Mouse Gene C4bp (G170568) Description and Page Index
  Description: C4b-binding protein precursor (C4bp).
Transcript (Including UTRs)
   Position: mm8 chr1:132,463,558-132,489,135 Size: 25,578 Total Exon Count: 10 Strand: -
Coding Region
   Position: mm8 chr1:132,463,752-132,484,843 Size: 21,092 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesMethods
Data last updated: 2006-02-27

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:132,463,558-132,489,135)mRNA (may differ from genome)Protein (469 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
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-  Comments and Description Text from UniProtKB
  ID: C4BPA_MOUSE
DESCRIPTION: RecName: Full=C4b-binding protein; Short=C4bp; Flags: Precursor;
FUNCTION: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component.
SUBUNIT: Homoheptamer; not covalently linked. Mouse lacks the beta chain of C4BP.
INTERACTION: Q13873:BMPR2 (xeno); NbExp=3; IntAct=EBI-527325, EBI-527196;
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Contains 6 Sushi (CCP/SCR) domains.
CAUTION: It is uncertain whether Met-1 or Met-44 is the initiator.
SEQUENCE CAUTION: Sequence=AAA37312.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from GNF1M Mouse Chip

    
     
      
       
     
    
   
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Rinn et. al Sex Gene Expression Data on MOE430A Chip

        
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GNF Expression Atlas Data from U74a Mouse Chip

        
     
    
    
    
   
    
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Affymetrix All Exon Microarrays

           
Ratios

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -41.10159-0.258 Picture PostScript Text
3' UTR -36.90194-0.190 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016060 - Complement_control_module
IPR000436 - Sushi_SCR_CCP

Pfam Domains:
PF00084 - Sushi repeat (SCR repeat)

ModBase Predicted Comparative 3D Structure on P08607
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologGenome BrowserNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
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GenBankRGDEnsembl WormBase 
Protein Sequence Protein Sequence Protein Sequence 
Alignment Alignment Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0002376 immune system process
GO:0006958 complement activation, classical pathway
GO:0045087 innate immune response

Cellular Component:
GO:0005576 extracellular region


-  Descriptions from all associated GenBank mRNAs
  AB094485 - Mus musculus C4bpa mRNA for C4b-binding protein alpha-chain, complete cds, tissue_type:liver.
AK149477 - Mus musculus adult male liver tumor cDNA, RIKEN full-length enriched library, clone:C730023F21 product:complement component 4 binding protein, full insert sequence.
AK136735 - Mus musculus adult male epididymis cDNA, RIKEN full-length enriched library, clone:9230110E19 product:complement component 4 binding protein, full insert sequence.
AB094486 - Mus musculus C4bpa mRNA for C4b-binding protein alpha-chain, complete cds, tissue_type: epididymis.
M17122 - Mouse C4b-binding protein mRNA, complete cds.
AK162345 - Mus musculus adult male epididymis cDNA, RIKEN full-length enriched library, clone:9230005C07 product:complement component 4 binding protein, full insert sequence.
BC012257 - Mus musculus complement component 4 binding protein, mRNA (cDNA clone MGC:18586 IMAGE:4163203), complete cds.
AK149468 - Mus musculus adult male liver tumor cDNA, RIKEN full-length enriched library, clone:C730019C09 product:complement component 4 binding protein, full insert sequence.
AK050344 - Mus musculus adult male liver tumor cDNA, RIKEN full-length enriched library, clone:C730039N23 product:hypothetical protein, full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04610 - Complement and coagulation cascades

-  Other Names for This Gene
  Alternate Gene Symbols: AB094485, AB094486, AK136735, AK149468, AK149477, AK162345, C4bpa, M17122, NM_007576
UCSC ID: BC012257
RefSeq Accession: NM_007576
Protein: P08607 (aka C4BPA_MOUSE)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.