Mouse Gene Top2a (U75592) Description and Page Index
  Description: 16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130086A08 product:topoisomerase (DNA) II alpha, full insert sequence.
Transcript (Including UTRs)
   Position: mm8 chr11:98,809,571-98,826,691 Size: 17,121 Total Exon Count: 23 Strand: -
Coding Region
   Position: mm8 chr11:98,809,894-98,815,356 Size: 5,463 Coding Exon Count: 8 

Page IndexSequence and LinksCTDMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesMethods
Data last updated: 2006-02-27

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:98,809,571-98,826,691)mRNA (may differ from genome)Protein (325 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAllen Brain Atlas
BioGPSCGAPEnsemblEntrez GeneGeneCardsPubMed
Stanford SOURCEUniProtKB

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from GNF1M Mouse Chip

    
     
      
       
     
    
   
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Rinn et. al Sex Gene Expression Data on MOE430A Chip

n/a
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GNF Expression Atlas Data from U74a Mouse Chip

        
     
    
    
    
   
    
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Affymetrix All Exon Microarrays

           
Ratios

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -585.582114-0.277 Picture PostScript Text
3' UTR -73.14323-0.226 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012542 - DTHCT

Pfam Domains:
PF08070 - DTHCT (NUC029) region

ModBase Predicted Comparative 3D Structure on Q3UUS6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBank Ensembl   
Protein Sequence Protein Sequence   
Alignment Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005524 ATP binding

Biological Process:
GO:0006265 DNA topological change


-  Descriptions from all associated GenBank mRNAs
  D12513 - Mus musculus mRNA for DNA topoisomerase II, complete cds.
U01919 - Mus musculus DBA/2 DNA topoisomerase IIalpha fusion protein mRNA, partial cds.
BC094326 - Mus musculus topoisomerase (DNA) II alpha, mRNA (cDNA clone IMAGE:6415166), complete cds.
U01915 - Mus musculus DNA topoisomerase IIalpha mRNA, partial cds.
AK138079 - Mus musculus 16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130086A08 product:topoisomerase (DNA) II alpha, full insert sequence.
AK033321 - Mus musculus 15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030493B08 product:topoisomerase (DNA) II alpha, full insert sequence.
AK082477 - Mus musculus 0 day neonate cerebellum cDNA, RIKEN full-length enriched library, clone:C230053N18 product:topoisomerase (DNA) II alpha, full insert sequence.
AK161381 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4930521A06 product:topoisomerase (DNA) II alpha, full insert sequence.
AK169723 - Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430013D24 product:topoisomerase (DNA) II alpha, full insert sequence.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
m_DNAfragmentPathway - Apoptotic DNA fragmentation and tissue homeostasis

-  Other Names for This Gene
  Alternate Gene Symbols: NM_011623, TOP2
UCSC ID: AK033321
RefSeq Accession: NM_011623
Protein: Q3UUS6

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.