Mouse Gene Apom (ENSMUST00000025249.6) Description and Page Index
  Description: Mus musculus apolipoprotein M (Apom), mRNA. (from RefSeq NM_018816)
Gencode Transcript: ENSMUST00000025249.6
Gencode Gene: ENSMUSG00000024391.7
Transcript (Including UTRs)
   Position: mm10 chr17:35,128,997-35,132,050 Size: 3,054 Total Exon Count: 6 Strand: -
Coding Region
   Position: mm10 chr17:35,129,110-35,131,723 Size: 2,614 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:35,128,997-35,132,050)mRNA (may differ from genome)Protein (190 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: APOM_MOUSE
DESCRIPTION: RecName: Full=Apolipoprotein M; Short=Apo-M; Short=ApoM;
FUNCTION: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid (By similarity).
SUBCELLULAR LOCATION: Secreted (Potential).
TISSUE SPECIFICITY: Expressed by the liver; secreted in plasma.
SIMILARITY: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -96.50327-0.295 Picture PostScript Text
3' UTR -25.20113-0.223 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022734 - ApoM
IPR012674 - Calycin
IPR011038 - Calycin-like

Pfam Domains:
PF11032 - ApoM domain

SCOP Domains:
50814 - Lipocalins

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2XKL
- X-ray


ModBase Predicted Comparative 3D Structure on Q9Z1R3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
      
      
 RGDEnsembl   
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005319 lipid transporter activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0016209 antioxidant activity

Biological Process:
GO:0006869 lipid transport
GO:0009749 response to glucose
GO:0033344 cholesterol efflux
GO:0034375 high-density lipoprotein particle remodeling
GO:0034380 high-density lipoprotein particle assembly
GO:0034384 high-density lipoprotein particle clearance
GO:0034445 negative regulation of plasma lipoprotein particle oxidation
GO:0042157 lipoprotein metabolic process
GO:0043691 reverse cholesterol transport
GO:0098869 cellular oxidant detoxification

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0034361 very-low-density lipoprotein particle
GO:0034362 low-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0034365 discoidal high-density lipoprotein particle
GO:0034366 spherical high-density lipoprotein particle


-  Descriptions from all associated GenBank mRNAs
  AF207820 - Mus musculus apolipoprotein M mRNA, complete cds.
BC021597 - Mus musculus apolipoprotein M, mRNA (cDNA clone MGC:35948 IMAGE:5100655), complete cds.
AK004530 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1190010O19 product:apolipoprotein M, full insert sequence.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9Z1R3 (Reactome details) participates in the following event(s):

R-MMU-5246478 APOM binds retinoids
R-MMU-975634 Retinoid metabolism and transport
R-MMU-2187338 Visual phototransduction
R-MMU-6806667 Metabolism of fat-soluble vitamins
R-MMU-418594 G alpha (i) signalling events
R-MMU-196854 Metabolism of vitamins and cofactors
R-MMU-388396 GPCR downstream signalling
R-MMU-1430728 Metabolism
R-MMU-372790 Signaling by GPCR
R-MMU-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: APOM_MOUSE, Ng20, NM_018816, Q9Z1R3, uc008cga.1, uc008cga.2
UCSC ID: uc008cga.2
RefSeq Accession: NM_018816
Protein: Q9Z1R3 (aka APOM_MOUSE)
CCDS: CCDS28687.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.