Mouse Gene Arg1 (ENSMUST00000020161.10) from GENCODE VM30
  Description: Mus musculus arginase, liver (Arg1), mRNA. (from RefSeq NM_007482)
Gencode Transcript: ENSMUST00000020161.10
Gencode Gene: ENSMUSG00000019987.10
Transcript (Including UTRs)
   Position: mm39 chr10:24,791,119-24,803,382 Size: 12,264 Total Exon Count: 8 Strand: -
Coding Region
   Position: mm39 chr10:24,791,508-24,803,266 Size: 11,759 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2022-06-02 09:33:23

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr10:24,791,119-24,803,382)mRNA (may differ from genome)Protein (323 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
ReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Arginase-1; EC=; AltName: Full=Liver-type arginase; AltName: Full=Type I arginase;
CATALYTIC ACTIVITY: L-arginine + H(2)O = L-ornithine + urea.
COFACTOR: Binds 2 manganese ions per subunit (By similarity).
PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.
SUBUNIT: Homotrimer (By similarity).
SIMILARITY: Belongs to the arginase family.
SEQUENCE CAUTION: Sequence=BAE28901.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.40116-0.322 Picture PostScript Text
3' UTR -77.90389-0.200 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR014033 - Arginase
IPR006035 - Ureohydrolase
IPR023696 - Ureohydrolase_domain
IPR020855 - Ureohydrolase_Mn_BS

Pfam Domains:
PF00491 - Arginase family

ModBase Predicted Comparative 3D Structure on Q61176
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologGenome BrowserGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
 RGDEnsembl WormBaseSGD
Protein SequenceProtein SequenceProtein Sequence Protein SequenceProtein Sequence
AlignmentAlignmentAlignment AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004053 arginase activity
GO:0016787 hydrolase activity
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
GO:0030145 manganese ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0000050 urea cycle
GO:0001889 liver development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002250 adaptive immune response
GO:0002376 immune system process
GO:0006525 arginine metabolic process
GO:0007565 female pregnancy
GO:0007568 aging
GO:0009611 response to wounding
GO:0009635 response to herbicide
GO:0010042 response to manganese ion
GO:0010043 response to zinc ion
GO:0010269 response to selenium ion
GO:0010963 regulation of L-arginine import
GO:0014075 response to amine
GO:0019547 arginine catabolic process to ornithine
GO:0030324 lung development
GO:0032496 response to lipopolysaccharide
GO:0032964 collagen biosynthetic process
GO:0033189 response to vitamin A
GO:0033197 response to vitamin E
GO:0042130 negative regulation of T cell proliferation
GO:0042493 response to drug
GO:0042832 defense response to protozoan
GO:0043200 response to amino acid
GO:0043434 response to peptide hormone
GO:0045087 innate immune response
GO:0046007 negative regulation of activated T cell proliferation
GO:0046686 response to cadmium ion
GO:0048545 response to steroid hormone
GO:0048678 response to axon injury
GO:0051597 response to methylmercury
GO:0060056 mammary gland involution
GO:0060135 maternal process involved in female pregnancy
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0070207 protein homotrimerization
GO:0070301 cellular response to hydrogen peroxide
GO:0070965 positive regulation of neutrophil mediated killing of fungus
GO:0071222 cellular response to lipopolysaccharide
GO:0071353 cellular response to interleukin-4
GO:0071377 cellular response to glucagon stimulus
GO:0071549 cellular response to dexamethasone stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:2000552 negative regulation of T-helper 2 cell cytokine production

Cellular Component:
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body

-  Descriptions from all associated GenBank mRNAs
  U88541 - Mus musculus blastocyst arginase homolog mRNA, 3'UTR sequence.
AK149471 - Mus musculus adult male liver tumor cDNA, RIKEN full-length enriched library, clone:C730019N20 product:arginase 1, liver, full insert sequence.
BC013341 - Mus musculus arginase, liver, mRNA (cDNA clone MGC:13983 IMAGE:4163626), complete cds.
AK171417 - Mus musculus B6-derived CD11 +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F730211I08 product:arginase 1, liver, full insert sequence.
BC050005 - Mus musculus arginase, liver, mRNA (cDNA clone MGC:58976 IMAGE:3990246), complete cds.
U51805 - Mus musculus arginase mRNA, complete cds.
CT010173 - Mus musculus full open reading frame cDNA clone RZPDo836B0650D for gene Arg1, Arginase 1, liver; complete cds, incl. stopcodon.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
ARG-PRO-PWY - arginine degradation VI (arginase 2 pathway)
ARGASEDEG-PWY - arginine degradation I (arginase pathway)
CITRULBIO-PWY - citrulline biosynthesis
PWY-4984 - urea cycle
PWY-5004 - superpathway of citrulline metabolism

Reactome (by CSHL, EBI, and GO)

Protein Q61176 (Reactome details) participates in the following event(s):

R-MMU-6798749 Exocytosis of specific granule lumen proteins
R-MMU-6798751 Exocytosis of azurophil granule lumen proteins
R-MMU-70569 arginine + H2O => ornithine + urea [ARG1]
R-MMU-6798695 Neutrophil degranulation
R-MMU-70635 Urea cycle
R-MMU-168249 Innate Immune System
R-MMU-351202 Metabolism of polyamines
R-MMU-168256 Immune System
R-MMU-71291 Metabolism of nitrogenous molecules
R-MMU-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: ARGI1_MOUSE, ENSMUST00000020161.1, ENSMUST00000020161.2, ENSMUST00000020161.3, ENSMUST00000020161.4, ENSMUST00000020161.5, ENSMUST00000020161.6, ENSMUST00000020161.7, ENSMUST00000020161.8, ENSMUST00000020161.9, NM_007482, Q3TB74, Q3UEL0, Q4FK78, Q61176, Q80VI4, uc007erg.1, uc007erg.2, uc007erg.3, uc007erg.4
UCSC ID: ENSMUST00000020161.10
RefSeq Accession: NM_007482
Protein: Q61176 (aka ARGI1_MOUSE or ARGI_MOUSE)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.