Mouse Gene Lrrk1 (G223953) Description and Page Index
Description: Lrrk1 protein.
Transcript (Including UTRs)
Position: mm8 chr7:66,137,699-66,267,240 Size: 129,542 Total Exon Count: 28 Strand: -
Position: mm8 chr7:66,141,137-66,221,864 Size: 80,728 Coding Exon Count: 23
Data last updated: 2006-02-27
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Leucine-rich repeat serine/threonine-protein kinase 1; EC=184.108.40.206;
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium or manganese (By similarity). ENZYME REGULATION: Binding of GTP stimulates kinase activity (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). PTM: Autophosphorylated (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. SIMILARITY: Contains 4 ANK repeats. SIMILARITY: Contains 13 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 protein kinase domain. SIMILARITY: Contains 1 Roc domain. SEQUENCE CAUTION: Sequence=AAH27199.1; Type=Erroneous initiation; Sequence=BAC36341.1; Type=Erroneous initiation; Sequence=BAC39743.1; Type=Erroneous initiation;
Comparative Toxicogenomics Database (CTD)
Microarray Expression Data
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom
IPR011009 - Kinase-like_dom
IPR001611 - Leu-rich_rpt
IPR025875 - Leu-rich_rpt_2_copies
IPR003591 - Leu-rich_rpt_typical-subtyp
IPR013684 - MIRO-like
IPR000719 - Prot_kinase_cat_dom
IPR020859 - ROC_GTPase
Pfam Domains: PF12796 - Ankyrin repeats (3 copies)
PF00560 - Leucine Rich Repeat
PF12799 - Leucine Rich repeats (2 copies)
PF08477 - Ras of Complex, Roc, domain of DAPkinase
PF00069 - Protein kinase domain
ModBase Predicted Comparative 3D Structure on Q3UHC2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK129441 - Mus musculus mRNA for mKIAA1790 protein. BC072664 - Mus musculus leucine-rich repeat kinase 1, mRNA (cDNA clone MGC:99993 IMAGE:30543489), complete cds. AK147469 - Mus musculus cDNA, RIKEN full-length enriched library, clone:M5C1048P20 product:leucine-rich repeat kinase 1, full insert sequence. AK051264 - Mus musculus 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130026O16 product:hypothetical Leucine-rich repeat/Ankyrin-repeat/ATP/GTP-binding site motif A (P-loop)/Leucine-rich repeat, typical subtype containing protein, full insert sequence. AK086795 - Mus musculus 0 day neonate lung cDNA, RIKEN full-length enriched library, clone:E030001K11 product:hypothetical RNI-like structure containing protein, full insert sequence. BC066159 - Mus musculus leucine-rich repeat kinase 1, mRNA (cDNA clone IMAGE:30472176), partial cds. BC080819 - Mus musculus leucine-rich repeat kinase 1, mRNA (cDNA clone IMAGE:30143856), partial cds. AK154395 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630026P10 product:leucine-rich repeat kinase 1, full insert sequence. AK081849 - Mus musculus 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130082A22 product:hypothetical protein, full insert sequence. AK076432 - Mus musculus 0 day neonate head cDNA, RIKEN full-length enriched library, clone:4832415J17 product:hypothetical Protein kinase-like (PK-like) structure containing protein, full insert sequence. BC027199 - Mus musculus leucine-rich repeat kinase 1, mRNA (cDNA clone IMAGE:4224922), complete cds. AK040153 - Mus musculus 0 day neonate thymus cDNA, RIKEN full-length enriched library, clone:A430070G24 product:hypothetical Tyrosine protein kinase/Serine/Threonine protein kinase/Eukaryotic protein kinase containing protein, full insert sequence. AK040108 - Mus musculus 0 day neonate thymus cDNA, RIKEN full-length enriched library, clone:A430062H02 product:unclassifiable, full insert sequence. AK171849 - Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830014K24 product:hypothetical Cysteine-rich region profile containing protein, full insert sequence.
Other Names for This Gene
Alternate Gene Symbols: NM_146191 UCSC ID: BC072664 RefSeq Accession: NM_146191
(aka LRRK1_MOUSE) Q3UHC2
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.