ID:C4BPA_MOUSE DESCRIPTION: RecName: Full=C4b-binding protein; Short=C4bp; Flags: Precursor; FUNCTION: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component. SUBUNIT: Homoheptamer; not covalently linked. Mouse lacks the beta chain of C4BP. INTERACTION: Q13873:BMPR2 (xeno); NbExp=3; IntAct=EBI-527325, EBI-527196; SUBCELLULAR LOCATION: Secreted. SIMILARITY: Contains 6 Sushi (CCP/SCR) domains. CAUTION: It is uncertain whether Met-1 or Met-44 is the initiator. SEQUENCE CAUTION: Sequence=AAA37312.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P08607
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.