Mouse Gene Nt5c3b (ENSMUST00000107399.8) Description and Page Index
  Description: Mus musculus 5'-nucleotidase, cytosolic IIIB (Nt5c3b), transcript variant 2, mRNA. (from RefSeq NM_026561)
Gencode Transcript: ENSMUST00000107399.8
Gencode Gene: ENSMUSG00000017176.17
Transcript (Including UTRs)
   Position: mm10 chr11:100,422,321-100,441,089 Size: 18,769 Total Exon Count: 9 Strand: -
Coding Region
   Position: mm10 chr11:100,422,928-100,441,055 Size: 18,128 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:100,422,321-100,441,089)mRNA (may differ from genome)Protein (261 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
ReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Cytosolic 5'-nucleotidase III-like protein; Short=cN-III-like protein; EC=;
FUNCTION: Can act both as nucleotidase and as phosphotransferase (By similarity).
CATALYTIC ACTIVITY: A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
SUBCELLULAR LOCATION: Cytoplasm (Potential).
SIMILARITY: Belongs to the pyrimidine 5'-nucleotidase family.
SEQUENCE CAUTION: Sequence=AAH15307.1; Type=Erroneous initiation; Sequence=BAB24814.1; Type=Frameshift; Positions=10; Sequence=BAC38632.1; Type=Erroneous initiation; Sequence=BAE28422.1; Type=Erroneous initiation; Sequence=BAE37053.1; Type=Erroneous initiation; Sequence=BAE38749.1; Type=Erroneous initiation; Sequence=CAM23034.1; Type=Erroneous gene model prediction; Sequence=CAM23036.1; Type=Erroneous gene model prediction;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -10.2034-0.300 Picture PostScript Text
3' UTR -205.70607-0.339 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023214 - HAD-like_dom
IPR006434 - Pyrimidine_nucleotidase_eu

Pfam Domains:
PF05822 - Pyrimidine 5'-nucleotidase (UMPH-1)

SCOP Domains:
56784 - HAD-like

ModBase Predicted Comparative 3D Structure on Q3UFY7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0003674 molecular_function
GO:0008253 5'-nucleotidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

Biological Process:
GO:0008150 biological_process
GO:0009117 nucleotide metabolic process
GO:0016311 dephosphorylation

Cellular Component:
GO:0005575 cellular_component
GO:0005737 cytoplasm

-  Descriptions from all associated GenBank mRNAs
  LF198873 - JP 2014500723-A/6376: Polycomb-Associated Non-Coding RNAs.
AK082816 - Mus musculus ES cells cDNA, RIKEN full-length enriched library, clone:C330027I04 product:SIMILAR TO HYPOTHETICAL PROTEIN MGC20781 homolog [Mus musculus], full insert sequence.
AK006972 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:1700081M10 product:hypothetical HAD-like structure containing protein, full insert sequence.
AK162770 - Mus musculus 16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130036C05 product:hypothetical HAD-superfamily subfamily IE hydrolase containing protein, full insert sequence.
AK148222 - Mus musculus B16 F10Y cells cDNA, RIKEN full-length enriched library, clone:G370058G16 product:hypothetical HAD-superfamily subfamily IE hydrolase containing protein, full insert sequence.
AK011707 - Mus musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610037D24 product:SIMILAR TO HYPOTHETICAL PROTEIN MGC20781 homolog [Mus musculus], full insert sequence.
BC015307 - Mus musculus 5'-nucleotidase, cytosolic III-like, mRNA (cDNA clone MGC:19356 IMAGE:4239117), complete cds.
AK200125 - Mus musculus cDNA, clone:Y1G0133H15, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000017320, based on BLAT search.
AK211190 - Mus musculus cDNA, clone:Y2G0120P04, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000066380, based on BLAT search.
AK166393 - Mus musculus mammary gland RCB-0527 Jyg-MC(B) cDNA, RIKEN full-length enriched library, clone:G930008G13 product:hypothetical protein, full insert sequence.
MA434450 - JP 2018138019-A/6376: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q3UFY7 (Reactome details) participates in the following event(s):

R-MMU-5694126 NT5C3B hydrolyses 7MGP to 7MG
R-MMU-429958 mRNA decay by 3' to 5' exoribonuclease
R-MMU-429914 Deadenylation-dependent mRNA decay
R-MMU-8953854 Metabolism of RNA

-  Other Names for This Gene
  Alternate Gene Symbols: 5NT3L_MOUSE, A2A4I2, A2A4I3, NM_026561, Nt5c3l, Q3TLP3, Q3UFY7, Q8BHU9, Q91WE8, Q9D9F9, uc007llc.1, uc007llc.2
UCSC ID: uc007llc.2
RefSeq Accession: NM_026561
Protein: Q3UFY7 (aka 5NT3L_MOUSE)
CCDS: CCDS48930.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.