Mouse Gene Nfkbid (ENSMUST00000108175.8) from GENCODE VM30
  Description: Mus musculus nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta (Nfkbid), transcript variant 2, mRNA. (from RefSeq NM_001360907)
Gencode Transcript: ENSMUST00000108175.8
Gencode Gene: ENSMUSG00000036931.16
Transcript (Including UTRs)
   Position: mm39 chr7:30,121,831-30,128,170 Size: 6,340 Total Exon Count: 12 Strand: +
Coding Region
   Position: mm39 chr7:30,123,871-30,127,612 Size: 3,742 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2022-06-02 09:33:23

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:30,121,831-30,128,170)mRNA (may differ from genome)Protein (327 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: IKBD_MOUSE
DESCRIPTION: RecName: Full=NF-kappa-B inhibitor delta; AltName: Full=I-kappa-B-delta; Short=IkB-delta; Short=IkappaBdelta; AltName: Full=IkappaBNS;
FUNCTION: May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. According to PubMed:11931770, it may also regulate TCR-induced negative selection of thymocytes.
SUBUNIT: Interacts with NFKB1, RELA and RELB; in the nucleus.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Specifically expressed in spleen and at low levels in thymus. Expressed in a population of antigen-presenting dendritic cells which may act as regulators of systemic inflammatory response.
INDUCTION: Up-regulated in thymocytes upon TCR-triggered cell death (at protein level). Up-regulated by IL-10 or LPS.
DISRUPTION PHENOTYPE: Mice are highly sensitive to LPS-induced endotoxin shock and susceptible to intestinal inflammation caused by exposure to microflora. They display no overt T-cell selection phenotype but an impaired proliferation of T-cells. Thymocytes and T-cells seem to produce less IL-2 and IFNG.
SIMILARITY: Belongs to the NF-kappa-B inhibitor family.
SIMILARITY: Contains 6 ANK repeats.
SEQUENCE CAUTION: Sequence=BAE39455.1; Type=Frameshift; Positions=306;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -170.80458-0.373 Picture PostScript Text
3' UTR -177.70558-0.318 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom

Pfam Domains:
PF12796 - Ankyrin repeats (3 copies)

ModBase Predicted Comparative 3D Structure on Q2TB02
FrontTopSide
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003712 transcription cofactor activity
GO:0005515 protein binding
GO:0051059 NF-kappaB binding

Biological Process:
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006954 inflammatory response
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0033085 negative regulation of T cell differentiation in thymus
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050852 T cell receptor signaling pathway
GO:0070245 positive regulation of thymocyte apoptotic process
GO:2000321 positive regulation of T-helper 17 cell differentiation

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  LF196190 - JP 2014500723-A/3693: Polycomb-Associated Non-Coding RNAs.
MA431767 - JP 2018138019-A/3693: Polycomb-Associated Non-Coding RNAs.
AK155969 - Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830002J06 product:IkappaBNS, full insert sequence.
AK167356 - Mus musculus 14 days pregnant adult female placenta cDNA, RIKEN full-length enriched library, clone:I530008F09 product:IkappaBNS, full insert sequence.
AY078069 - Mus musculus IkappaBNS mRNA, complete cds.
BC110633 - Mus musculus nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta, mRNA (cDNA clone MGC:130396 IMAGE:40058047), complete cds.
LF291927 - JP 2014500723-A/99430: Polycomb-Associated Non-Coding RNAs.
MA527504 - JP 2018138019-A/99430: Polycomb-Associated Non-Coding RNAs.
LF291928 - JP 2014500723-A/99431: Polycomb-Associated Non-Coding RNAs.
MA527505 - JP 2018138019-A/99431: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENSMUST00000108175.1, ENSMUST00000108175.2, ENSMUST00000108175.3, ENSMUST00000108175.4, ENSMUST00000108175.5, ENSMUST00000108175.6, ENSMUST00000108175.7, IKBD_MOUSE, Ikbns, NM_001360907, Q2TB02, Q3TJP0, Q8CIW1, uc291nvv.1, uc291nvv.2
UCSC ID: ENSMUST00000108175.8
RefSeq Accession: NM_001360907
Protein: Q2TB02 (aka IKBD_MOUSE)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.