Mouse Gene Ddc (ENSMUST00000066237.9) Description and Page Index
  Description: Pyridoxal phosphate (By similarity). (from UniProt Q5SUV8)
Gencode Transcript: ENSMUST00000066237.9
Gencode Gene: ENSMUSG00000020182.16
Transcript (Including UTRs)
   Position: mm10 chr11:11,814,101-11,898,044 Size: 83,944 Total Exon Count: 15 Strand: -
Coding Region
   Position: mm10 chr11:11,815,228-11,880,642 Size: 65,415 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:11,814,101-11,898,044)mRNA (may differ from genome)Protein (480 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Dopa decarboxylase;
COFACTOR: Pyridoxal phosphate (By similarity).
SIMILARITY: Belongs to the group II decarboxylase family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -3.5045-0.078 Picture PostScript Text
3' UTR -98.10434-0.226 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010977 - Aromatic_deC
IPR002129 - PyrdxlP-dep_de-COase
IPR015424 - PyrdxlP-dep_Trfase_major_dom
IPR015421 - PyrdxlP-dep_Trfase_major_sub1
IPR015422 - PyrdxlP-dep_Trfase_major_sub2
IPR021115 - Pyridoxal-P_BS

Pfam Domains:
PF00282 - Pyridoxal-dependent decarboxylase conserved domain
PF01212 - Beta-eliminating lyase

SCOP Domains:
53383 - PLP-dependent transferases

ModBase Predicted Comparative 3D Structure on Q5SUV8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003824 catalytic activity
GO:0004058 aromatic-L-amino-acid decarboxylase activity
GO:0016597 amino acid binding
GO:0016829 lyase activity
GO:0016831 carboxy-lyase activity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0030170 pyridoxal phosphate binding
GO:0036468 L-dopa decarboxylase activity

Biological Process:
GO:0006520 cellular amino acid metabolic process
GO:0007623 circadian rhythm
GO:0009636 response to toxic substance
GO:0010259 multicellular organism aging
GO:0015842 aminergic neurotransmitter loading into synaptic vesicle
GO:0019752 carboxylic acid metabolic process
GO:0033076 isoquinoline alkaloid metabolic process
GO:0035690 cellular response to drug
GO:0042416 dopamine biosynthetic process
GO:0042427 serotonin biosynthetic process
GO:0046684 response to pyrethroid
GO:0052314 phytoalexin metabolic process
GO:0071312 cellular response to alkaloid
GO:0071363 cellular response to growth factor stimulus

Cellular Component:
GO:0005737 cytoplasm
GO:0008021 synaptic vesicle
GO:0030424 axon
GO:0043025 neuronal cell body

-  Descriptions from all associated GenBank mRNAs
  LF192535 - JP 2014500723-A/38: Polycomb-Associated Non-Coding RNAs.
BC089594 - Mus musculus cDNA clone IMAGE:6745988, containing frame-shift errors.
AK050963 - Mus musculus 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030046H13 product:dopa decarboxylase, full insert sequence.
AK149141 - Mus musculus 2 days neonate sympathetic ganglion cDNA, RIKEN full-length enriched library, clone:7120488C16 product:dopa decarboxylase, full insert sequence.
BC060989 - Mus musculus cDNA clone IMAGE:30310870, containing frame-shift errors.
AF071068 - Mus musculus aromatic-L-amino-acid decarboxylase mRNA, complete cds.
BC152724 - Synthetic construct Mus musculus clone IMAGE:100015961, MGC:184342 dopa decarboxylase (Ddc) mRNA, encodes complete protein.
AK011834 - Mus musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610109O21 product:dopa decarboxylase, full insert sequence.
AF012882 - Mus musculus aromatic L-amino acid decarboxylase mRNA, partial cds.
AF012881 - Mus musculus aromatic L-amino acid decarboxylase mRNA, partial cds.
AK160769 - Mus musculus 13 days embryo head cDNA, RIKEN full-length enriched library, clone:3110085H16 product:dopa decarboxylase, full insert sequence.
MA428112 - JP 2018138019-A/38: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu00340 - Histidine metabolism
mmu00350 - Tyrosine metabolism
mmu00360 - Phenylalanine metabolism
mmu00380 - Tryptophan metabolism
mmu01100 - Metabolic pathways

-  Other Names for This Gene
  Alternate Gene Symbols: BC089594, Q5SUV8, Q5SUV8_MOUSE, RP23-373H2.3-001, uc287wqu.1
UCSC ID: uc287wqu.1
RefSeq Accession: NM_001190448
Protein: Q5SUV8 CCDS: CCDS24439.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.