Mouse Gene Ddc (ENSMUST00000066237.9) Description and Page Index
Description: Pyridoxal phosphate (By similarity). (from UniProt Q5SUV8)
Gencode Transcript: ENSMUST00000066237.9
Gencode Gene: ENSMUSG00000020182.16
Transcript (Including UTRs)
Position: mm10 chr11:11,814,101-11,898,044 Size: 83,944 Total Exon Count: 15 Strand: -
Position: mm10 chr11:11,815,228-11,880,642 Size: 65,415 Coding Exon Count: 13
Data last updated: 2019-09-19
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Dopa decarboxylase;
COFACTOR: Pyridoxal phosphate (By similarity). SIMILARITY: Belongs to the group II decarboxylase family.
Comparative Toxicogenomics Database (CTD)
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR010977 - Aromatic_deC
IPR002129 - PyrdxlP-dep_de-COase
IPR015424 - PyrdxlP-dep_Trfase_major_dom
IPR015421 - PyrdxlP-dep_Trfase_major_sub1
IPR015422 - PyrdxlP-dep_Trfase_major_sub2
IPR021115 - Pyridoxal-P_BS
Pfam Domains: PF00282 - Pyridoxal-dependent decarboxylase conserved domain
PF01212 - Beta-eliminating lyase
SCOP Domains: 53383 - PLP-dependent transferases
ModBase Predicted Comparative 3D Structure on Q5SUV8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF192535 - JP 2014500723-A/38: Polycomb-Associated Non-Coding RNAs. BC089594 - Mus musculus cDNA clone IMAGE:6745988, containing frame-shift errors. AK050963 - Mus musculus 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030046H13 product:dopa decarboxylase, full insert sequence. AK149141 - Mus musculus 2 days neonate sympathetic ganglion cDNA, RIKEN full-length enriched library, clone:7120488C16 product:dopa decarboxylase, full insert sequence. BC060989 - Mus musculus cDNA clone IMAGE:30310870, containing frame-shift errors. AF071068 - Mus musculus aromatic-L-amino-acid decarboxylase mRNA, complete cds. BC152724 - Synthetic construct Mus musculus clone IMAGE:100015961, MGC:184342 dopa decarboxylase (Ddc) mRNA, encodes complete protein. AK011834 - Mus musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610109O21 product:dopa decarboxylase, full insert sequence. AF012882 - Mus musculus aromatic L-amino acid decarboxylase mRNA, partial cds. AF012881 - Mus musculus aromatic L-amino acid decarboxylase mRNA, partial cds. AK160769 - Mus musculus 13 days embryo head cDNA, RIKEN full-length enriched library, clone:3110085H16 product:dopa decarboxylase, full insert sequence. MA428112 - JP 2018138019-A/38: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu00340 - Histidine metabolism mmu00350 - Tyrosine metabolism mmu00360 - Phenylalanine metabolism mmu00380 - Tryptophan metabolism mmu01100 - Metabolic pathways
Other Names for This Gene
Alternate Gene Symbols: BC089594, Q5SUV8, Q5SUV8_MOUSE, RP23-373H2.3-001, uc287wqu.1 UCSC ID: uc287wqu.1 RefSeq Accession: NM_001190448
Q5SUV8 CCDS: CCDS24439.1
Gene Model Information
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.