 - Homo sapiens killer cell lectin-like receptor subfamily F member 2 (KLRF2) mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: D3W0D1, KLRF2_HUMAN, NM_001190765, uc021quy.1
UCSC ID: ENST00000535540.1
RefSeq Accession: NM_001190765
Protein: D3W0D1 (aka KLRF2_HUMAN)
CCDS: CCDS53743.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.