Mouse Gene Ifngr1 (ENSMUST00000020188.12)
  Description: Mus musculus interferon gamma receptor 1 (Ifngr1), mRNA. (from RefSeq NM_010511)
Gencode Transcript: ENSMUST00000020188.12
Gencode Gene: ENSMUSG00000020009.13
Transcript (Including UTRs)
   Position: mm10 chr10:19,591,949-19,610,229 Size: 18,281 Total Exon Count: 7 Strand: +
Coding Region
   Position: mm10 chr10:19,592,086-19,609,688 Size: 17,603 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:19,591,949-19,610,229)mRNA (may differ from genome)Protein (477 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: INGR1_MOUSE
DESCRIPTION: RecName: Full=Interferon gamma receptor 1; Short=IFN-gamma receptor 1; Short=IFN-gamma-R1; AltName: CD_antigen=CD119; Flags: Precursor;
FUNCTION: Receptor for interferon gamma. Two receptors bind one interferon gamma dimer.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
PTM: Phosphorylated at Ser/Thr residues.
SIMILARITY: Belongs to the type II cytokine receptor family.
SIMILARITY: Contains 2 fibronectin type-III domains.
SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
SEQUENCE CAUTION: Sequence=AAA37895.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D000082 Acetaminophen
  • D008070 Lipopolysaccharides
  • D013749 Tetrachlorodibenzodioxin
  • C007262 deoxynivalenol
  • C049325 1,2-dithiol-3-thione
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D000171 Acrolein
  • D016604 Aflatoxin B1
          more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -59.50137-0.434 Picture PostScript Text
3' UTR -144.50541-0.267 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003961 - Fibronectin_type3
IPR013783 - Ig-like_fold
IPR021126 - Interferon_gamma_pox/mammal
IPR008355 - Interferon_gamma_rcpt_asu

Pfam Domains:
PF01108 - Tissue factor
PF07140 - Interferon gamma receptor (IFNGR1)
PF09294 - Interferon-alpha/beta receptor, fibronectin type III

SCOP Domains:
49265 - Fibronectin type III

ModBase Predicted Comparative 3D Structure on P15261
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004896 cytokine receptor activity
GO:0019955 cytokine binding

Biological Process:
GO:0019221 cytokine-mediated signaling pathway
GO:0051607 defense response to virus

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0031982 vesicle


-  Descriptions from all associated GenBank mRNAs
  LF197932 - JP 2014500723-A/5435: Polycomb-Associated Non-Coding RNAs.
AK087525 - Mus musculus 0 day neonate eyeball cDNA, RIKEN full-length enriched library, clone:E130311K10 product:interferon gamma receptor, full insert sequence.
M26711 - Murine interferon-gamma receptor (IFN-gamma) mRNA, complete cds.
M28233 - Mouse interferon-gamma receptor mRNA, complete cds.
AK169593 - Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430001E04 product:interferon gamma receptor, full insert sequence.
J05265 - Mouse interferon gamma receptor mRNA, complete cds.
AK151079 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830022K15 product:interferon gamma receptor, full insert sequence.
AK159359 - Mus musculus osteoclast-like cell cDNA, RIKEN full-length enriched library, clone:I420018E01 product:interferon gamma receptor, full insert sequence.
AF128216 - Mus musculus strain B10.S/J interferon gamma receptor (Ifngr) mRNA, complete cds.
AF128217 - Mus musculus strain SJL/J interferon gamma receptor (Ifngr) mRNA, complete cds.
AY157836 - Mus musculus strain C3H/HeJ interferon gamma receptor (Ifngr) mRNA, complete cds.
AY157837 - Mus musculus strain DBA/2J interferon gamma receptor (Ifngr) mRNA, complete cds.
AK153347 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830144C01 product:interferon gamma receptor, full insert sequence.
AK150503 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830008L07 product:interferon gamma receptor, full insert sequence.
AK152085 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830047F15 product:interferon gamma receptor, full insert sequence.
AK152384 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830067J08 product:interferon gamma receptor, full insert sequence.
AK153084 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830121P05 product:interferon gamma receptor, full insert sequence.
BC132599 - Mus musculus interferon gamma receptor 1, mRNA (cDNA clone MGC:164230 IMAGE:40130876), complete cds.
BC138617 - Mus musculus interferon gamma receptor 1, mRNA (cDNA clone MGC:170242 IMAGE:8861637), complete cds.
M25764 - Mouse interferon-gamma receptor mRNA, complete cds.
AK159660 - Mus musculus osteoclast-like cell cDNA, RIKEN full-length enriched library, clone:I420027I02 product:interferon gamma receptor, full insert sequence.
AK159839 - Mus musculus osteoclast-like cell cDNA, RIKEN full-length enriched library, clone:I420032M11 product:interferon gamma receptor, full insert sequence.
M28995 - Mouse interferon-gamma receptor mRNA, complete cds.
LF221533 - JP 2014500723-A/29036: Polycomb-Associated Non-Coding RNAs.
LF221534 - JP 2014500723-A/29037: Polycomb-Associated Non-Coding RNAs.
LF221536 - JP 2014500723-A/29039: Polycomb-Associated Non-Coding RNAs.
LF221537 - JP 2014500723-A/29040: Polycomb-Associated Non-Coding RNAs.
LF221538 - JP 2014500723-A/29041: Polycomb-Associated Non-Coding RNAs.
LF221539 - JP 2014500723-A/29042: Polycomb-Associated Non-Coding RNAs.
MA433509 - JP 2018138019-A/5435: Polycomb-Associated Non-Coding RNAs.
MA457110 - JP 2018138019-A/29036: Polycomb-Associated Non-Coding RNAs.
MA457111 - JP 2018138019-A/29037: Polycomb-Associated Non-Coding RNAs.
MA457113 - JP 2018138019-A/29039: Polycomb-Associated Non-Coding RNAs.
MA457114 - JP 2018138019-A/29040: Polycomb-Associated Non-Coding RNAs.
MA457115 - JP 2018138019-A/29041: Polycomb-Associated Non-Coding RNAs.
MA457116 - JP 2018138019-A/29042: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04060 - Cytokine-cytokine receptor interaction
mmu04380 - Osteoclast differentiation
mmu04630 - Jak-STAT signaling pathway
mmu04650 - Natural killer cell mediated cytotoxicity
mmu05140 - Leishmaniasis
mmu05142 - Chagas disease (American trypanosomiasis)
mmu05145 - Toxoplasmosis
mmu05162 - Measles

BioCarta from NCI Cancer Genome Anatomy Project
m_th1th2Pathway - Th1/Th2 Differentiation
m_ifngPathway - IFN gamma signaling pathway
m_nktPathway - Selective expression of chemokine receptors during T-cell polarization

Reactome (by CSHL, EBI, and GO)

Protein P15261 (Reactome details) participates in the following event(s):

R-MMU-873926 Interaction of IFNG with IFNGR
R-MMU-873918 Transphosphorylation of JAK1
R-MMU-877269 SOCS-1 and SOCS-3 binds to p-JAK2
R-MMU-873919 Phosphorylation of JAK2
R-MMU-873924 Phosphorylation of IFNGR1 by JAK kinases
R-MMU-873921 Binding of STAT1 to p-IFNGR1
R-MMU-873927 Release of STAT1 dimer from active receptor unit
R-MMU-873922 Phosphorylation of STAT1 by JAK kinases
R-MMU-909552 Phosphorylation of STAT1 at Ser727
R-MMU-877300 Interferon gamma signaling
R-MMU-877312 Regulation of IFNG signaling
R-MMU-913531 Interferon Signaling
R-MMU-1280215 Cytokine Signaling in Immune system
R-MMU-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: Ifngr, INGR1_MOUSE, NM_010511, P15261, Q91Y85, uc007eng.1, uc007eng.2
UCSC ID: uc007eng.2
RefSeq Accession: NM_010511
Protein: P15261 (aka INGR1_MOUSE or INGR_MOUSE)
CCDS: CCDS35856.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.