Mouse Gene Spink7 (ENSMUST00000076194.5) Description and Page Index
  Description: Mus musculus serine peptidase inhibitor, Kazal type 7 (putative) (Spink7), mRNA. (from RefSeq NM_001001803)
Gencode Transcript: ENSMUST00000076194.5
Gencode Gene: ENSMUSG00000060201.5
Transcript (Including UTRs)
   Position: mm10 chr18:62,592,194-62,596,327 Size: 4,134 Total Exon Count: 4 Strand: -
Coding Region
   Position: mm10 chr18:62,592,413-62,596,264 Size: 3,852 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr18:62,592,194-62,596,327)mRNA (may differ from genome)Protein (85 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ISK7_MOUSE
DESCRIPTION: RecName: Full=Serine protease inhibitor Kazal-type 7; AltName: Full=Esophagus cancer-related gene 2 protein; Short=ECRG-2; Flags: Precursor;
FUNCTION: Probable serine protease inhibitor.
SUBCELLULAR LOCATION: Secreted (Potential).
SIMILARITY: Contains 1 Kazal-like domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.5063-0.151 Picture PostScript Text
3' UTR -49.60219-0.226 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011497 - Kazal-type_dom
IPR002350 - Prot_inh_Kazal

Pfam Domains:
PF00050 - Kazal-type serine protease inhibitor domain
PF07648 - Kazal-type serine protease inhibitor domain

SCOP Domains:
100895 - Kazal-type serine protease inhibitors

ModBase Predicted Comparative 3D Structure on Q6IE32
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
      
      
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity

Biological Process:
GO:0010466 negative regulation of peptidase activity
GO:0060046 regulation of acrosome reaction
GO:1900004 negative regulation of serine-type endopeptidase activity

Cellular Component:
GO:0001669 acrosomal vesicle
GO:0005576 extracellular region
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  BC148575 - Synthetic construct Mus musculus clone IMAGE:100015514, MGC:183335 serine peptidase inhibitor, Kazal type 7 (putative) (Spink7) mRNA, encodes complete protein.
BC156750 - Synthetic construct Mus musculus clone IMAGE:100062262, MGC:190438 serine peptidase inhibitor, Kazal type 7 (putative) (Spink7) mRNA, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: Ecg2, ISK7_MOUSE, NM_001001803, Q6IE32, uc012bdx.1, uc012bdx.2
UCSC ID: uc012bdx.2
RefSeq Accession: NM_001001803
Protein: Q6IE32 (aka ISK7_MOUSE)
CCDS: CCDS50304.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.