ID:I22R2_MOUSE DESCRIPTION: RecName: Full=Interleukin-22 receptor subunit alpha-2; Short=IL-22 receptor subunit alpha-2; Short=IL-22R-alpha-2; Short=IL-22RA2; AltName: Full=Cytokine receptor family type 2, soluble 1; Short=CRF2-S1; AltName: Full=Interleukin-22-binding protein; Short=IL-22BP; Short=IL22BP; AltName: Full=ZcytoR16; Flags: Precursor; FUNCTION: Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Highly expressed in lymph nodes and at lower levels in lung, spleen, and thymus. Not expressed in kidney, liver and heart. SIMILARITY: Belongs to the type II cytokine receptor family. SIMILARITY: Contains 2 fibronectin type-III domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q80XF5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.