Mouse Gene Ifngr2 (ENSMUST00000023687.8)
  Description: Mus musculus interferon gamma receptor 2 (Ifngr2), mRNA. (from RefSeq NM_008338)
Gencode Transcript: ENSMUST00000023687.8
Gencode Gene: ENSMUSG00000022965.8
Transcript (Including UTRs)
   Position: mm10 chr16:91,547,072-91,565,623 Size: 18,552 Total Exon Count: 7 Strand: +
Coding Region
   Position: mm10 chr16:91,547,163-91,563,005 Size: 15,843 Coding Exon Count: 7 

Page IndexSequence and LinksCTDRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:91,547,072-91,565,623)mRNA (may differ from genome)Protein (332 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeStanford SOURCEUniProtKB

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -53.0091-0.582 Picture PostScript Text
3' UTR -878.802618-0.336 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003961 - Fibronectin_type3
IPR013783 - Ig-like_fold
IPR015373 - Interferon_alpha/beta_rcpt_bsu

Pfam Domains:
PF00041 - Fibronectin type III domain
PF01108 - Tissue factor
PF09294 - Interferon-alpha/beta receptor, fibronectin type III

SCOP Domains:
49265 - Fibronectin type III

ModBase Predicted Comparative 3D Structure on Q63953
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004920 interleukin-10 receptor activity

Biological Process:
GO:0019221 cytokine-mediated signaling pathway
GO:0051607 defense response to virus

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK137165 - Mus musculus adult male urinary bladder cDNA, RIKEN full-length enriched library, clone:9530021L18 product:interferon gamma receptor 2, full insert sequence.
AK169907 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630003K14 product:interferon gamma receptor 2, full insert sequence.
AK165193 - Mus musculus 12 days embryo whole body cDNA, RIKEN full-length enriched library, clone:E970028C08 product:interferon gamma receptor 2, full insert sequence.
AK143214 - Mus musculus 0 day neonate eyeball cDNA, RIKEN full-length enriched library, clone:E130310M05 product:interferon gamma receptor 2, full insert sequence.
AK086929 - Mus musculus 0 day neonate lung cDNA, RIKEN full-length enriched library, clone:E030012L02 product:interferon gamma receptor 2, full insert sequence.
AK146995 - Mus musculus 17 days embryo heart cDNA, RIKEN full-length enriched library, clone:I920083P19 product:interferon gamma receptor 2, full insert sequence.
S69336 - interferon gamma receptor beta subunit=type I transmembrane protein/IFN-gamma R species-specific cofactor [mice, early B cell line Y16, mRNA, 1283 nt].
AK087158 - Mus musculus 0 day neonate lung cDNA, RIKEN full-length enriched library, clone:E030030H21 product:interferon gamma receptor 2, full insert sequence.
BC055745 - Mus musculus interferon gamma receptor 2, mRNA (cDNA clone MGC:67077 IMAGE:6403454), complete cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04060 - Cytokine-cytokine receptor interaction
mmu04380 - Osteoclast differentiation
mmu04630 - Jak-STAT signaling pathway
mmu04650 - Natural killer cell mediated cytotoxicity
mmu05140 - Leishmaniasis
mmu05142 - Chagas disease (American trypanosomiasis)
mmu05145 - Toxoplasmosis
mmu05162 - Measles

BioCarta from NCI Cancer Genome Anatomy Project
m_th1th2Pathway - Th1/Th2 Differentiation
m_nktPathway - Selective expression of chemokine receptors during T-cell polarization
m_ifngPathway - IFN gamma signaling pathway

Reactome (by CSHL, EBI, and GO)

Protein Q63953 (Reactome details) participates in the following event(s):

R-MMU-873926 Interaction of IFNG with IFNGR
R-MMU-873918 Transphosphorylation of JAK1
R-MMU-877269 SOCS-1 and SOCS-3 binds to p-JAK2
R-MMU-873919 Phosphorylation of JAK2
R-MMU-873924 Phosphorylation of IFNGR1 by JAK kinases
R-MMU-873921 Binding of STAT1 to p-IFNGR1
R-MMU-873927 Release of STAT1 dimer from active receptor unit
R-MMU-873922 Phosphorylation of STAT1 by JAK kinases
R-MMU-909552 Phosphorylation of STAT1 at Ser727
R-MMU-877300 Interferon gamma signaling
R-MMU-877312 Regulation of IFNG signaling
R-MMU-913531 Interferon Signaling
R-MMU-1280215 Cytokine Signaling in Immune system
R-MMU-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: mCG_11456, NM_008338, Q63953, Q63953_MOUSE, uc007zxq.1, uc007zxq.2
UCSC ID: uc007zxq.2
RefSeq Accession: NM_008338
Protein: Q63953 CCDS: CCDS28327.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.