Human Gene ZNF211 (ENST00000299871.9) from GENCODE V44
  Description: Homo sapiens zinc finger protein 211 (ZNF211), transcript variant 10, mRNA. (from RefSeq NM_001322306)
RefSeq Summary (NM_001265597): This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. This protein may play a role in developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
Gencode Transcript: ENST00000299871.9
Gencode Gene: ENSG00000121417.14
Transcript (Including UTRs)
   Position: hg38 chr19:57,633,216-57,642,737 Size: 9,522 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr19:57,633,347-57,642,181 Size: 8,835 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:57,633,216-57,642,737)mRNA (may differ from genome)Protein (629 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMalacardsMGIneXtProtOMIM
PubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN211_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 211; AltName: Full=Zinc finger protein C2H2-25;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 12 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.
SEQUENCE CAUTION: Sequence=AAA93261.1; Type=Erroneous initiation; Sequence=AAH34351.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAD93084.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.79 RPKM in Pituitary
Total median expression: 319.47 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -51.30131-0.392 Picture PostScript Text
3' UTR -163.50556-0.294 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF01352 - KRAB box

ModBase Predicted Comparative 3D Structure on Q13398
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AB209847 - Homo sapiens mRNA for zinc finger protein 211 isoform 2 variant protein.
AB209273 - Homo sapiens mRNA for zinc finger protein 211 isoform 2 variant protein.
AK294869 - Homo sapiens cDNA FLJ60513 complete cds, highly similar to Homo sapiens zinc finger protein 211 (ZNF211), transcript variant 2, mRNA.
BC018138 - Homo sapiens zinc finger protein 211, mRNA (cDNA clone IMAGE:3850482).
AK296942 - Homo sapiens cDNA FLJ58580 complete cds, highly similar to Homo sapiens zinc finger protein 211 (ZNF211), transcript variant 2, mRNA.
AK297047 - Homo sapiens cDNA FLJ58584 complete cds, highly similar to Homo sapiens zinc finger protein 211 (ZNF211), transcript variant 1, mRNA.
AK304666 - Homo sapiens cDNA FLJ58412 complete cds, highly similar to Homo sapiens zinc finger protein 211 (ZNF211), transcript variant 2, mRNA.
BC110856 - Homo sapiens zinc finger protein 211, mRNA (cDNA clone MGC:131841 IMAGE:6527651), complete cds.
BC034351 - Homo sapiens zinc finger protein 211, mRNA (cDNA clone IMAGE:4752213), partial cds.
AK026941 - Homo sapiens cDNA: FLJ23288 fis, clone HEP10025, highly similar to HSU38904 Human zinc finger protein C2H2-25 mRNA.
BC089440 - Homo sapiens zinc finger protein 211, mRNA (cDNA clone IMAGE:30558815), partial cds.
KJ902118 - Synthetic construct Homo sapiens clone ccsbBroadEn_11512 ZNF211 gene, encodes complete protein.
JD077063 - Sequence 58087 from Patent EP1572962.
JD369839 - Sequence 350863 from Patent EP1572962.
JD214176 - Sequence 195200 from Patent EP1572962.
JD528971 - Sequence 509995 from Patent EP1572962.
JD360688 - Sequence 341712 from Patent EP1572962.
JD048336 - Sequence 29360 from Patent EP1572962.
U38904 - Human zinc finger protein C2H2-25 mRNA, complete cds.
JD036956 - Sequence 17980 from Patent EP1572962.
JD175686 - Sequence 156710 from Patent EP1572962.
JD073417 - Sequence 54441 from Patent EP1572962.
JD164169 - Sequence 145193 from Patent EP1572962.
JD400943 - Sequence 381967 from Patent EP1572962.
JD181376 - Sequence 162400 from Patent EP1572962.
JD348059 - Sequence 329083 from Patent EP1572962.
JD413241 - Sequence 394265 from Patent EP1572962.
JD059203 - Sequence 40227 from Patent EP1572962.
JD263980 - Sequence 245004 from Patent EP1572962.
JD251217 - Sequence 232241 from Patent EP1572962.
JD234591 - Sequence 215615 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q13398 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: B4DH10, B4DLC9, B4E3C9, B9ZVS7, ENST00000299871.1, ENST00000299871.2, ENST00000299871.3, ENST00000299871.4, ENST00000299871.5, ENST00000299871.6, ENST00000299871.7, ENST00000299871.8, NM_001322306, Q05BQ7, Q13398, Q2TAL7, Q59EG4, Q59G36, Q5EBL6, uc031rng.1, uc031rng.2, ZN211_HUMAN
UCSC ID: ENST00000299871.9
RefSeq Accession: NM_001265597
Protein: Q13398 (aka ZN211_HUMAN or Z211_HUMAN)
CCDS: CCDS58686.1, CCDS74468.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.