Mouse Gene Arhgap12 (ENSMUST00000077128.12) Description and Page Index
  Description: Mus musculus Rho GTPase activating protein 12 (Arhgap12), transcript variant 2, mRNA. (from RefSeq NM_029277)
Gencode Transcript: ENSMUST00000077128.12
Gencode Gene: ENSMUSG00000041225.16
Transcript (Including UTRs)
   Position: mm10 chr18:6,024,785-6,135,907 Size: 111,123 Total Exon Count: 18 Strand: -
Coding Region
   Position: mm10 chr18:6,026,556-6,112,362 Size: 85,807 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr18:6,024,785-6,135,907)mRNA (may differ from genome)Protein (813 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Rho GTPase activating protein 12; SubName: Full=Rho GTPase-activating protein 12;
SIMILARITY: Contains 1 PH domain.
SIMILARITY: Contains 1 Rho-GAP domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -64.40218-0.295 Picture PostScript Text
3' UTR -460.601771-0.260 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
IPR015767 - Rho_GTPase_activating
IPR008936 - Rho_GTPase_activation_prot
IPR000198 - RhoGAP_dom
IPR001452 - SH3_domain
IPR001202 - WW_Rsp5_WWP

Pfam Domains:
PF00169 - PH domain
PF00397 - WW domain
PF00620 - RhoGAP domain
PF14604 - Variant SH3 domain
PF15410 - Pleckstrin homology domain
PF16618 - Linker region between SH3 and WW domains on ARHGAP12

SCOP Domains:
48350 - GTPase activation domain, GAP
50044 - SH3-domain
50729 - PH domain-like
51045 - WW domain

ModBase Predicted Comparative 3D Structure on B2RUJ8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005096 GTPase activator activity

Biological Process:
GO:0007165 signal transduction
GO:0043547 positive regulation of GTPase activity

-  Descriptions from all associated GenBank mRNAs
  BC037608 - Mus musculus cDNA clone IMAGE:5358025, containing frame-shift errors.
BC145506 - Mus musculus Rho GTPase activating protein 12, mRNA (cDNA clone MGC:179077 IMAGE:9054069), complete cds.
BC141184 - Mus musculus Rho GTPase activating protein 12, mRNA (cDNA clone MGC:176145 IMAGE:9055796), complete cds.
AK031648 - Mus musculus 13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030468D24 product:hypothetical Repeat in HS1/Cortactin/Pleckstrin homology (PH) domain/ WW / rsp5 / WWP domain/RhoGAP domain/Src homology 3 (SH3) domain containing protein, full insert sequence.
BC024633 - Mus musculus Rho GTPase activating protein 12, mRNA (cDNA clone IMAGE:4038635), complete cds.
AK077063 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4932701K03 product:hypothetical Repeat in HS1/Cortactin, Pleckstrin homology (PH), WW/rsp5/WWP domain, RhoGAP domain, Src homology 3 (SH3) domain containing protein, full insert sequence.
AK037784 - Mus musculus 16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130049L03 product:inferred: hypothetical protein {Macaca fascicularis}, full insert sequence.
AK012717 - Mus musculus 10, 11 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2810011M08 product:hypothetical Src homology 3 (SH3) domain profile/Repeat in HS1/Cortactin/WW/rsp5/WWP domain profile/WW / rsp5 / WWP domain/Src homology 3 (SH3) domain containing protein, full insert sequence.
AK035186 - Mus musculus 12 days embryo embryonic body between diaphragm region and neck cDNA, RIKEN full-length enriched library, clone:9430097I07 product:RIKEN cDNA 2810011M08 gene, full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RUJ8, B2RUJ8_MOUSE, NM_029277, uc008dzd.1, uc008dzd.2, uc008dzd.3
UCSC ID: uc008dzd.3
RefSeq Accession: NM_029277
Protein: B2RUJ8 CCDS: CCDS37722.1, CCDS37723.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.