Human Gene PGM3 (ENST00000512866.5) from GENCODE V44
Description: Homo sapiens phosphoglucomutase 3 (PGM3), transcript variant 4, mRNA. (from RefSeq NM_001199919) RefSeq Summary (NM_001199919): This gene encodes a member of the phosphohexose mutase family. The encoded protein mediates both glycogen formation and utilization by catalyzing the interconversion of glucose-1-phosphate and glucose-6-phosphate. A non-synonymous single nucleotide polymorphism in this gene may play a role in resistance to diabetic nephropathy and neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]. Gencode Transcript: ENST00000512866.5 Gencode Gene: ENSG00000013375.17 Transcript (Including UTRs) Position: hg38 chr6:83,166,130-83,193,231 Size: 27,102 Total Exon Count: 14 Strand: - Coding Region Position: hg38 chr6:83,166,387-83,191,012 Size: 24,626 Coding Exon Count: 13
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF02878 - Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PF02879 - Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PF00408 - Phosphoglucomutase/phosphomannomutase, C-terminal domain
ModBase Predicted Comparative 3D Structure on O95394
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK021676 - Homo sapiens cDNA FLJ11614 fis, clone HEMBA1004015. AK023685 - Homo sapiens cDNA FLJ13623 fis, clone PLACE1010965. AK225363 - Homo sapiens mRNA for phosphoglucomutase 3 variant, clone: HEP16446. AL117443 - Homo sapiens mRNA; cDNA DKFZp434B187 (from clone DKFZp434B187). AK023709 - Homo sapiens cDNA FLJ13647 fis, clone PLACE1011332, highly similar to Homo sapiens N-acetylglucosamine-phosphate mutase mRNA. AK001365 - Homo sapiens cDNA FLJ10503 fis, clone NT2RP2000422, highly similar to Homo sapiens N-acetylglucosamine-phosphate mutase mRNA. AF102265 - Homo sapiens N-acetylglucosamine-phosphate mutase mRNA, complete cds. AB032081 - Homo sapiens HsAGM1 mRNA for phosphoacetylglucosamine mutase, complete cds. AF180371 - Homo sapiens N-acetylglucosamine-phosphate mutase mRNA, complete cds. BC001258 - Homo sapiens phosphoglucomutase 3, mRNA (cDNA clone MGC:5002 IMAGE:3451677), complete cds. AK023432 - Homo sapiens cDNA FLJ13370 fis, clone PLACE1000653, highly similar to Phosphoacetylglucosamine mutase (EC 5.4.2.3). AK301867 - Homo sapiens cDNA FLJ55543 complete cds, highly similar to Phosphoacetylglucosamine mutase (EC 5.4.2.3). AK314512 - Homo sapiens cDNA, FLJ95330, Homo sapiens phosphoglucomutase 3 (PGM3), mRNA. KJ897325 - Synthetic construct Homo sapiens clone ccsbBroadEn_06719 PGM3 gene, encodes complete protein.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00520 - Amino sugar and nucleotide sugar metabolism
Reactome (by CSHL, EBI, and GO)
Protein O95394 (Reactome details) participates in the following event(s):
R-HSA-446185 Isomerization of GlcNAc6P to GlcNAc1P R-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine R-HSA-446219 Synthesis of substrates in N-glycan biosythesis R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins