Mouse Gene Grid2ip (ENSMUST00000110733.9) from GENCODE VM30
  Description: Mus musculus glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1 (Grid2ip), transcript variant 1, mRNA. (from RefSeq NM_001159321)
Gencode Transcript: ENSMUST00000110733.9
Gencode Gene: ENSMUSG00000010825.18
Transcript (Including UTRs)
   Position: mm39 chr5:143,343,093-143,377,223 Size: 34,131 Total Exon Count: 22 Strand: +
Coding Region
   Position: mm39 chr5:143,343,306-143,377,223 Size: 33,918 Coding Exon Count: 22 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2022-06-02 09:33:23

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:143,343,093-143,377,223)mRNA (may differ from genome)Protein (1203 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: GRD2I_MOUSE
DESCRIPTION: RecName: Full=Delphilin; AltName: Full=Glutamate receptor, ionotropic, delta 2-interacting protein 1;
FUNCTION: Postsynaptic scaffolding protein at the Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.
SUBUNIT: Interacts with C-terminus of the glutamate receptor GRID2 via PDZ domain. Isoform 2 interacts also with Profilin-2/PFN2 and with the monocarboxylate transporter SLC16A7 via PDZ domain. The interaction of isoform 2 with GRID2 is dependent on GRID2 phosphorylation by PKA.
SUBCELLULAR LOCATION: Isoform 2: Cell junction, synapse, postsynaptic cell membrane. Cell projection, dendritic spine. Note=Localized to the postsynaptic junction site of the parallel fiber-Purkinje cell synapse. Highly present in the dendritic spines.
SUBCELLULAR LOCATION: Isoform 3: Cell junction, synapse. Cell projection, dendritic spine. Cell membrane; Lipid-anchor (Potential). Note=Localized at the dendritic spines, but also in dendritic shafts apart fron spines.
TISSUE SPECIFICITY: Isoform 1 is expressed in the cerebellum, but not in the cerebral cortex. Isoform 2 is expressed in the cell body of purkinge cells of the cerebellum and weakly expressed in the cerebrum and the brainstem as well as various nuclei of the thalamus. Isoform 2 is highly expressed in the cerebral cortex than in the cerebellum. Isoform 3 is expressed in the cerebellum and cerebrum.
DEVELOPMENTAL STAGE: Isoform 3 expression is maintained throughout cerebellar development, while isoform 2 expression gradually decrease following the first postnatal week.
DOMAIN: PDZ 1 domain is responsible for cytoplasmic clustering of isoform 1.
PTM: Isoform 2 is palmitoylated. Palmitoylation of isoform 2 is necessary for the enhanced cell surface expression of GRID2, and is also responsible for the accumulation of isoform 2 within dendritic spines. Isoform 1 and isoform 2 are differentially localized, probably modulating GRID2 signaling in neurons.
MISCELLANEOUS: Isoform 1 shows a punctate distribution throughout the cytoplasm when expressed in COS cells, whereas isoform 2 is enriched at the edges of the plasma membranes. When expressed in cultured hippocampal neurons, isoform 1 forms clusters mainly in the dendritic shafts, whereas isoform 2 is preferentially expressed in spines.
SIMILARITY: Contains 1 FH2 (formin homology 2) domain.
SIMILARITY: Contains 2 PDZ (DHR) domains.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -61.40213-0.288 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003104 - Actin-bd_FH2/DRF_autoreg
IPR015425 - FH2_actin-bd
IPR001478 - PDZ

Pfam Domains:
PF02181 - Formin Homology 2 Domain
PF00595 - PDZ domain (Also known as DHR or GLGF)

ModBase Predicted Comparative 3D Structure on Q0QWG9
FrontTopSide
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0007216 G-protein coupled glutamate receptor signaling pathway
GO:0030036 actin cytoskeleton organization
GO:0060292 long term synaptic depression

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030054 cell junction
GO:0042995 cell projection
GO:0043197 dendritic spine
GO:0045202 synapse
GO:0045211 postsynaptic membrane


-  Descriptions from all associated GenBank mRNAs
  DQ193535 - Mus musculus L-delphilin mRNA, complete cds, alternatively spliced.
AF099933 - Mus musculus GluR-delta2 philic-protein (Delphilin) mRNA, complete cds.
BC075624 - Mus musculus glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1, mRNA (cDNA clone MGC:92989 IMAGE:6841572), complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: ENSMUST00000110733.1, ENSMUST00000110733.2, ENSMUST00000110733.3, ENSMUST00000110733.4, ENSMUST00000110733.5, ENSMUST00000110733.6, ENSMUST00000110733.7, ENSMUST00000110733.8, GRD2I_MOUSE, NM_001159321, Q0QWG9, Q6DID0, Q9ESJ5, uc009akd.1, uc009akd.2, uc009akd.3
UCSC ID: ENSMUST00000110733.9
RefSeq Accession: NM_001159321
Protein: Q0QWG9 (aka GRD2I_MOUSE)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.