Mouse Gene Mark2 (ENSMUST00000165965.7) Description and Page Index
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt E9QMP6)
Gencode Transcript: ENSMUST00000165965.7
Gencode Gene: ENSMUSG00000024969.15
Transcript (Including UTRs)
   Position: mm10 chr19:7,276,759-7,341,433 Size: 64,675 Total Exon Count: 18 Strand: -
Coding Region
   Position: mm10 chr19:7,277,090-7,341,221 Size: 64,132 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:7,276,759-7,341,433)mRNA (may differ from genome)Protein (776 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblExonPrimerGeneCardsMGIPubMedStanford SOURCE
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: E9QMP6_MOUSE
DESCRIPTION: SubName: Full=Serine/threonine-protein kinase MARK2;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -96.60212-0.456 Picture PostScript Text
3' UTR -145.90331-0.441 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001772 - Kinase-assoc_KA1
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS
IPR015940 - UBA/transl_elong_EF1B_N_euk

Pfam Domains:
PF00069 - Protein kinase domain
PF00627 - UBA/TS-N domain
PF02149 - Kinase associated domain 1
PF07714 - Protein tyrosine kinase
PF14531 - Kinase-like

SCOP Domains:
46934 - UBA-like
103243 - KA1-like
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on E9QMP6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0010976 positive regulation of neuron projection development
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0030010 establishment of cell polarity
GO:0035556 intracellular signal transduction
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0050770 regulation of axonogenesis
GO:0070507 regulation of microtubule cytoskeleton organization

Cellular Component:
GO:0005654 nucleoplasm
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016328 lateral plasma membrane
GO:0097427 microtubule bundle


-  Descriptions from all associated GenBank mRNAs
  X70764 - M.musculus mRNA for serine/threonine protein kinase.
BC058556 - Mus musculus MAP/microtubule affinity-regulating kinase 2, mRNA (cDNA clone MGC:68226 IMAGE:5289799), complete cds.
AK045329 - Mus musculus 9.5 days embryo parthenogenote cDNA, RIKEN full-length enriched library, clone:B130065L16 product:ELKL motif kinase, full insert sequence.
AK220191 - Mus musculus mRNA for mKIAA4207 protein.
AK172444 - Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830207O17 product:MAP/microtubule affinity-regulating kinase 2, full insert sequence.
AK182940 - Mus musculus cDNA, clone:Y0G0124D16, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK191836 - Mus musculus cDNA, clone:Y1G0107B20, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK178847 - Mus musculus cDNA, clone:Y0G0108B20, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK154864 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630110A02 product:MAP/microtubule affinity-regulating kinase 2, full insert sequence.
AK194221 - Mus musculus cDNA, clone:Y1G0114K14, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK218760 - Mus musculus cDNA, clone:Y2G0146D22, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK172664 - Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830226F07 product:MAP/microtubule affinity-regulating kinase 2, full insert sequence.
DQ700247 - Mus musculus piRNA piR-115569, complete sequence.
DQ727175 - Mus musculus piRNA piR-142497, complete sequence.
DQ686354 - Mus musculus piRNA piR-101676, complete sequence.
DQ713749 - Mus musculus piRNA piR-129071, complete sequence.
AK179738 - Mus musculus cDNA, clone:Y0G0111I15, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK162704 - Mus musculus adult female vagina cDNA, RIKEN full-length enriched library, clone:9930104N18 product:MAP/microtubule affinity-regulating kinase 2, full insert sequence.
AK219135 - Mus musculus cDNA, clone:Y2G0147H17, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK178494 - Mus musculus cDNA, clone:Y0G0106P13, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK180815 - Mus musculus cDNA, clone:Y0G0115P21, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK183951 - Mus musculus cDNA, clone:Y0G0128A13, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK195936 - Mus musculus cDNA, clone:Y1G0120C10, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK204296 - Mus musculus cDNA, clone:Y1G0147O09, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK213059 - Mus musculus cDNA, clone:Y2G0127A06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK215697 - Mus musculus cDNA, clone:Y2G0135O05, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK219697 - Mus musculus cDNA, clone:Y2G0149E23, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK177415 - Mus musculus cDNA, clone:Y0G0102K19, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK184786 - Mus musculus cDNA, clone:Y0G0131I04, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK211690 - Mus musculus cDNA, clone:Y2G0122I21, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK187710 - Mus musculus cDNA, clone:Y0G0142M18, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK215655 - Mus musculus cDNA, clone:Y2G0135L21, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK217185 - Mus musculus cDNA, clone:Y2G0140P16, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK210480 - Mus musculus cDNA, clone:Y2G0118J03, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.
AK218887 - Mus musculus cDNA, clone:Y2G0146K13, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000025921, based on BLAT search.

-  Other Names for This Gene
  Alternate Gene Symbols: AK045329, E9PWB5, E9QMP6, E9QMP6_MOUSE, uc008gkr.1, uc008gkr.2, uc008gkr.3
UCSC ID: uc008gkr.3
RefSeq Accession: NM_007928
Protein: E9QMP6 CCDS: CCDS37904.1, CCDS37905.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.