D. melanogaster Gene dock (CG3727-RC) Description and Page Index
  Description: CG3727-PB, isoform B (CG3727-PC, isoform C) (LD42588p).
Transcript (Including UTRs)
   Position: dm3 chr2L:825,964-833,245 Size: 7,282 Total Exon Count: 6 Strand: +
Coding Region
   Position: dm3 chr2L:829,536-831,923 Size: 2,388 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsMicroarray ExpressionProtein StructureOther Species
GO AnnotationsFlyBase RolesPhenotypesSynonymsIn SitusmRNA Descriptions
Other NamesMethods
Data last updated: 2008-10-21

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2L:825,964-833,245)mRNAProtein (548 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaFlyBasePubMed
RefSeqUniProtKB

-  Comments and Description Text from UniProtKB
  ID: Q9VPU1_DROME
DESCRIPTION: SubName: Full=Dreadlocks, isoform B; SubName: Full=Dreadlocks, isoform C; SubName: Full=LD42588p;
SIMILARITY: Contains 3 SH3 domains.

-  Microarray Expression Data
 
Expression ratio colors:

Arbeitman et al. 2002 Life-Cycle Expression Data

     
          
          
     
     
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000980 - SH2
IPR001452 - SH3_domain

Pfam Domains:
PF00017 - SH2 domain
PF00018 - SH3 domain

ModBase Predicted Comparative 3D Structure on Q9VPU1
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene DetailsGene DetailsGene Details Gene Details 
Gene SorterGene SorterGene Sorter Gene Sorter 
  RGDEnsemblWormBase 
  Protein SequenceProtein SequenceProtein Sequence 
  AlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005158 insulin receptor binding
GO:0005070 SH3/SH2 adaptor activity

Biological Process:
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007411 axon guidance
GO:0007409 axonogenesis
GO:0008286 insulin receptor signaling pathway

Cellular Component:
GO:0005737 cytoplasm


-  FlyBase Biological Roles [Jan. 2006 data]
 
  • dock facilitates synapse formation by the RP3 motoneuron and is required for guidance of some interneuronal axons. dock mediated signalling may be important in remodelling the RP3 growth cone's cytoskelton. (Desai et al., 1999, Development 126(7): 1527--1535)

-  FlyBase Phenotypes of Various Alleles of Gene [Jan. 2006 data]
 
  • Mutations in dock disrupt photoreceptor cell axon guidance and targeting. Genetic mosaic analysis and cell-type-specific expression of dock transgenes demonstrate dock is required in receptor cells for proper innervation. (Garrity et al., 1996, Cell 85(5): 639--650)
  • Loss of zygotic dock function causes a selective delay in synapse formation by the RP3 motoneuron at the cleft between muscles 7 and 6. In late stage 16 mutant embryos these muscles often lack innervation. By the third larval instar muscles have become innervated by RP3. dock mutants also show subtle defects in the CNS longitudinal axon pathway. (Desai et al., 1999, Development 126(7): 1527--1535)
  • Interacts genetically with: Pak (data from dockunspecified) (Hing et al., 1999, Cell 97(7): 853--863)
  • Interacts genetically with: msn (data from dock04723, dock13421, dockScerUAS.cRa, dockW225K.ScerUAS, dockW48K.ScerUAS) (Ruan et al., 1999, Neuron 24(3): 595--605)
  • Interacts genetically with: Hem (data from dock13421) (Hummel et al., 2000, Genes Dev. 14(7): 863--873)
  • Interacts genetically with: trio (data from dock04723, dock4) (Newsome et al., 2000, Cell 101(3): 283--294)
  • Interacts genetically with: Dscam (data from dock3) (Schmucker et al., 2000, Cell 101(6): 671--684)
  • Interacts genetically with: msn (data from dock04723) (Su et al., 2000, Molec. Cell. Biol. 20(13): 4736--4744)
  • Interacts genetically with: Ras85D (data from dock04723) (Schnorr et al., 2001, Genetics 159(2): 609--622)
  • Interacts genetically with: InR (data from dock04723, dock13421) (Song et al., 2003, Science 300(5618): 502--505)
Allele dock3:
  • Phenotypic class: lethal | pupal stage | recessive Phenotypic class: uncoordinated | recessive Phenotype manifest in: photoreceptor cell & axon Allele class: amorph Some homozygotes survive to adulthood. These flies are sluggish and uncoordinated, dying within a few days after eclosion. Homozygous third instar larvae exhibit defects in receptor cell fasciculation, targeting and retinotopy. (Garrity et al., 1996, Cell 85(5): 639--650)
  • Phenotypic class: neuroanatomy defective | embryonic stage | recessive Phenotypic class: (with dock13421) neuroanatomy defective | embryonic stage Phenotype manifest in: longitudinal connective Phenotype manifest in: embryonic/larval somatic muscle Phenotype manifest in: RP3 neuron & synapse In dock13421/dock3 mutant embryos longitudinal connectives are more wavy and more varied in thickness than wild type and the outermost one is occasionally interrupted. There are low penetrance defects in muscle organization. The muscle phenotype is not affected further in embryos lacking both maternal and zygotic dock activity. dock13421/dock3 mutant embryos (and homozygotes of both alleles) show a variable absence of the synapse between RP3 and muscles 7 and 6. Outgrowth of RP3 from the CNS is normal. Synapse formation eventually occurs, but is delayed. No ectopic synapses occur. This phenotype is identical to that of lbmY13. (Desai et al., 1999, Development 126(7): 1527--1535)
  • Phenotype manifest in: Bolwig's nerve Phenotype manifest in: (with Df(2R)EW60) Bolwig's nerve About 5% of heterozygotes exhibit some Bolwig's nerve targeting defects. About 44% of Df(2R)EW60/dock3 embryos exhibit some Bolwig's nerve targeting defects. (Schmucker et al., 2000, Cell 101(6): 671--684)
Allele dock4:
  • Phenotype manifest in: (with dock04723) photoreceptor cell & axon 14% of dock4/dock04723 animals show defects in photoreceptor axon projection, having a "medulla bypass" phenotype. (Schmucker et al., 2000, Cell 101(6): 671--684)
  • Phenotype manifest in: (with dock04723) photoreceptor cell & axon 14% of dock4/dock04723 animals show defects in photoreceptor axon projection, having a "medulla bypass" phenotype. (Newsome et al., 2000, Cell 101(3): 283--294)
Allele dock04723:
  • Phenotypic class: lethal | pupal stage | recessive Phenotypic class: uncoordinated | recessive Phenotype manifest in: medulla | somatic clone Phenotype manifest in: neuron | somatic clone Phenotype manifest in: photoreceptor cell | somatic clone Phenotype manifest in: photoreceptor cell & axon Phenotype manifest in: lamina plexus Phenotype manifest in: medulla Phenotype manifest in: larval optic stalk Phenotype manifest in: larval outer optic anlage Phenotype manifest in: larval inner optic anlage Phenotype manifest in: lobula Allele class: amorph Some homozygotes survive to adulthood. These flies are sluggish and uncoordinated, dying within a few days after eclosion. Homozygous third instar larvae exhibit defects in receptor cell fasciculation, targeting and retinotopy. The plexus of receptor cell terminals in the lamina is uneven. Bundles do project into the medulla where they establish an uneven array of terminals. Grouping of axons in the optic stalk is also aberrant. The pattern of proliferation of optic lobe neuroblasts and lamina precursors is indistinguishable from wild type. Lamina and neurons are disorganized, this is a likely consequence of defects in receptor cell innervation rather than an intrinsic defect in neurons or glia. Structure of the medulla neuropile is abnormal. Mosaic heads reveal that projections of mutant fibers in the medulla terminal field are abnormal, gaps are present in the R7 terminal field and fibers cross between columns. Some R1-R6 axons underlying mutant patches project into the medulla. Most ommatidia in mosaic patches are indistinguishable from wild type. A small number of receptor cells are missing, this may reflect a weak defect in cell survival due to abnormal innervation. (Garrity et al., 1996, Cell 85(5): 639--650)
  • Phenotype manifest in: lamina receptor cell R1 Phenotype manifest in: lamina receptor cell R2 Phenotype manifest in: lamina receptor cell R3 Phenotype manifest in: lamina receptor cell R4 Phenotype manifest in: lamina receptor cell R5 Phenotype manifest in: lamina receptor cell R6 R cell projections in both the lamina and medulla are disorganized. Large axon bundles form: bundles contain R1-R6 neurons that fail to terminate in the lamina. (Rao and Zipursky, 1998, Proc. Natl. Acad. Sci. USA 95(5): 2077--2082)
  • Phenotypic class: lethal | pupal stage | recessive Phenotypic class: lethal | embryonic stage | maternal effect | recessive Phenotypic class: neuroanatomy defective | embryonic stage | recessive Phenotype manifest in: RP3 neuron & synapse Mutant embryos show a variable absence of the synapse between RP3 and muscles 7 and 6. Outgrowth of RP3 from the CNS is normal. Synapse formation eventually occurs, but is delayed. No ectopic synapses occur. Maternal loss of dock expression enhances the CNS longitudinal axon defects, but not the RP3 synapse formation delay. (Desai et al., 1999, Development 126(7): 1527--1535)
  • Phenotypic class: lethal | recessive (Spradling et al., 1999, Genetics 153(1): 135--177)
  • Phenotype manifest in: photoreceptor cell R1 & axon Phenotype manifest in: photoreceptor cell R2 & axon Phenotype manifest in: photoreceptor cell R3 & axon Phenotype manifest in: photoreceptor cell R4 & axon Phenotype manifest in: photoreceptor cell R5 & axon Phenotype manifest in: photoreceptor cell R6 & axon Phenotype manifest in: lamina Phenotype manifest in: medulla Phenotype manifest in: photoreceptor cell & growth cone Many R1-R6 photoreceptor cell axons migrate ectopically into the medulla in homozygous larvae, passing their normal target (the lamina), generating gaps in the lamina R1-R6 termination site. Fasciculation and growth cone morphology of the photoreceptor cell axons is also altered. Abnormal large axon bundles are seen in both the lamina and medulla. The phenotype is completely penetrant. (Ruan et al., 1999, Neuron 24(3): 595--605)
  • Phenotype manifest in: (with dock4) photoreceptor cell & axon 14% of dock4/dock04723 animals show defects in photoreceptor axon projection, having a "medulla bypass" phenotype. (Newsome et al., 2000, Cell 101(3): 283--294)
  • Phenotype manifest in: Bolwig's nerve Phenotype manifest in: (with dock13421) Bolwig's nerve About 5% of heterozygotes exhibit some Bolwig's nerve targeting defects. In dock04723/dock13421 embryos, either the entire Bolwig's Nerve, or a subset of its axons project to ectopic positions. These defects have over a 90% penetrance. (Schmucker et al., 2000, Cell 101(6): 671--684)
  • Phenotype manifest in: photoreceptor & axon Phenotype manifest in: photoreceptor cell R7 & axon Phenotype manifest in: medulla Phenotype manifest in: photoreceptor & axon | somatic clone Phenotype manifest in: photoreceptor cell R7 & axon | somatic clone Phenotype manifest in: medulla | somatic clone The removal of dock04723 function in the eye by making clones in a Minute background causes the same phenotype as homozygosity for dock04723. The R7 and R8 axons in dock04723 mutants lack expanded growth cones and fail to form an even array in the medulla. (Su et al., 2000, Molec. Cell. Biol. 20(13): 4736--4744)
  • When mutant somatic clones are made in the border cells no effect is seen. (Duchek et al., 2001, Cell 107(1): 17--26)
  • Phenotypic class: neuroanatomy defective Phenotypic class: neuroanatomy defective | somatic clone | cell non-autonomous Phenotypic class: neuroanatomy defective | pupal stage Phenotype manifest in: antennal lobe Phenotype manifest in: antennal lobe & neuropil Phenotype manifest in: antennal glomerulus DM2 Phenotype manifest in: antennal glomerulus DM3 Phenotype manifest in: antennal lobe | somatic clone | cell non-autonomous Phenotype manifest in: adult antennal nerve & pupa Phenotype manifest in: antennal glomerulus & pupa | ectopic Phenotype manifest in: glial cell & antennal lobe Phenotype manifest in: neuron & antennal lobe In dock04723 homozygous adults the antennal lobes are small and mis-shapen compared to wild-type, and have amorphous neuropil. Antennal glomeruli DM2 and DM3 are severely mis-shapen or split into smaller structures that are scattered randomly around the antennal lobe. The integrity and position of VA11m is unaffected, but it is enlarged and extends into the domains of surrounding glomeruli, in most cases completely engulfing the adjacent VA1d. Projection neurons and glial cells differentiate normally in antennal lobes of the mutants, but dendritic arborization of the projection neurons is more diffuse than in wild-type, and the number of glial processes is somewhat reduced. The development of neurons within the antennae appears normal. When somatic clones of dock04723 are induced in the eye-antennal disc, but not the brain (using ScerFLP1ey.PN), the antennal lobes are severely mis-shapen and aglomerular, and olfactory neuron axons terminate in ectopic locations. In dock04723 homozygous pupae 30 hours after puparium formation (hAPF) the pattern of olfactory neuron projections from the antennae is normal. However, once in the antennal lobe, the axonal trajectories are clearly abnormal: instead of forming characteristic tracks, the fibers interweave to form a dense mat. Occasionally these axons leave the antennal lobe, and instead extend aberrantly into dorsal brain regions. Most axonal branches in the antennal lobe fail to reach their destination, instead terminating in ectopic mis-shapen glomeruli. Occasionally extra axon branches are seen, but they are short and not associated with ectopic glomeruli. (Ang et al., 2003, Development 130(7): 1307--1316)
  • Phenotypic class: neuroanatomy defective | somatic clone Phenotype manifest in: larval optic lobe | somatic clone Phenotype manifest in: medulla | somatic clone In mosaic larvae in which homozygous clones have been induced in the eye, photoreceptor cell axons fail to target the optic lobe properly; gaps and clumps of axons are seen. The pattern of R7 and R8 projections in the medulla shows defects in mosaic adults in which homozygous clones have been induced in the eye; crossing of fibers, uninnervated regions and gaps in the R7 layer are seen. Heterozygotes have normal photoreceptor cell projections in the medulla. (Song et al., 2003, Science 300(5618): 502--505)
  • The initial stages of mesoderm spreading during mesoderm morphogenesis are normal in mutant embryos. (Wilson et al., 2005, Development 132(3): 491--501)
Allele dock13421:
  • Phenotypic class: lethal | pupal stage | recessive Phenotypic class: uncoordinated | recessive Phenotype manifest in: photoreceptor cell & axon Allele class: amorph Some homozygotes survive to adulthood. These flies are sluggish and uncoordinated, dying within a few days after eclosion. Homozygous third instar larvae exhibit defects in receptor cell fasciculation, targeting and retinotopy. Receptor cell axons terminate at different depths in the developing lamina and form clumps of terminals instead of an even array. Bundles project from these regions into the medulla. Some bundles project along abnormal paths. (Garrity et al., 1996, Cell 85(5): 639--650)
  • Phenotypic class: lethal | pupal stage | recessive Phenotypic class: lethal | embryonic stage | maternal effect | recessive Phenotypic class: neuroanatomy defective | embryonic stage | recessive Phenotypic class: (with dock3) neuroanatomy defective | embryonic stage Phenotype manifest in: longitudinal connective Phenotype manifest in: embryonic/larval somatic muscle Phenotype manifest in: RP3 neuron & synapse Phenotype manifest in: longitudinal connective | maternal effect In dock13421/dock3 mutant embryos longitudinal connectives are more wavy and more varied in thickness than wild type and the outermost one is occasionally interrupted. There are low penetrance defects in muscle organization. The muscle phenotype is not affected further in embryos lacking both maternal and zygotic dock activity. dock13421/dock3 mutant embryos (and homozygotes of both alleles) show a variable absence of the synapse between RP3 and muscles 7 and 6. Outgrowth of RP3 from the CNS is normal. Synapse formation eventually occurs, but is delayed. No ectopic synapses occur. This phenotype is identical to that of lbmY13. Maternal loss of dock expression enhances the CNS longitudinal axon defects, but not the RP3 synapse formation delay. (Desai et al., 1999, Development 126(7): 1527--1535)
  • Phenotype manifest in: longitudinal connective Phenotype manifest in: ventral nerve cord commissure Phenotype manifest in: VUM neuron Phenotype manifest in: photoreceptor cell & axon Phenotype manifest in: lamina neuropil The growth of retinula axons into the brain is disrupted in homozygous larvae, leading to a disruption of the lamina neuropile organization. Homozygous embryos show a reduction in the longitudinal connectives and a slight fusion of the segmental commissures. The VUM neurons do not project normally. (Hummel et al., 2000, Genes Dev. 14(7): 863--873)
  • Phenotype manifest in: (with dock04723) Bolwig's nerve In dock04723/dock13421 embryos, either the entire Bolwig's Nerve, or a subset of its axons project to ectopic positions. These defects have over a 90% penetrance. (Schmucker et al., 2000, Cell 101(6): 671--684)
  • Phenotypic class: neuroanatomy defective Phenotype manifest in: lamina anlage Phenotype manifest in: medulla anlage Phenotype manifest in: larval optic lobe Photoreceptor cell axons fail to target the optic lobe properly in mutant larvae; crossing of axons, gaps in the lamina and blunt ended termination point in the medulla are seen. (Song et al., 2003, Science 300(5618): 502--505)
  • When mutant clones are made in the developing eye, no R-cell precursor nuclear migration phenotype was seen. (Houalla et al., 2005, Mech. Dev. 122(1): 97--108)
Allele dockk13421:
  • Phenotypic class: lethal | recessive (BDGP Project Members, 1994-1999, computer file)
  • Phenotypic class: lethal | recessive (Spradling et al., 1999, Genetics 153(1): 135--177)
Allele dockk16610:
  • Phenotypic class: lethal | recessive (Spradling et al., 1999, Genetics 153(1): 135--177)
  • Phenotypic class: lethal | recessive (BDGP Project Members, 1994-1999, computer file)
Allele dockunspecified:
  • Phenotype manifest in: photoreceptor cell & axon Phenotype manifest in: lamina Phenotype manifest in: medulla R cell axons form large abnormal fascicles in the optic ganglia. This leads to hyperinnervated regions separated by areas lacking innervation in the lamina and the medulla. In addition to disrupting targeting, R cell axons terminals are thick and blunt ended. (Hing et al., 1999, Cell 97(7): 853--863)
  • Phenotype manifest in: photoreceptor cell & axon | somatic clone Defects in pathfinding by photoreceptor axons are seen in mosaic animals in which virtually the entire retina is homozygous for dockunspecified while other tissues are heterozygous (clones generated using the "eyFLP" system); 77% of brain hemispheres of mosaic adults show a "medulla bypass" phenotype. (Newsome et al., 2000, Cell 101(3): 283--294)
Allele dock&Dgr;SH2.ScerUAS:
  • Mode of assay: In transgenic Drosophila (intraspecific) (Newsome et al., 2000, Cell 101(3): 283--294)
  • Mode of assay: In transgenic Drosophila (intraspecific) (Rao and Zipursky, 1998, Proc. Natl. Acad. Sci. USA 95(5): 2077--2082)
Allele dockAct5C.T:ZzzzHis6:
  • Mode of assay: Drosophila cell culture (Schmucker et al., 2000, Cell 101(6): 671--684)
  • Mode of assay: Drosophila cell culture (Worby et al., 2001, J. Biol. Chem. 276(45): 41782--41789)
  • Mode of assay: Drosophila cell culture (Worby et al., 2002, J. Biol. Chem. 277(11): 9422--9428)
Allele dockdsRNA.cCa:
  • Mode of assay: Drosophila cell culture (Worby et al., 2002, J. Biol. Chem. 277(11): 9422--9428)
  • Mode of assay: Drosophila cell culture (Christensen and Tye, 2003, Molec. Biol. Cell 14(6): 2206--2215)
Allele dockdsRNA.cKa:
  • Mode of assay: Drosophila cell culture S2R+ cells treated with dockdsRNA.cKa dsRNA do not show a change in morphology or actin organization. (Christensen and Tye, 2003, Molec. Biol. Cell 14(6): 2206--2215)
  • Mode of assay: Drosophila cell culture S2R+ cells treated with dockdsRNA.cKa dsRNA do not show a change in morphology or actin organization. (Kunda et al., 2003, Curr. Biol. 13(21): 1867--1875)
Allele dockdsRNA.cWa:
  • Mode of assay: Drosophila cell culture (Worby et al., 2001, J. Biol. Chem. 276(45): 41782--41789)
  • Mode of assay: Drosophila cell culture (Muda et al., 2002, Biochem. J. 366(1): 73--77)
Allele dockGMR.PG:
  • Phenotypic class: wild-type Mode of assay: In transgenic Drosophila (intraspecific) (Garrity et al., 1996, Cell 85(5): 639--650)
  • Phenotypic class: wild-type (Schmucker et al., 2000, Cell 101(6): 671--684)
Allele dockhs.PG:
  • Phenotypic class: wild-type Mode of assay: In transgenic Drosophila (intraspecific) (Schmucker et al., 2000, Cell 101(6): 671--684)
  • Phenotypic class: wild-type Mode of assay: In transgenic Drosophila (intraspecific) (Garrity et al., 1996, Cell 85(5): 639--650)
Allele dockR336Q.ScerUAS:
  • Mode of assay: In transgenic Drosophila (intraspecific) (Garrity et al., 1996, Cell 85(5): 639--650)
  • Mode of assay: In transgenic Drosophila (intraspecific) (Rao and Zipursky, 1998, Proc. Natl. Acad. Sci. USA 95(5): 2077--2082)
Allele dockScerUAS.cRa:
  • Mode of assay: In transgenic Drosophila (intraspecific) (Rao and Zipursky, 1998, Proc. Natl. Acad. Sci. USA 95(5): 2077--2082)
  • Expression of dockScerUAS.cRa under the control of ScerGAL4GMR.PF in a wild-type background has no effect on photoreceptor cell projections. (Ruan et al., 1999, Neuron 24(3): 595--605)
Allele dockW151K.ScerUAS:
  • Mode of assay: In transgenic Drosophila (intraspecific) (Ang et al., 2003, Development 130(7): 1307--1316)
  • Mode of assay: In transgenic Drosophila (intraspecific) (Rao and Zipursky, 1998, Proc. Natl. Acad. Sci. USA 95(5): 2077--2082)
Allele dockW225K.R336Q.ScerUAS:
  • Mode of assay: In transgenic Drosophila (intraspecific) (Ang et al., 2003, Development 130(7): 1307--1316)
  • Mode of assay: In transgenic Drosophila (intraspecific) (Rao and Zipursky, 1998, Proc. Natl. Acad. Sci. USA 95(5): 2077--2082)
Allele dockW225K.ScerUAS:
  • Mode of assay: In transgenic Drosophila (intraspecific) (Rao and Zipursky, 1998, Proc. Natl. Acad. Sci. USA 95(5): 2077--2082)
  • Mode of assay: In transgenic Drosophila (intraspecific) (Rao and Zipursky, 1998, Proc. Natl. Acad. Sci. USA 95(5): 2077--2082)
Allele dockW48K.R336Q.ScerUAS:
  • Mode of assay: In transgenic Drosophila (intraspecific) (Ang et al., 2003, Development 130(7): 1307--1316)
  • Mode of assay: In transgenic Drosophila (intraspecific) (Rao and Zipursky, 1998, Proc. Natl. Acad. Sci. USA 95(5): 2077--2082)
Allele dockW48K.ScerUAS:
  • Mode of assay: In transgenic Drosophila (intraspecific) (Rao and Zipursky, 1998, Proc. Natl. Acad. Sci. USA 95(5): 2077--2082)
  • Mode of assay: In transgenic Drosophila (intraspecific) (Rao and Zipursky, 1998, Proc. Natl. Acad. Sci. USA 95(5): 2077--2082)
Allele dockW48K.W151K.W225K.ScerUAS:
  • Mode of assay: In transgenic Drosophila (intraspecific) (Ang et al., 2003, Development 130(7): 1307--1316)
  • Mode of assay: In transgenic Drosophila (intraspecific) (Rao and Zipursky, 1998, Proc. Natl. Acad. Sci. USA 95(5): 2077--2082)
Allele dockW48K.W225K.&Dgr;SH2.ScerUAS:
  • Mode of assay: In transgenic Drosophila (intraspecific) (Rao and Zipursky, 1998, Proc. Natl. Acad. Sci. USA 95(5): 2077--2082)
  • Mode of assay: In transgenic Drosophila (intraspecific) (Rao and Zipursky, 1998, Proc. Natl. Acad. Sci. USA 95(5): 2077--2082)
Allele dockW48K.W225K.R336Q.ScerUAS:
  • Mode of assay: In transgenic Drosophila (intraspecific) (Rao and Zipursky, 1998, Proc. Natl. Acad. Sci. USA 95(5): 2077--2082)
  • Mode of assay: In transgenic Drosophila (intraspecific) (Rao and Zipursky, 1998, Proc. Natl. Acad. Sci. USA 95(5): 2077--2082)
Allele dockW48K.W225K.ScerUAS:
  • Mode of assay: In transgenic Drosophila (intraspecific) (Rao and Zipursky, 1998, Proc. Natl. Acad. Sci. USA 95(5): 2077--2082)
  • Mode of assay: In transgenic Drosophila (intraspecific) (Rao and Zipursky, 1998, Proc. Natl. Acad. Sci. USA 95(5): 2077--2082)

-  FlyBase Synonyms for Gene and Its Alleles [Jan. 2006 data]
  Symbol: dock Name: dreadlocks BDGP: CG3727-RC FlyBase: FBgn0010583
Synonyms: CG3727, Dm0447, Dock, Dock04723, Nck, dck, dck3, dck3, doc, dock+, dock04723, dock13421, dock3, dock4, dockAct5C.T:ZzzzHis6, dockEP1242, dockGMR.PG, dockP04723, dockP1, dockP13421, dockP2, dockR336Q.ScerUAS, dockR336Q.UAS, dockScerUAS.cRa, dockUAS.cRa, dockW151K.ScerUAS, dockW151K.UAS, dockW225K.R336Q.ScerUAS, dockW225K.R336Q.UAS, dockW225K.ScerUAS, dockW225K.UAS, dockW48K.R336Q.ScerUAS, dockW48K.R336Q.UAS, dockW48K.ScerUAS, dockW48K.UAS, dockW48K.W151K.W225K.ScerUAS, dockW48K.W151K.W225K.UAS, dockW48K.W225K.R336Q.ScerUAS, dockW48K.W225K.R336Q.UAS, dockW48K.W225K.ScerUAS, dockW48K.W225K.UAS, dockW48K.W225K.deltaSH2.ScerUAS, dockW48K.W225K.deltaSH2.UAS, dockdeltaSH2.ScerUAS, dockdeltaSH2.UAS, dockdsRNA.cCa, dockdsRNA.cKa, dockdsRNA.cWa, dockhs.PG, dockk13421, dockk16610, dockunspecified, l(2)04723, l(2)k13421

-  BDGP Expression In Situ Images
  In situ images for BDGP gene CG3727 (dock, FlyBase gene FBgn0010583) are available from the BDGP Gene Expression project.
Number of images: 15
Number of body parts: 13
EST: LD42588
DGC Plate: UG.36
Plate position: 93

-  Descriptions from all associated GenBank mRNAs
  U57816 - Drosophila melanogaster SH2/SH3 adaptor protein (Dock) mRNA, complete cds.
AY119614 - Drosophila melanogaster LD42588 full insert cDNA.
FJ631433 - Synthetic construct Drosophila melanogaster clone BO09221 encodes dock-RA.
FJ636318 - Synthetic construct Drosophila melanogaster clone BS08921 encodes dock-RA.

-  Other Names for This Gene
  UCSC ID: CG3727-RC
RefSeq Accession: NM_057628
Protein: Q9VPU1

-  FlyBase Genes Methods, Credits, and Data Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.