Human Gene TRAPPC6A (ENST00000588062.5) from GENCODE V44
Description: Homo sapiens trafficking protein particle complex 6A (TRAPPC6A), transcript variant 4, mRNA. (from RefSeq NM_001270893) RefSeq Summary (NM_001270893): This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. Loss of expression of the related gene in mouse affects coat and eye pigmentation, suggesting that the encoded protein may be involved in melanosome biogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]. Gencode Transcript: ENST00000588062.5 Gencode Gene: ENSG00000007255.10 Transcript (Including UTRs) Position: hg38 chr19:45,162,928-45,178,237 Size: 15,310 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr19:45,163,954-45,178,218 Size: 14,265 Coding Exon Count: 4
ID:TPC6A_HUMAN DESCRIPTION: RecName: Full=Trafficking protein particle complex subunit 6A; Short=TRAPP complex subunit 6A; FUNCTION: May play a role in vesicular transport during the biogenesis of melanosomes (By similarity). SUBUNIT: Part of the multisubunit TRAPP (transport protein particle) complex. Heterodimer with TRAPPC3. The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L. Interacts with TRAPPC2L. SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network (By similarity). Endoplasmic reticulum (By similarity). SIMILARITY: Belongs to the TRAPP small subunits family. BET3 subfamily. SEQUENCE CAUTION: Sequence=AAC62259.1; Type=Erroneous initiation; Sequence=AAF28967.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75865
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
