Mouse Gene Nfkbid (ENSMUST00000046177.9) from GENCODE VM30
  Description: Mus musculus nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta (Nfkbid), transcript variant 3, mRNA. (from RefSeq NM_172142)
Gencode Transcript: ENSMUST00000046177.9
Gencode Gene: ENSMUSG00000036931.16
Transcript (Including UTRs)
   Position: mm39 chr7:30,122,700-30,128,171 Size: 5,472 Total Exon Count: 11 Strand: +
Coding Region
   Position: mm39 chr7:30,123,871-30,127,612 Size: 3,742 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2022-06-02 09:33:23

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr7:30,122,700-30,128,171)mRNA (may differ from genome)Protein (327 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
Entrez GeneExonPrimerGeneCardsMGIPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=NF-kappa-B inhibitor delta; AltName: Full=I-kappa-B-delta; Short=IkB-delta; Short=IkappaBdelta; AltName: Full=IkappaBNS;
FUNCTION: May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. According to PubMed:11931770, it may also regulate TCR-induced negative selection of thymocytes.
SUBUNIT: Interacts with NFKB1, RELA and RELB; in the nucleus.
TISSUE SPECIFICITY: Specifically expressed in spleen and at low levels in thymus. Expressed in a population of antigen-presenting dendritic cells which may act as regulators of systemic inflammatory response.
INDUCTION: Up-regulated in thymocytes upon TCR-triggered cell death (at protein level). Up-regulated by IL-10 or LPS.
DISRUPTION PHENOTYPE: Mice are highly sensitive to LPS-induced endotoxin shock and susceptible to intestinal inflammation caused by exposure to microflora. They display no overt T-cell selection phenotype but an impaired proliferation of T-cells. Thymocytes and T-cells seem to produce less IL-2 and IFNG.
SIMILARITY: Belongs to the NF-kappa-B inhibitor family.
SIMILARITY: Contains 6 ANK repeats.
SEQUENCE CAUTION: Sequence=BAE39455.1; Type=Frameshift; Positions=306;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -170.00496-0.343 Picture PostScript Text
3' UTR -177.70559-0.318 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom

Pfam Domains:
PF12796 - Ankyrin repeats (3 copies)

ModBase Predicted Comparative 3D Structure on Q2TB02
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003712 transcription cofactor activity
GO:0005515 protein binding
GO:0051059 NF-kappaB binding

Biological Process:
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006954 inflammatory response
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0033085 negative regulation of T cell differentiation in thymus
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050852 T cell receptor signaling pathway
GO:0070245 positive regulation of thymocyte apoptotic process
GO:2000321 positive regulation of T-helper 17 cell differentiation

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  LF196190 - JP 2014500723-A/3693: Polycomb-Associated Non-Coding RNAs.
MA431767 - JP 2018138019-A/3693: Polycomb-Associated Non-Coding RNAs.
AK155969 - Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830002J06 product:IkappaBNS, full insert sequence.
AK167356 - Mus musculus 14 days pregnant adult female placenta cDNA, RIKEN full-length enriched library, clone:I530008F09 product:IkappaBNS, full insert sequence.
LF291923 - JP 2014500723-A/99426: Polycomb-Associated Non-Coding RNAs.
MA527500 - JP 2018138019-A/99426: Polycomb-Associated Non-Coding RNAs.
AY078069 - Mus musculus IkappaBNS mRNA, complete cds.
BC110633 - Mus musculus nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta, mRNA (cDNA clone MGC:130396 IMAGE:40058047), complete cds.
LF291927 - JP 2014500723-A/99430: Polycomb-Associated Non-Coding RNAs.
MA527504 - JP 2018138019-A/99430: Polycomb-Associated Non-Coding RNAs.
LF291928 - JP 2014500723-A/99431: Polycomb-Associated Non-Coding RNAs.
MA527505 - JP 2018138019-A/99431: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENSMUST00000046177.1, ENSMUST00000046177.2, ENSMUST00000046177.3, ENSMUST00000046177.4, ENSMUST00000046177.5, ENSMUST00000046177.6, ENSMUST00000046177.7, ENSMUST00000046177.8, IKBD_MOUSE, Ikbns, NM_172142, Q2TB02, Q3TJP0, Q8CIW1, uc009gej.1, uc009gej.2, uc009gej.3
UCSC ID: ENSMUST00000046177.9
RefSeq Accession: NM_172142
Protein: Q2TB02 (aka IKBD_MOUSE)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.