Mouse Gene Il22ra2 (ENSMUST00000036564.7)
  Description: Mus musculus interleukin 22 receptor, alpha 2 (Il22ra2), mRNA. (from RefSeq NM_178258)
Gencode Transcript: ENSMUST00000036564.7
Gencode Gene: ENSMUSG00000039760.8
Transcript (Including UTRs)
   Position: mm10 chr10:19,621,998-19,634,681 Size: 12,684 Total Exon Count: 5 Strand: +
Coding Region
   Position: mm10 chr10:19,622,040-19,632,918 Size: 10,879 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:19,621,998-19,634,681)mRNA (may differ from genome)Protein (230 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
ReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: I22R2_MOUSE
DESCRIPTION: RecName: Full=Interleukin-22 receptor subunit alpha-2; Short=IL-22 receptor subunit alpha-2; Short=IL-22R-alpha-2; Short=IL-22RA2; AltName: Full=Cytokine receptor family type 2, soluble 1; Short=CRF2-S1; AltName: Full=Interleukin-22-binding protein; Short=IL-22BP; Short=IL22BP; AltName: Full=ZcytoR16; Flags: Precursor;
FUNCTION: Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Highly expressed in lymph nodes and at lower levels in lung, spleen, and thymus. Not expressed in kidney, liver and heart.
SIMILARITY: Belongs to the type II cytokine receptor family.
SIMILARITY: Contains 2 fibronectin type-III domains.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.5042-0.179 Picture PostScript Text
3' UTR -418.901763-0.238 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003961 - Fibronectin_type3
IPR013783 - Ig-like_fold
IPR015373 - Interferon_alpha/beta_rcpt_bsu

Pfam Domains:
PF01108 - Tissue factor
PF09294 - Interferon-alpha/beta receptor, fibronectin type III

SCOP Domains:
49265 - Fibronectin type III

ModBase Predicted Comparative 3D Structure on Q80XF5
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0042017 interleukin-22 binding
GO:0042018 interleukin-22 receptor activity

Biological Process:
GO:0019221 cytokine-mediated signaling pathway
GO:0042509 regulation of tyrosine phosphorylation of STAT protein
GO:0050728 negative regulation of inflammatory response

Cellular Component:
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK139024 - Mus musculus adult male aorta and vein cDNA, RIKEN full-length enriched library, clone:A530082J17 product:interleukin 22 receptor, alpha 2, full insert sequence.
AK040641 - Mus musculus adult male aorta and vein cDNA, RIKEN full-length enriched library, clone:A530002E19 product:interleukin 22 receptor, alpha 2, full insert sequence.
AK138913 - Mus musculus adult male aorta and vein cDNA, RIKEN full-length enriched library, clone:A530001K23 product:interleukin 22 receptor, alpha 2, full insert sequence.
BC126872 - Mus musculus interleukin 22 receptor, alpha 2, mRNA (cDNA clone MGC:123920 IMAGE:40044756), complete cds.
AJ555484 - Mus musculus mRNA for putative cytokine receptor family II soluble 1 precursor (CRF2-s1 gene).
BC124998 - Mus musculus interleukin 22 receptor, alpha 2, mRNA (cDNA clone MGC:123915 IMAGE:40044741), complete cds.
AF493604 - Mus musculus interleukin 22 soluble receptor mRNA, complete cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04060 - Cytokine-cytokine receptor interaction
mmu04630 - Jak-STAT signaling pathway

Reactome (by CSHL, EBI, and GO)

Protein Q80XF5 (Reactome details) participates in the following event(s):

R-MMU-448741 IL22RA2 binds IL22
R-MMU-8854691 Interleukin-20 family signaling
R-MMU-449147 Signaling by Interleukins
R-MMU-1280215 Cytokine Signaling in Immune system
R-MMU-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: I22R2_MOUSE, NM_178258, Q3UU14, Q7TNI5, Q80XF5, uc007enh.1, uc007enh.2
UCSC ID: uc007enh.2
RefSeq Accession: NM_178258
Protein: Q80XF5 (aka I22R2_MOUSE)
CCDS: CCDS23717.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.