Mouse Gene Tab2 (ENSMUST00000146444.7) Description and Page Index
  Description: Mus musculus TGF-beta activated kinase 1/MAP3K7 binding protein 2 (Tab2), transcript variant 1, mRNA. (from RefSeq NM_138667)
Gencode Transcript: ENSMUST00000146444.7
Gencode Gene: ENSMUSG00000015755.16
Transcript (Including UTRs)
   Position: mm10 chr10:7,905,653-7,956,230 Size: 50,578 Total Exon Count: 7 Strand: -
Coding Region
   Position: mm10 chr10:7,907,435-7,924,786 Size: 17,352 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr10:7,905,653-7,956,230)mRNA (may differ from genome)Protein (693 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; AltName: Full=Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; AltName: Full=TAK1-binding protein 2; Short=TAB-2; AltName: Full=TGF-beta-activated kinase 1-binding protein 2;
FUNCTION: Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187' (By similarity). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development (By similarity).
SUBUNIT: Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1 (By similarity).
INTERACTION: Q62073:Map3k7; NbExp=5; IntAct=EBI-1775124, EBI-1775345;
SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytosol. Note=Cytoplasmic when activated. Following IL1 stimulation, localized in the to cytosol.
TISSUE SPECIFICITY: Widely expressed.
DOMAIN: The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins.
PTM: Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to7 proteasomal degradation (By similarity).
PTM: Phosphorylated (Probable).
SIMILARITY: Contains 1 CUE domain.
SIMILARITY: Contains 1 RanBP2-type zinc finger.
SEQUENCE CAUTION: Sequence=BAC40772.1; Type=Frameshift; Positions=62, 72, 152, 275;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -269.20516-0.522 Picture PostScript Text
3' UTR -512.801782-0.288 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003892 - CUE
IPR001876 - Znf_RanBP2

Pfam Domains:
PF00641 - Zn-finger in Ran binding protein and others
PF02845 - CUE domain

SCOP Domains:
46934 - UBA-like
46966 - Spectrin repeat
90209 - Ran binding protein zinc finger-like
57903 - FYVE/PHD zinc finger

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray

ModBase Predicted Comparative 3D Structure on Q99K90
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0070530 K63-linked polyubiquitin binding

Biological Process:
GO:0007507 heart development
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045860 positive regulation of protein kinase activity

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

-  Descriptions from all associated GenBank mRNAs
  LF197910 - JP 2014500723-A/5413: Polycomb-Associated Non-Coding RNAs.
AK003993 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110030N06 product:mitogen-activated protein kinase kinase kinase 7 interacting protein 2, full insert sequence.
AB093262 - Mus musculus mRNA for mKIAA0733 protein.
LF221046 - JP 2014500723-A/28549: Polycomb-Associated Non-Coding RNAs.
LF221047 - JP 2014500723-A/28550: Polycomb-Associated Non-Coding RNAs.
AK031864 - Mus musculus adult male medulla oblongata cDNA, RIKEN full-length enriched library, clone:6330436D14 product:RIKEN cDNA 1110030N06 gene, full insert sequence.
BC004813 - Mus musculus mitogen-activated protein kinase kinase kinase 7 interacting protein 2, mRNA (cDNA clone MGC:8010 IMAGE:3586132), complete cds.
BC004072 - Mus musculus mitogen-activated protein kinase kinase kinase 7 interacting protein 2, mRNA (cDNA clone IMAGE:3591321), partial cds.
LF221048 - JP 2014500723-A/28551: Polycomb-Associated Non-Coding RNAs.
LF221049 - JP 2014500723-A/28552: Polycomb-Associated Non-Coding RNAs.
AK190119 - Mus musculus cDNA, clone:Y1G0101M14, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000015899, based on BLAT search.
AY093701 - Mus musculus TAB2 mRNA, complete cds.
LF221050 - JP 2014500723-A/28553: Polycomb-Associated Non-Coding RNAs.
AK217747 - Mus musculus cDNA, clone:Y2G0142N09, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000015899, based on BLAT search.
LF221053 - JP 2014500723-A/28556: Polycomb-Associated Non-Coding RNAs.
LF221054 - JP 2014500723-A/28557: Polycomb-Associated Non-Coding RNAs.
AK147830 - Mus musculus melanocyte cDNA, RIKEN full-length enriched library, clone:G270057H11 product:mitogen-activated protein kinase kinase kinase 7 interacting protein 2, full insert sequence.
LF221055 - JP 2014500723-A/28558: Polycomb-Associated Non-Coding RNAs.
AK089164 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630001D19 product:SIMILAR TO TAK1-BINDING PROTEIN 2, KIAA0733 PROTEIN homolog [Mus musculus], full insert sequence.
LF221062 - JP 2014500723-A/28565: Polycomb-Associated Non-Coding RNAs.
AK041067 - Mus musculus adult male aorta and vein cDNA, RIKEN full-length enriched library, clone:A530078N03 product:SIMILAR TO TAK1-BINDING PROTEIN 2, KIAA0733 PROTEIN [Mus musculus], full insert sequence.
LF221063 - JP 2014500723-A/28566: Polycomb-Associated Non-Coding RNAs.
LF221066 - JP 2014500723-A/28569: Polycomb-Associated Non-Coding RNAs.
LF221067 - JP 2014500723-A/28570: Polycomb-Associated Non-Coding RNAs.
AK201637 - Mus musculus cDNA, clone:Y1G0138N23, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000063993, based on BLAT search.
LF221068 - JP 2014500723-A/28571: Polycomb-Associated Non-Coding RNAs.
LF221069 - JP 2014500723-A/28572: Polycomb-Associated Non-Coding RNAs.
LF221071 - JP 2014500723-A/28574: Polycomb-Associated Non-Coding RNAs.
AK207065 - Mus musculus cDNA, clone:Y2G0106M23, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000063993, based on BLAT search.
AK086230 - Mus musculus 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930015C19 product:inferred: Mus musculus, Similar to TAK1-binding protein 2; KIAA0733 protein, clone MGC:8010 IMAGE:3586132, mRNA, complete cds, full insert sequence.
MA433487 - JP 2018138019-A/5413: Polycomb-Associated Non-Coding RNAs.
MA456623 - JP 2018138019-A/28549: Polycomb-Associated Non-Coding RNAs.
MA456624 - JP 2018138019-A/28550: Polycomb-Associated Non-Coding RNAs.
MA456625 - JP 2018138019-A/28551: Polycomb-Associated Non-Coding RNAs.
MA456626 - JP 2018138019-A/28552: Polycomb-Associated Non-Coding RNAs.
MA456627 - JP 2018138019-A/28553: Polycomb-Associated Non-Coding RNAs.
MA456630 - JP 2018138019-A/28556: Polycomb-Associated Non-Coding RNAs.
MA456631 - JP 2018138019-A/28557: Polycomb-Associated Non-Coding RNAs.
MA456632 - JP 2018138019-A/28558: Polycomb-Associated Non-Coding RNAs.
MA456639 - JP 2018138019-A/28565: Polycomb-Associated Non-Coding RNAs.
MA456640 - JP 2018138019-A/28566: Polycomb-Associated Non-Coding RNAs.
MA456643 - JP 2018138019-A/28569: Polycomb-Associated Non-Coding RNAs.
MA456644 - JP 2018138019-A/28570: Polycomb-Associated Non-Coding RNAs.
MA456645 - JP 2018138019-A/28571: Polycomb-Associated Non-Coding RNAs.
MA456646 - JP 2018138019-A/28572: Polycomb-Associated Non-Coding RNAs.
MA456648 - JP 2018138019-A/28574: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04010 - MAPK signaling pathway
mmu04380 - Osteoclast differentiation
mmu04620 - Toll-like receptor signaling pathway
mmu04621 - NOD-like receptor signaling pathway
mmu05140 - Leishmaniasis
mmu05145 - Toxoplasmosis
mmu05162 - Measles

Reactome (by CSHL, EBI, and GO)

Protein Q99K90 (Reactome details) participates in the following event(s):

R-NUL-1253318 ERBB4s80 binds Tab2:Ncor1 complex
R-MMU-209329 Murine MKK4 kinase is phosphorylated and activated by Phospho TAK1:Phospho TAB1:Phospho TAB2 kinase complex
R-MMU-202510 Activation of TAK1-TAB2 complex
R-NUL-1253330 ERBB4:Tab2:Ncor1 complex translocates to the nucleus
R-MMU-446870 Polyubiquitinated TRAF6 binds the TAK1 complex
R-MMU-936947 Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex
R-MMU-936960 Activated TRAF6:p-IRAK2 interacts with TAK1 complex
R-MMU-975097 Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
R-MMU-2730861 Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6
R-MMU-5357860 TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
R-MMU-5607759 TRIKA2 binds K63polyUb-TRAF6 oligomer
R-MMU-937075 Phosphorylated TAK1 leaves activated TLR receptor complex
R-MMU-936951 Activation of TAK1 complex bound to activated TLR4 complex
R-MMU-936991 Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
R-MMU-688985 K63 polyubiquitinated RIP2 associates with the TAK1 complex
R-MMU-975103 Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation
R-MMU-727819 TAK1 phosphorylates MKK6
R-MMU-5607732 K63polyUb-TAK1 autophosphorylates
R-MMU-202500 Activation of IKK complex
R-MMU-2730876 Phosphorylation of IKK-beta by TAK1
R-MMU-168184 Activated TAK1 mediates phosphorylation of the IKK Complex
R-MMU-450337 Activated TAK1 phosphorylates MKK4/MKK7
R-MMU-450346 activated human TAK1 phosphorylates MKK3/MKK6
R-MMU-5607742 K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
R-MMU-202424 Downstream TCR signaling
R-MMU-9020702 Interleukin-1 signaling
R-MMU-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-MMU-937042 IRAK2 mediated activation of TAK1 complex
R-MMU-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-MMU-2871837 FCERI mediated NF-kB activation
R-MMU-5357956 TNFR1-induced NFkappaB signaling pathway
R-MMU-5607764 CLEC7A (Dectin-1) signaling
R-MMU-202403 TCR signaling
R-MMU-168638 NOD1/2 Signaling Pathway
R-MMU-446652 Interleukin-1 family signaling
R-MMU-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-MMU-166058 MyD88:Mal cascade initiated on plasma membrane
R-MMU-975871 MyD88 cascade initiated on plasma membrane
R-MMU-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-MMU-2454202 Fc epsilon receptor (FCERI) signaling
R-MMU-75893 TNF signaling
R-MMU-5621481 C-type lectin receptors (CLRs)
R-MMU-1280218 Adaptive Immune System
R-MMU-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-MMU-449147 Signaling by Interleukins
R-MMU-166166 MyD88-independent TLR4 cascade
R-MMU-166016 Toll Like Receptor 4 (TLR4) Cascade
R-MMU-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-MMU-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-MMU-168142 Toll Like Receptor 10 (TLR10) Cascade
R-MMU-168176 Toll Like Receptor 5 (TLR5) Cascade
R-MMU-975155 MyD88 dependent cascade initiated on endosome
R-MMU-168249 Innate Immune System
R-MMU-73887 Death Receptor Signalling
R-MMU-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-MMU-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-MMU-450302 activated TAK1 mediates p38 MAPK activation
R-MMU-168256 Immune System
R-MMU-1280215 Cytokine Signaling in Immune system
R-MMU-168898 Toll-Like Receptors Cascades
R-MMU-181438 Toll Like Receptor 2 (TLR2) Cascade
R-MMU-168138 Toll Like Receptor 9 (TLR9) Cascade
R-MMU-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-MMU-162582 Signal Transduction
R-MMU-168164 Toll Like Receptor 3 (TLR3) Cascade
R-MMU-450294 MAP kinase activation
R-MMU-448424 Interleukin-17 signaling

-  Other Names for This Gene
  Alternate Gene Symbols: Kiaa0733, Map3k7ip2, NM_138667, Q3UGP1, Q8BTP4, Q8CHD3, Q99K90, Q99KP4, TAB2_MOUSE, uc007eir.1, uc007eir.2, uc007eir.3
UCSC ID: uc007eir.3
RefSeq Accession: NM_138667
Protein: Q99K90 (aka TAB2_MOUSE)
CCDS: CCDS23691.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.