Human Gene USP17L28 (ENST00000504543.1) from GENCODE V44
  Description: Homo sapiens ubiquitin specific peptidase 17 like family member 28 (USP17L28), mRNA. (from RefSeq NM_001242331)
Gencode Transcript: ENST00000504543.1
Gencode Gene: ENSG00000231051.3
Transcript (Including UTRs)
   Position: hg38 chr4:9,348,893-9,350,485 Size: 1,593 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg38 chr4:9,348,893-9,350,485 Size: 1,593 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA-Seq ExpressionMicroarray Expression
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:9,348,893-9,350,485)mRNA (may differ from genome)Protein (530 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMGIneXtProtPubMedReactome
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: UBP17_HUMAN
DESCRIPTION: RecName: Full=Ubiquitin carboxyl-terminal hydrolase 17; EC=3.4.19.12; AltName: Full=Deubiquitinating enzyme 17; AltName: Full=Ubiquitin thioesterase 17; AltName: Full=Ubiquitin-specific-processing protease 17;
FUNCTION: Functions in cell apoptosis. Cleaves ubiquitin fusion protein substrates. May also bind hyaluronan and RNA.
CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
SUBCELLULAR LOCATION: Nucleus, nucleolus.
TISSUE SPECIFICITY: Expressed in heart, brain, liver and skeletal muscle.
SIMILARITY: Belongs to the peptidase C19 family. USP17 subfamily.
CAUTION: The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of USP17. It is present with an interindividual variation in copy number and between 20 to 103 copies can be found both on chromosome 4 and chromosome 8.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.00 RPKM in Adipose - Subcutaneous
Total median expression: 0.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006861 - HABP4_PAIRBP1-bd
IPR018200 - Pept_C19ubi-hydrolase_C_CS
IPR001394 - Peptidase_C19

Pfam Domains:
PF04774 - Hyaluronan / mRNA binding family
PF00443 - Ubiquitin carboxyl-terminal hydrolase

ModBase Predicted Comparative 3D Structure on Q0WX57
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0004843 thiol-dependent ubiquitin-specific protease activity
GO:0005540 hyaluronic acid binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity

Biological Process:
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006915 apoptotic process
GO:0016579 protein deubiquitination
GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:1904037 positive regulation of epithelial cell apoptotic process

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum


-  Descriptions from all associated GenBank mRNAs
  BC156290 - Synthetic construct Homo sapiens clone IMAGE:100061686, MGC:190074 deubiquitinating enzyme 3 (DUB3) mRNA, encodes complete protein.
BC157073 - Synthetic construct Homo sapiens clone IMAGE:100063311, MGC:190736 deubiquitinating enzyme 3 (DUB3) mRNA, encodes complete protein.
BC100993 - Homo sapiens deubiquitinating enzyme 3-like, mRNA (cDNA clone IMAGE:40005800).
AF544011 - Homo sapiens deubiquitinating enzyme DUB1 (DUB1) mRNA, complete cds.
AY509884 - Homo sapiens deubiquitinating enzyme 3 (DUB3) mRNA, complete cds.
BC100991 - Homo sapiens deubiquitinating enzyme 3-like, mRNA (cDNA clone IMAGE:40005796).
BC100992 - Homo sapiens deubiquitinating enzyme 3-like, mRNA (cDNA clone IMAGE:40005797).

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q0WX57 (Reactome details) participates in the following event(s):

R-HSA-5696600 USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1
R-HSA-6782820 USP17 deubiquitinates SUDS3
R-HSA-5689880 Ub-specific processing proteases
R-HSA-5688426 Deubiquitination
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: A8MRA9, NM_001242331, Q0WX56, Q0WX57, Q3BEM1, UBP17_HUMAN, uc021xlq.1, USP17, USP17A, USP17H, USP17I, USP17J, USP17K, USP17L, USP17M
UCSC ID: ENST00000504543.1
RefSeq Accession: NM_001242330
Protein: Q0WX57 (aka UBP17_HUMAN)
CCDS: CCDS59469.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.