Mouse Gene Ccin (ENSMUST00000095107.2) Description and Page Index
  Description: Mus musculus calicin (Ccin), mRNA. (from RefSeq NM_001002787)
Gencode Transcript: ENSMUST00000095107.2
Gencode Gene: ENSMUSG00000070999.2
Transcript (Including UTRs)
   Position: mm10 chr4:43,983,483-43,985,423 Size: 1,941 Total Exon Count: 1 Strand: +
Coding Region
   Position: mm10 chr4:43,983,595-43,985,361 Size: 1,767 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr4:43,983,483-43,985,423)mRNA (may differ from genome)Protein (588 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Calicin;
FUNCTION: Possible morphogenetic cytoskeletal element in spermiogenic differentiation (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, perinuclear theca, calyx (By similarity). Note=Sperm head cytoskeletal structure tightly associated to the nucleus (By similarity).
SIMILARITY: Contains 1 BACK (BTB/Kelch associated) domain.
SIMILARITY: Contains 1 BTB (POZ) domain.
SIMILARITY: Contains 6 Kelch repeats.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.80112-0.141 Picture PostScript Text
3' UTR -4.9062-0.079 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011705 - BACK
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR015915 - Kelch-typ_b-propeller
IPR006652 - Kelch_1

Pfam Domains:
PF00651 - BTB/POZ domain
PF01344 - Kelch motif
PF07707 - BTB And C-terminal Kelch
PF13415 - Galactose oxidase, central domain
PF13418 - Galactose oxidase, central domain
PF13964 - Kelch motif

SCOP Domains:
117281 - Kelch motif
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
82171 - DPP6 N-terminal domain-like
54695 - POZ domain

ModBase Predicted Comparative 3D Structure on Q8CDE2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding
GO:0004842 ubiquitin-protein transferase activity

Biological Process:
GO:0007275 multicellular organism development
GO:0007283 spermatogenesis
GO:0016567 protein ubiquitination
GO:0030154 cell differentiation

Cellular Component:
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0015629 actin cytoskeleton
GO:0031463 Cul3-RING ubiquitin ligase complex
GO:0033150 cytoskeletal calyx

-  Descriptions from all associated GenBank mRNAs
  AK030197 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4933417A14 product:CALICIN homolog [Bos taurus], full insert sequence.
BC150949 - Mus musculus calicin, mRNA (cDNA clone MGC:183860 IMAGE:9087860), complete cds.
BC150952 - Mus musculus calicin, mRNA (cDNA clone MGC:183863 IMAGE:9087863), complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: CALI_MOUSE, NM_001002787, Q8CDE2, uc008srg.1, uc008srg.2
UCSC ID: uc008srg.2
RefSeq Accession: NM_001002787
Protein: Q8CDE2 (aka CALI_MOUSE)
CCDS: CCDS18118.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.