ID:IKBD_MOUSE DESCRIPTION: RecName: Full=NF-kappa-B inhibitor delta; AltName: Full=I-kappa-B-delta; Short=IkB-delta; Short=IkappaBdelta; AltName: Full=IkappaBNS; FUNCTION: May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. According to PubMed:11931770, it may also regulate TCR-induced negative selection of thymocytes. SUBUNIT: Interacts with NFKB1, RELA and RELB; in the nucleus. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Specifically expressed in spleen and at low levels in thymus. Expressed in a population of antigen-presenting dendritic cells which may act as regulators of systemic inflammatory response. INDUCTION: Up-regulated in thymocytes upon TCR-triggered cell death (at protein level). Up-regulated by IL-10 or LPS. DISRUPTION PHENOTYPE: Mice are highly sensitive to LPS-induced endotoxin shock and susceptible to intestinal inflammation caused by exposure to microflora. They display no overt T-cell selection phenotype but an impaired proliferation of T-cells. Thymocytes and T-cells seem to produce less IL-2 and IFNG. SIMILARITY: Belongs to the NF-kappa-B inhibitor family. SIMILARITY: Contains 6 ANK repeats. SEQUENCE CAUTION: Sequence=BAE39455.1; Type=Frameshift; Positions=306;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q2TB02
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006954 inflammatory response GO:0032088 negative regulation of NF-kappaB transcription factor activity GO:0033085 negative regulation of T cell differentiation in thymus GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0050852 T cell receptor signaling pathway GO:0070245 positive regulation of thymocyte apoptotic process GO:2000321 positive regulation of T-helper 17 cell differentiation