Mouse Gene Grid1 (ENSMUST00000043349.6) Description and Page Index
  Description: Mus musculus glutamate receptor, ionotropic, delta 1 (Grid1), mRNA. (from RefSeq NM_008166)
Gencode Transcript: ENSMUST00000043349.6
Gencode Gene: ENSMUSG00000041078.7
Transcript (Including UTRs)
   Position: mm10 chr14:34,820,108-35,583,379 Size: 763,272 Total Exon Count: 16 Strand: +
Coding Region
   Position: mm10 chr14:34,820,228-35,580,809 Size: 760,582 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:34,820,108-35,583,379)mRNA (may differ from genome)Protein (1009 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: GRID1_MOUSE
DESCRIPTION: RecName: Full=Glutamate receptor delta-1 subunit; Short=GluR delta-1 subunit; Flags: Precursor;
FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity).
TISSUE SPECIFICITY: Equally in forebrain and cerebellum.
SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID1 subfamily.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -69.90120-0.583 Picture PostScript Text
3' UTR -759.882570-0.296 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001828 - ANF_lig-bd_rcpt
IPR019594 - Glu_rcpt_Glu/Gly-bd
IPR001320 - Iontro_glu_rcpt
IPR001508 - NMDA_rcpt
IPR001638 - SBP_bac_3

Pfam Domains:
PF00060 - Ligand-gated ion channel
PF00497 - Bacterial extracellular solute-binding proteins, family 3
PF01094 - Receptor family ligand binding region
PF10613 - Ligated ion channel L-glutamate- and glycine-binding site

SCOP Domains:
53822 - Periplasmic binding protein-like I
53850 - Periplasmic binding protein-like II

ModBase Predicted Comparative 3D Structure on Q61627
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004970 ionotropic glutamate receptor activity
GO:0005216 ion channel activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005515 protein binding
GO:0038023 signaling receptor activity

Biological Process:
GO:0006811 ion transport
GO:0007165 signal transduction
GO:0034220 ion transmembrane transport
GO:0035176 social behavior
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0060079 excitatory postsynaptic potential

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0045202 synapse
GO:0045211 postsynaptic membrane


-  Descriptions from all associated GenBank mRNAs
  AK138279 - Mus musculus adult male hypothalamus cDNA, RIKEN full-length enriched library, clone:A230054J23 product:glutamate receptor, ionotropic, delta 1, full insert sequence.
D10171 - Mus musculus mRNA for glutamate receptor channel subunit delta 1, complete cds.
BC167177 - Synthetic construct Mus musculus clone IMAGE:100068077, MGC:195694 glutamate receptor, ionotropic, delta 1 (Grid1) mRNA, encodes complete protein.
AK039103 - Mus musculus adult male hypothalamus cDNA, RIKEN full-length enriched library, clone:A230096K23 product:39 KDA ANTIGEN homolog [Leishmania donovani], full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04080 - Neuroactive ligand-receptor interaction

-  Other Names for This Gene
  Alternate Gene Symbols: GRID1_MOUSE, NM_008166, Q3UUL5, Q61627, uc007tbj.1, uc007tbj.2
UCSC ID: uc007tbj.2
RefSeq Accession: NM_008166
Protein: Q61627 (aka GRID1_MOUSE or GRD1_MOUSE)
CCDS: CCDS26944.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.