Mouse Gene Grid2ip (ENSMUST00000010969.15) from GENCODE VM30
  Description: Mus musculus glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1 (Grid2ip), transcript variant 2, mRNA. (from RefSeq NM_133355)
Gencode Transcript: ENSMUST00000010969.15
Gencode Gene: ENSMUSG00000010825.18
Transcript (Including UTRs)
   Position: mm39 chr5:143,349,663-143,377,553 Size: 27,891 Total Exon Count: 21 Strand: +
Coding Region
   Position: mm39 chr5:143,349,717-143,377,223 Size: 27,507 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2022-06-02 09:33:23

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr5:143,349,663-143,377,553)mRNA (may differ from genome)Protein (1024 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Delphilin; AltName: Full=Glutamate receptor, ionotropic, delta 2-interacting protein 1;
FUNCTION: Postsynaptic scaffolding protein at the Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.
SUBUNIT: Interacts with C-terminus of the glutamate receptor GRID2 via PDZ domain. Isoform 2 interacts also with Profilin-2/PFN2 and with the monocarboxylate transporter SLC16A7 via PDZ domain. The interaction of isoform 2 with GRID2 is dependent on GRID2 phosphorylation by PKA.
SUBCELLULAR LOCATION: Isoform 2: Cell junction, synapse, postsynaptic cell membrane. Cell projection, dendritic spine. Note=Localized to the postsynaptic junction site of the parallel fiber-Purkinje cell synapse. Highly present in the dendritic spines.
SUBCELLULAR LOCATION: Isoform 3: Cell junction, synapse. Cell projection, dendritic spine. Cell membrane; Lipid-anchor (Potential). Note=Localized at the dendritic spines, but also in dendritic shafts apart fron spines.
TISSUE SPECIFICITY: Isoform 1 is expressed in the cerebellum, but not in the cerebral cortex. Isoform 2 is expressed in the cell body of purkinge cells of the cerebellum and weakly expressed in the cerebrum and the brainstem as well as various nuclei of the thalamus. Isoform 2 is highly expressed in the cerebral cortex than in the cerebellum. Isoform 3 is expressed in the cerebellum and cerebrum.
DEVELOPMENTAL STAGE: Isoform 3 expression is maintained throughout cerebellar development, while isoform 2 expression gradually decrease following the first postnatal week.
DOMAIN: PDZ 1 domain is responsible for cytoplasmic clustering of isoform 1.
PTM: Isoform 2 is palmitoylated. Palmitoylation of isoform 2 is necessary for the enhanced cell surface expression of GRID2, and is also responsible for the accumulation of isoform 2 within dendritic spines. Isoform 1 and isoform 2 are differentially localized, probably modulating GRID2 signaling in neurons.
MISCELLANEOUS: Isoform 1 shows a punctate distribution throughout the cytoplasm when expressed in COS cells, whereas isoform 2 is enriched at the edges of the plasma membranes. When expressed in cultured hippocampal neurons, isoform 1 forms clusters mainly in the dendritic shafts, whereas isoform 2 is preferentially expressed in spines.
SIMILARITY: Contains 1 FH2 (formin homology 2) domain.
SIMILARITY: Contains 2 PDZ (DHR) domains.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -10.9054-0.202 Picture PostScript Text
3' UTR -132.90330-0.403 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003104 - Actin-bd_FH2/DRF_autoreg
IPR015425 - FH2_actin-bd
IPR001478 - PDZ

Pfam Domains:
PF02181 - Formin Homology 2 Domain
PF00595 - PDZ domain (Also known as DHR or GLGF)

ModBase Predicted Comparative 3D Structure on Q0QWG9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0007216 G-protein coupled glutamate receptor signaling pathway
GO:0030036 actin cytoskeleton organization
GO:0060292 long term synaptic depression

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030054 cell junction
GO:0042995 cell projection
GO:0043197 dendritic spine
GO:0045202 synapse
GO:0045211 postsynaptic membrane

-  Descriptions from all associated GenBank mRNAs
  DQ193535 - Mus musculus L-delphilin mRNA, complete cds, alternatively spliced.
AF099933 - Mus musculus GluR-delta2 philic-protein (Delphilin) mRNA, complete cds.
AY377835 - Mus musculus delphilin mRNA, exon 1a and partial cds, alternatively spliced.
BC075624 - Mus musculus glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1, mRNA (cDNA clone MGC:92989 IMAGE:6841572), complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: ENSMUST00000010969.1, ENSMUST00000010969.10, ENSMUST00000010969.11, ENSMUST00000010969.12, ENSMUST00000010969.13, ENSMUST00000010969.14, ENSMUST00000010969.2, ENSMUST00000010969.3, ENSMUST00000010969.4, ENSMUST00000010969.5, ENSMUST00000010969.6, ENSMUST00000010969.7, ENSMUST00000010969.8, ENSMUST00000010969.9, GRD2I_MOUSE, NM_133355, Q0QWG9, Q6DID0, Q9ESJ5, uc009ake.1, uc009ake.2
UCSC ID: ENSMUST00000010969.15
RefSeq Accession: NM_133355
Protein: Q0QWG9 (aka GRD2I_MOUSE)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.