Human Gene LONP1 (ENST00000590729.5) from GENCODE V44
Description: lon peptidase 1, mitochondrial (from HGNC LONP1) RefSeq Summary (NM_004793): This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]. Gencode Transcript: ENST00000590729.5 Gencode Gene: ENSG00000196365.12 Transcript (Including UTRs) Position: hg38 chr19:5,691,955-5,719,849 Size: 27,895 Total Exon Count: 18 Strand: - Coding Region Position: hg38 chr19:5,692,032-5,719,790 Size: 27,759 Coding Exon Count: 18
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.