Mouse Gene C2 (ENSMUST00000025230.14) Description and Page Index
  Description: Mus musculus complement component 2 (within H-2S) (C2), mRNA. (from RefSeq NM_013484)
RefSeq Summary (NM_013484): This gene encodes component C2 of the classical pathway of the complement system. The encoded protein undergoes proteolytic processing mediated by component C1 resulting in C2a and C2b fragments. C2a fragment, in turn, selectively cleaves components C3 and C5 of the complement system. Mice lacking the encoded protein are found to be more susceptible to bacterial infections. Mutations in the human homolog of this gene are associated with disorders such as systemic lupus erythematosus, Henoch-Schonlein purpura, or polymyositis. [provided by RefSeq, Mar 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146812.1, BC011086.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END##
Gencode Transcript: ENSMUST00000025230.14
Gencode Gene: ENSMUSG00000024371.14
Transcript (Including UTRs)
   Position: mm10 chr17:34,862,605-34,882,100 Size: 19,496 Total Exon Count: 18 Strand: -
Coding Region
   Position: mm10 chr17:34,862,858-34,881,995 Size: 19,138 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:34,862,605-34,882,100)mRNA (may differ from genome)Protein (760 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: CO2_MOUSE
DESCRIPTION: RecName: Full=Complement C2; EC=3.4.21.43; AltName: Full=C3/C5 convertase; Contains: RecName: Full=Complement C2b fragment; Contains: RecName: Full=Complement C2a fragment; Flags: Precursor;
FUNCTION: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor 4b to generate the C3 or C5 convertase.
CATALYTIC ACTIVITY: Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b.
SUBCELLULAR LOCATION: Secreted.
MISCELLANEOUS: C2 is a major histocompatibility complex class-III protein.
SIMILARITY: Belongs to the peptidase S1 family.
SIMILARITY: Contains 1 peptidase S1 domain.
SIMILARITY: Contains 3 Sushi (CCP/SCR) domains.
SIMILARITY: Contains 1 VWFA domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.10105-0.306 Picture PostScript Text
3' UTR -60.40253-0.239 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011360 - Compl_C2_B
IPR016060 - Complement_control_module
IPR009003 - Pept_cys/ser_Trypsin-like
IPR018114 - Peptidase_S1/S6_AS
IPR001254 - Peptidase_S1_S6
IPR001314 - Peptidase_S1A
IPR000436 - Sushi_SCR_CCP
IPR002035 - VWF_A

Pfam Domains:
PF00084 - Sushi repeat (SCR repeat)
PF00089 - Trypsin
PF00092 - von Willebrand factor type A domain
PF13519 - von Willebrand factor type A domain

SCOP Domains:
140693 - IpaD-like
50494 - Trypsin-like serine proteases
53300 - vWA-like
57535 - Complement control module/SCR domain
111418 - Hormone receptor domain

ModBase Predicted Comparative 3D Structure on P21180
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
      
      
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004252 serine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

Biological Process:
GO:0002376 immune system process
GO:0006508 proteolysis
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0007584 response to nutrient
GO:0045087 innate immune response
GO:2000427 positive regulation of apoptotic cell clearance

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  M57891 - Mouse complement component C2 mRNA, complete cds.
BC011086 - Mus musculus complement component 2 (within H-2S), mRNA (cDNA clone MGC:18582 IMAGE:3992881), complete cds.
AK146812 - Mus musculus 17 days pregnant adult female amnion cDNA, RIKEN full-length enriched library, clone:I920060I06 product:complement component 2 (within H-2S), full insert sequence.
AK194054 - Mus musculus cDNA, clone:Y1G0114C20, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025230, based on BLAT search.
AK211697 - Mus musculus cDNA, clone:Y2G0122J05, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025230, based on BLAT search.
AK208824 - Mus musculus cDNA, clone:Y2G0112N22, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025230, based on BLAT search.
AK218673 - Mus musculus cDNA, clone:Y2G0145P03, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025230, based on BLAT search.
AK194662 - Mus musculus cDNA, clone:Y1G0116B06, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025230, based on BLAT search.
AK203677 - Mus musculus cDNA, clone:Y1G0145M08, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025230, based on BLAT search.
AK203686 - Mus musculus cDNA, clone:Y1G0145M19, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025230, based on BLAT search.
M16271 - Mouse MHC class III H2-C2 complement component mRNA (H-2-d), partial cds.
AK213705 - Mus musculus cDNA, clone:Y2G0129D12, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025230, based on BLAT search.
AK206586 - Mus musculus cDNA, clone:Y2G0105F06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025230, based on BLAT search.
AK207402 - Mus musculus cDNA, clone:Y2G0107O06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025230, based on BLAT search.
AK190654 - Mus musculus cDNA, clone:Y1G0103G14, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025230, based on BLAT search.
AK213720 - Mus musculus cDNA, clone:Y2G0129E07, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025230, based on BLAT search.
AK201085 - Mus musculus cDNA, clone:Y1G0136P06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025230, based on BLAT search.
AK216863 - Mus musculus cDNA, clone:Y2G0139M16, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025230, based on BLAT search.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04610 - Complement and coagulation cascades
mmu05150 - Staphylococcus aureus infection
mmu05322 - Systemic lupus erythematosus

Reactome (by CSHL, EBI, and GO)

Protein P21180 (Reactome details) participates in the following event(s):

R-MMU-166792 Conversion of C2 into C2a and C2b
R-MMU-166795 Formation of Classical C3 convertase (C4b:C2a complex)
R-MMU-977619 CD55 (DAF) promotes C3bBb/C4bC2a dissociation
R-MMU-977629 Displacement of C2a/Bb by CR1
R-MMU-981621 C3 convertases spontaneously dissociate
R-MMU-173636 Formation of classic pathway C5 convertase
R-MMU-977375 CR1 binds C3bBb/C4bC2a
R-MMU-981535 CD55 (DAF) binds C3bBb, C4bC2a
R-MMU-166817 Cleavage of C3 by C3 convertases
R-MMU-173680 Activation of C5
R-MMU-166663 Initial triggering of complement
R-MMU-977606 Regulation of Complement cascade
R-MMU-166658 Complement cascade
R-MMU-174577 Activation of C3 and C5
R-MMU-168249 Innate Immune System
R-MMU-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: CO2_MOUSE, NM_013484, O70350, P21180, uc008cdz.1, uc008cdz.2, uc008cdz.3
UCSC ID: uc008cdz.3
RefSeq Accession: NM_013484
Protein: P21180 (aka CO2_MOUSE)
CCDS: CCDS28664.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.