Mouse Gene Lrrk1 (G223953) Description and Page Index
  Description: Lrrk1 protein.
Transcript (Including UTRs)
   Position: mm8 chr7:66,137,699-66,267,240 Size: 129,542 Total Exon Count: 28 Strand: -
Coding Region
   Position: mm8 chr7:66,141,137-66,221,864 Size: 80,728 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2006-02-27

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:66,137,699-66,267,240)mRNA (may differ from genome)Protein (1149 aa)
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-  Comments and Description Text from UniProtKB
  ID: LRRK1_MOUSE
DESCRIPTION: RecName: Full=Leucine-rich repeat serine/threonine-protein kinase 1; EC=2.7.11.1;
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Magnesium or manganese (By similarity).
ENZYME REGULATION: Binding of GTP stimulates kinase activity (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
PTM: Autophosphorylated (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.
SIMILARITY: Contains 4 ANK repeats.
SIMILARITY: Contains 13 LRR (leucine-rich) repeats.
SIMILARITY: Contains 1 protein kinase domain.
SIMILARITY: Contains 1 Roc domain.
SEQUENCE CAUTION: Sequence=AAH27199.1; Type=Erroneous initiation; Sequence=BAC36341.1; Type=Erroneous initiation; Sequence=BAC39743.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from GNF1M Mouse Chip

    
     
      
       
     
    
   
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Absolute

Rinn et. al Sex Gene Expression Data on MOE430A Chip

        
Ratios
        
Absolute

GNF Expression Atlas Data from U74b Mouse Chip

          
Ratios
          
Absolute

Affymetrix All Exon Microarrays

           
Ratios

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -120.50297-0.406 Picture PostScript Text
3' UTR -594.101519-0.391 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom
IPR011009 - Kinase-like_dom
IPR001611 - Leu-rich_rpt
IPR025875 - Leu-rich_rpt_2_copies
IPR003591 - Leu-rich_rpt_typical-subtyp
IPR013684 - MIRO-like
IPR000719 - Prot_kinase_cat_dom
IPR020859 - ROC_GTPase

Pfam Domains:
PF12796 - Ankyrin repeats (3 copies)
PF00560 - Leucine Rich Repeat
PF12799 - Leucine Rich repeats (2 copies)
PF08477 - Ras of Complex, Roc, domain of DAPkinase
PF00069 - Protein kinase domain

ModBase Predicted Comparative 3D Structure on Q3UHC2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologGenome BrowserNo orthologGenome BrowserGenome Browser
Gene Details   Gene DetailsGene Details
Gene Sorter   Gene SorterGene Sorter
GenBank Ensembl WormBaseSGD
Protein Sequence Protein Sequence Protein SequenceProtein Sequence
Alignment Alignment AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0016310 phosphorylation
GO:0036035 osteoclast development
GO:0045453 bone resorption
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1902533 positive regulation of intracellular signal transduction

Cellular Component:
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AK129441 - Mus musculus mRNA for mKIAA1790 protein.
BC072664 - Mus musculus leucine-rich repeat kinase 1, mRNA (cDNA clone MGC:99993 IMAGE:30543489), complete cds.
AK147469 - Mus musculus cDNA, RIKEN full-length enriched library, clone:M5C1048P20 product:leucine-rich repeat kinase 1, full insert sequence.
AK051264 - Mus musculus 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130026O16 product:hypothetical Leucine-rich repeat/Ankyrin-repeat/ATP/GTP-binding site motif A (P-loop)/Leucine-rich repeat, typical subtype containing protein, full insert sequence.
AK086795 - Mus musculus 0 day neonate lung cDNA, RIKEN full-length enriched library, clone:E030001K11 product:hypothetical RNI-like structure containing protein, full insert sequence.
BC066159 - Mus musculus leucine-rich repeat kinase 1, mRNA (cDNA clone IMAGE:30472176), partial cds.
BC080819 - Mus musculus leucine-rich repeat kinase 1, mRNA (cDNA clone IMAGE:30143856), partial cds.
AK154395 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630026P10 product:leucine-rich repeat kinase 1, full insert sequence.
AK081849 - Mus musculus 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130082A22 product:hypothetical protein, full insert sequence.
AK076432 - Mus musculus 0 day neonate head cDNA, RIKEN full-length enriched library, clone:4832415J17 product:hypothetical Protein kinase-like (PK-like) structure containing protein, full insert sequence.
BC027199 - Mus musculus leucine-rich repeat kinase 1, mRNA (cDNA clone IMAGE:4224922), complete cds.
AK040153 - Mus musculus 0 day neonate thymus cDNA, RIKEN full-length enriched library, clone:A430070G24 product:hypothetical Tyrosine protein kinase/Serine/Threonine protein kinase/Eukaryotic protein kinase containing protein, full insert sequence.
AK040108 - Mus musculus 0 day neonate thymus cDNA, RIKEN full-length enriched library, clone:A430062H02 product:unclassifiable, full insert sequence.
AK171849 - Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830014K24 product:hypothetical Cysteine-rich region profile containing protein, full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_146191
UCSC ID: BC072664
RefSeq Accession: NM_146191
Protein: Q3UHC2 (aka LRRK1_MOUSE)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.